目的:评价奈达铂联合氟脲嘧啶/四氢叶酸治疗晚期复发耐药食管癌的疗效及不良反应。方法:30例晚期复发耐药食管癌均经病理学或细胞学确诊。奈达铂100mg/㎡,静脉滴注,第1天;氟脲嘧啶500mg/㎡,静脉滴注,维持6～8小时,第1～5天; 四氢叶酸200mg,静脉滴注,第1～5天,21天为一周期,连续用2周期后评价疗效及不良反应。结果:30例均完成2个周期以上化疗,共接受86周期化疗,全部病例均可评价疗效及不良反应。无CR病例,PR 13例(43.3%),SD 7例(23.3%),PD 10例(33.3%),有效率为43.3%,TTP 4.0月,MST8.3月。不良反应主要是骨髓抑制,恶心、呕吐,全组无IV度不良反应。结论:奈达铂联合氟脲嘧啶/四氢叶酸治疗晚期复发耐药食管癌有确切疗效,不良反应轻,耐受性好,值得临床进一步推广应用。
Citation：
YIN Xude,CHEN Ping,LU Jin,et al.. Clinical Study of Nedaplatin plus 5Fluorouracil/Folinic Acid for the Treatment of Advanced Esophageal Cancer. West China Medical Journal, 2009, 24(6): 1408-1409. doi:
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- 1. YAMANAKA H,MOTOHIRO T,MICHIURA T, et al.Nedaplatin and 5FU combined with radiation in the treatment for esophageal cancer[J].Jpn J Thorac Cardiovasc Surg,1998,46(10):943-948.
- 2. NEMOT K, MATSUSHITA H, OGAWA Y.Radiation therapy combined with cisdiammineglycolatoplatinum(Nedaplatin) and 5fluorouracil for untreated and recurrent esophageal cancer[J]. Am J Clin Oncol,2003,26(1):46-49.
- 3. HIRATA S,YATSUYANAGI E,YAMAZAKI H, et al.Neoadjuvant chemotherapy for esophageal cancer by administration of nedaplatin alone[J].Gan To Kagaku Ryoho,2000,27 (2):221226.
- 4. YOSHIOKA T,GAMOH M,SHINEHA R, et al.A new combination chemotherapy with cisdiammineglycolatoplatinum (Nedaplatin) and 5fluorouracil for advanced esophageal cancers[J]. Intern Med,1999,38 (11):844-848.
- 5. TAGUCHI T,WAKUI A,NABEYA K, et al.A phase Ⅱ clinical study of cisdiammine glycolatoplatinun,254S,for gastrointestinal cancers.254S Gastrointestinal Cancer Study Group[J].Gan To Kagaku Ryoho,1992,19(4):483-488.
