Langerhans Cell Histiocytosis of the Thyroid: A Report of 2 Cases_West China Medical Journal

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Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China;

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Keywords：

郎罕氏细胞; 组织细胞增多症; 甲状腺肿大; 化疗

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目的:探讨郎罕氏组织细胞增多症累及甲状腺的临床表现,诊治及预后。方法: 淋巴结病理活检及免疫组化证实郎罕氏组织细胞增多症的诊断,颈部血管彩超发现甲状腺长大。予以小剂量化疗。结果: 2例患者均为系统性郎罕氏组织细胞增多症,累及甲状腺,予以小剂量化疗后,其中1例患者,化疗后淋巴结及甲状腺明显缩小。另1例患者广泛受累,化疗后效果差。结论: 郎罕氏组织细胞增多症累及甲状腺者罕见,可表现为甲状腺单独受累或伴多系统受累,对前者可采用甲状腺部分或全切术,疗效好;对于多器官受累者多采用联合化疗,但疗效较差。

Citation： DAI Yang,CHEN Xinchuan,HUANG Xiaoou,et al.. Langerhans Cell Histiocytosis of the Thyroid: A Report of 2 Cases. West China Medical Journal, 2009, 24(6): 1543-1545. doi: Copy

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1. HAND J. Jr polyuria and tuberculosis[J]. Arch Pediatr, 1893,10:673.
2. BEGüL YACI, NURGüN KANDEMIR, NALAN YAZICI, et al. Thyroid involvement in Langerhans cell histiocytosis: a report of two cases and review of the literature [J].Eur J Pediatr,2007, 166: 901-904.
3. YUANCHIEH YEH,JENGCHANG CHEN, CHIASUI HUNG,et al. Isolated Langerhans cell histiocytosis of the thyroid in a female infant[J]. Eur J Pediatr,2007, 166:1151–1153.
4. ZHU H, HU DX. Langerhans cell histiocytosis of the thyroid diagnosis by fine needle aspiration cytology.A case report[J]. Cytol, 2004,48:278-280.
5. FOULETROG A, JOSSELIN N, GUYETANT S, et al. Incidental langerhans cell histiocytosis of thyroid: case report and review of the literature[J]. Endocr Pathol, 2002,13:227-233.
6. TITGEMEYER C, GROIS N, MINKOV M, et al, Pattern and course of singlesystem disease in Langerhans cell histiocytosis data from the DAL-HX 83- and 90-study[J]. Med Pediatr Oncol,2001,37:108114.
7. ROBERT J.BEHRENS, ANGELIQUE W.LEVEL, WILLIAM H.WESTRA. Langerhans cell histiocytosis of the thyroid: A report of two cases and review of the literature[J]. Thyroid, 2001,11:697-705.

West China Medical Journal

Langerhans Cell Histiocytosis of the Thyroid: A Report of 2 Cases

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