Clinical Significance of Fibrinolysis and Fibrinogen in Unstable Angina Pactoris Patients_West China Medical Journal

Authors：

LIANG Zhenlian ¹ , MA Jianlin. ²

1Department of Emergency,the People`s Hosptal OF Wenchang City, Wenchang Hainan 571300, china;2Department of Cardiovascular Disease, Hainan Provincial People`s Hospital, Haikou Hainan 570311, China;

Corresponding author：

Keywords：

纤溶系统:纤维蛋白原:不稳定型心绞痛; 心血管事件

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目的:探讨并研究纤溶系统与纤维蛋白原在不稳定型心绞痛(UA)患者发病中的临床价值。方法:对108例不稳定型心绞痛患者和42稳定型心绞痛(SA)患者体内纤溶酶原激活物抑制剂-1(PAI-1)、组织型纤溶酶原激活剂(t-PA)、纤维蛋白原(FIB)水平进行检测,并与20例正常对照者进行对照,探讨其临床意义。结果:UA患者体内PAI-1、FIB水平明显高于SA患者和正常对照者,UA患者中有心血管事件发生者也明显高于无心血管事件发生者;UA患者体内t-PA水平明显低于SA患者和正常对照者,UA患者中有心血管事件发生者也明显低于无心血管事件发生者。结论:UA 患者纤溶系统功能异常和FIB水平升高程度较SA患者更加明显,并且UA患者的心血管事件发生可能与溶系统功能异常和FIB水平升高相关。

Citation： LIANG Zhenlian,MA Jianlin.. Clinical Significance of Fibrinolysis and Fibrinogen in Unstable Angina Pactoris Patients. West China Medical Journal, 2009, 24(7): 1719-1721. doi: Copy

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1. LIBBY P. Current concepts of the pathogenesis of the acute coronary syndrome[J]. Circulation, 2001,104(3):365-372.
2. YAZICI M, DEMIRCAN S, DURNA K,et al. Relationship Between Myocardial Injury and Soluble PSelectin in NonST Elevation Acute Coronary Syndromes[J].Circulation Journal, 2005,69(5):1346-1350.
3. TARNOK A. Diurnal Variation of Soluble E-and P-Selectin, and Intercellular Adhesion Molecule-1 in Patients with and without Coronary Artery Disease[J]. Cardiology,2004,102(4):6308-6312.
4. TUSS H, LINDAHL B, SIEGBAHN A, et al.Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease[J].Eur Heart J, 1998,19(Suppl H):H11-17.
5. GRUNDT H, NILSEN DW, HETLAND O, et al. Activated factor 12 (FXIIa) predicts recurrent coronary events after an acute myocardial infarction[J]. Am Heart J, 2004,147 (2):8702-8708.
6. DECALF V, SABBAH L, LAFONT A, et al. GpⅡb/Ⅲa receptor antagonists in acute coronary syndromes with no ST elevention[J]. Arch Mal Coeur Vaiss, 2007,100(12):1006-1012.
7. 马建林,王圣,李新明,等.冠心病患者D二聚体、血小板膜糖蛋白测定及意义.中华心血管并杂志,2005,33(8):724-726.
8. KEATING F K, WHITAKER D A, SOBEL B E,et al. Augmentation of inhibitory effects of glycoprotein IIbIIIa antagonists in patients with diabetes[J]. Thrombosis Research, 2004,113 (1):3848-3853.
9. ORGAZ S, CARRASCO C, BURGOS M E, et al. Proteomic analysis of plasma from patients during an acute coronary syndrome[J]. J Am Coll Cardio, 2004,44(8) 1091-1097.
10. DEVARAJ S, XU D Y, JIALAL I. Creactive protein increase plasminogen activator inhibitor 1 expression and activity in human aortic endothelial cell:implication for the metabolic syndrome and atherothrombosis[J]. Circulation,2003,107(3):398-404.
11. CHNG T L, PUMPLIN D W, HOLLTON L H, et al. Prevention of microsurgical anastomotic thrombosis using aspirin,heparin,and the glycoprotein Ⅱb/Ⅲa inhibitor tirofiban[J]. Plast Reconstr Surg, 2007,120(5):1281-1288.
12. TOSS H, LINDAHL B, SIEGHAHN A, et al. Prognostic influence of increased fibringen and Creactive protein levels in unstable coronary artery disease[J]. Circulation,1997,96(12):4204-4210.

West China Medical Journal

Clinical Significance of Fibrinolysis and Fibrinogen in Unstable Angina Pactoris Patients

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