The Effect of Rosiglitazone on Insulin Sensitivity and Inflammatory Factors in Type 2 Diabetic Patients_West China Medical Journal

Authors：

ZHANG Huazhen ¹ , YANG Jiao ² , SU Yanhui ² , et al. ²

1 People’s Hospital of Luzhou City; 2 Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou Sichuan 646000, China;

Corresponding author：

Keywords：

胰岛素抵抗; 炎症介质; 罗格列酮; 2型糖尿病

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目的:研究罗格列酮(ROS)治疗2型糖尿病,对患者组织胰岛素敏感性与血清炎症介质改变的关系。方法:选取符合1999年WHO标准确诊的2型糖尿病患者30例。试验采用前后自身配对方法。口服ROS 4mg每天一次,总疗程8周。测定指标包括常规临床检查项目、血糖,同时检测血浆胰岛素水平,糖化血红蛋白(HbA1c)水平、C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,以 HOMA模型和胰岛素钳夹试验评价组织胰岛素敏感性。结果:应用ROS治疗的2型糖尿病患者组织胰岛素敏感性显著改善(P lt;0.05),并降低血浆CRP、IL-6、TNF-α水平,这些炎症介质的改变与组织胰岛素敏感性的改变相关。结论:应用ROS治疗2型糖尿病能降低患者血浆炎症介质水平,减轻胰岛素抵抗,延缓或减轻糖尿病大血管并发症的发生发展。

Citation： ZHANG Huazhen,YANG Jiao,SU Yanhui,et al.. The Effect of Rosiglitazone on Insulin Sensitivity and Inflammatory Factors in Type 2 Diabetic Patients. West China Medical Journal, 2009, 24(7): 1730-1732. doi: Copy

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5.	朱禧星,潘长玉,李光伟,等.磺酰脲类药物合用马来酸罗格列酮治疗2型糖尿病的有效性和完全性观察[J].中华内分泌代谢杂志,2003,19:31-36.
6.	FAHIM A, NEREIDA KCL, GERALD M R. Relationship between changes in insulin sensitivity and associated cardiovascular disease risk factors in thiazolidinedionetreated,insulinresistant, nondiabetic individuals:pioglitazone versus rosiglitazone[J]. Metabolism Clinical and Experimental,2009,(58):373-378.

1. DEFRONZO R A, TOBIN J D, ANDRES R. Glucose clamp technique:a method for quantifying insulin secretion and resistance[J].Am J Physiol,1979,237:E214-E223.
2. LYON C J, LAW R E, HSUEH W A. Minireview:adiposity,inflanmmation,and therogenesis[J].Endocrinology,2003,144(6):2195-2200.
3. IACOPION. A M. Periodontitis and diabetes interrelationships:role in flammation [J].Ann Periodontol,2001,6(1):125-137.
4. MEI J, WANG C N, O BRIEN L, et al. Cellpremeable ceramides in basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes[J]. Int J.Obes Relat Metab Disord,2003,27(1):31-39.
5. 朱禧星,潘长玉,李光伟,等.磺酰脲类药物合用马来酸罗格列酮治疗2型糖尿病的有效性和完全性观察[J].中华内分泌代谢杂志,2003,19:31-36.
6. FAHIM A, NEREIDA KCL, GERALD M R. Relationship between changes in insulin sensitivity and associated cardiovascular disease risk factors in thiazolidinedionetreated,insulinresistant, nondiabetic individuals:pioglitazone versus rosiglitazone[J]. Metabolism Clinical and Experimental,2009,(58):373-378.

West China Medical Journal

The Effect of Rosiglitazone on Insulin Sensitivity and Inflammatory Factors in Type 2 Diabetic Patients

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