Clinical Observation on Suxuetong Injection with ACEI/ARB for Early Diabetic Nephropathy_West China Medical Journal

Authors：

1 The Second Hospital of Liangshan,Xichang Sichuan 615000;2Department of nephrology,West China Hospital,Sichuan University,Chengdu 610041, China;

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Keywords：

疏血通注射液; 早期糖尿病肾病

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目的:观察采用疏血通注射液联合ACEI/ARB治疗早期糖尿病肾病(DN)的疗效。方法:将78例2型DN患者随机分为对照组(ACEI/ARB)和治疗组(ACEI/ARB+疏血通注射液),疗程4周。比较两组治疗前和治疗后尿微量白蛋白(mAlb),Scr、BUN等指标的变化。结果:(1)治疗后治疗组和对照组尿白蛋白均显著下降(P lt;0.01,P lt;0.05),治疗组比对照组下降更为明显(P lt;0.05)。(2)治疗后两组血浆白蛋白均增加(P lt;0.01),治疗组与对照组治疗后比较无明显差异(P gt;0.05)。(3)治疗后两组Scr、BUN、TC、TG和血钾均无明显变化。结论:联合应用疏血通注射液能有效减少早期DN患者的蛋白尿,改善肾功能。

Citation： DAI Pin,CAI Wenjing,LIAO Yanli,et al. Clinical Observation on Suxuetong Injection with ACEI/ARB for Early Diabetic Nephropathy. West China Medical Journal, 2009, 24(7): 1748-1750. doi: Copy

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12.	ASAKAWA H, TOKUNAGA K, KAWAKAMI F. Elevation of fibrinogen and thrombinantithrombin III complex levels of type 2 diabetes mellitus patients with retinopathy and nephropathy[J]. Diabetes Complications,2000,14(3):121-6.
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2. ZUO L,WANG M;Beijing Hemodialysis Quality Control and Improvement Center.Current status of hemodialysis treatment in Beijing, China[J].Ethn Dis,2006,16(2 Suppl 2):S2-31-4.
3. K/DOQI clinical practice guidelines on hypertension and antihypertensive agents in chronic kidney disease.National Kidney Foundation- Disease Specific Society.2004 May. 290 pages.NGC:003985.
4. American Diabetes Association. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus[J].Diabetes Care,1997,20:1183.
5. WITTMANN I,DEGRELL P,KOMAROMY A, et al.The role of angiotensin Ⅱ Atireceptor antagonists in renal and cardiac protection in type2 diabetesmellitus[J].Ital Heart J Suppl,2003,4(3):210-216.
6. PARVING HH,ANDERSEN S,JACOBSEN P, et al.Angiotensin receptor blockers in diabetic nephropathy:real and cardiovascular end points[J].Semin Nephrol,2004,24(2):147-157.
7. RODONDI N,YERLY P,GABRIEL A, et al.Microalbuminuria,but not cystatin C,is associated with carotid atherosclerosis in middleaged adults[J].Nephrol Dial Transplant, 2007,22(4):1107-14.
8. WADA M, NAGASAWA H, KURITA K, et al.Microalbuminuria is a risk factor for cerebral small vessel disease in communitybased elderly subjects[J]. J Neurol Sci, 2007,255(1-2):27-34.
9. STRIPPOLI GF, DI PAOLO S, CINCIONE R, et al. Clinical and therapeutic aspects of diabetic nephropathy[J]. J Nephrol,2003,16:487-499.
10. NOSADINI R, VELUSSI M, BROCCO E, et al. Course of renal function in type 2 diabetic patients with abnormalities of albumin excretion rate[J]. Diabetes, 2000,49:476-484.
11. SUN X, ZHOU X, YAN H. Hypercoagulation aggravates renal dysfunction in patient with diabetic nephropathy[J]. Zhonghua Xue Ye Xue Za Zhi, 2001,22(9):476-7.
12. ASAKAWA H, TOKUNAGA K, KAWAKAMI F. Elevation of fibrinogen and thrombinantithrombin III complex levels of type 2 diabetes mellitus patients with retinopathy and nephropathy[J]. Diabetes Complications,2000,14(3):121-6.
13. 陈华友,黄静,蒋芝君,等.抗凝良药水蛭素的研究进展[J].生物学通报,2003,38(3):3.
14. 刘捷,张秀杰,李辉.疏血通治疗脑梗塞疗效观察[J].中华中西医结合杂志,2001,22(2):31-32.
15. VIBERTI G,WHEELDON NM.Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus[J].Circulation,2002,106(6):672.

West China Medical Journal

Clinical Observation on Suxuetong Injection with ACEI/ARB for Early Diabetic Nephropathy

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