Analysis of the Relationship between the Valence of IgG Antibody In Pregnant Women with Blood Type O and the Rate of Hemolytic Disease in the Newborn_West China Medical Journal

Authors：

JIANG Jun , XU Ying.

Department of blood transfusion, First affiliated hospital of Chengdu Medical College, Chengdu 610500, China;

Corresponding author：

Keywords：

微柱凝胶免疫检测法; 效价; 新生儿溶血病; 血型鉴定

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目的:研究O型RhD阳性孕妇(其丈夫为非O型)血清IgG抗-A(抗-B)抗体效价与新生儿溶血病(HDN)的关系。方法:应用微柱凝胶技术对382例O型RhD阳性孕妇进行了免疫性IgG抗A(B)抗体效价检测及对其新生儿进行HDN(①新生儿ABO、Rh系统定型;②新生儿直抗实验;③游离IgG测定;④放散实验)的检测。结果:382例O型RhD阳性孕妇中IgG抗-A(B)效价 lt;64者330例(占总数86.39%),抗体效价≥64者13.61%。其中发生HDN 5例,抗-A 3例,抗-B12例,总发生率1.31%.结论:夫妇血型不合应及时检测孕妇IgG抗体,随着孕妇体内IgG抗体效价的增高,新生儿ABO溶血病的发病率也随之升高。孕妇产前应定时进行IgG抗体检测,了解效价与新生儿溶血病发病率之问的关系,对于预防新生儿溶血病极为有效。

Citation： JIANG Jun,XU Ying.. Analysis of the Relationship between the Valence of IgG Antibody In Pregnant Women with Blood Type O and the Rate of Hemolytic Disease in the Newborn. West China Medical Journal, 2009, 24(7): 1761-1763. doi: Copy

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West China Medical Journal

Analysis of the Relationship between the Valence of IgG Antibody In Pregnant Women with Blood Type O and the Rate of Hemolytic Disease in the Newborn

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