Effect of Valsartan on Reverse Left Ventricular Hypertrophy in Patients with Mildmoderate Essential Hypertension_West China Medical Journal

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The Third People’s Hospital of Chengdu City, Chengdu 610031, China;

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Keywords：

缬沙坦; 原发性高血压; 左心室肥厚

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目的:观察缬沙坦逆转轻中度原发性高血压左室肥厚的疗效。方法:采用自身对照试验, 116 例轻中度原发性高血压伴左室肥厚的患者, 服用缬沙坦80～160mg/d, 共36 周, 随访患者血压、超声心动图及不良反应。结果: 116例患者治疗后血压明显下降(P lt;0.05), 左心室舒末内径(LVDd)、室间隔厚度(IVST) 、心室后壁厚度(PWT) 、左室重指数(LVMI) 均明显减少 (P 均 lt;0.01),无明显不良反应。结论: 缬沙坦治疗轻中度原发性高血压疗效确切, 有效逆转左室肥厚。

Citation： WU Jing,CAI Lin,WANG Wei,et al.. Effect of Valsartan on Reverse Left Ventricular Hypertrophy in Patients with Mildmoderate Essential Hypertension. West China Medical Journal, 2009, 24(7): 1818-1820. doi: Copy

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13.	NIPPON RINSHO.2009,67(4):723-8..
14.	陈文彬,罗德成,主编. 临床药物治疗学[M]. 北京:人民卫生出版社,2004:107..
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1.
2. 英俊岐, 王歆月, 濮蓉晖, 等. 高血压左室肥厚形成及其逆转研究进展[J]. 医学综述, 2003, 9 (12): 738-740..
3. 许智韬, 王玮, 田青, 等. 高血压患者左心室肥厚与QT离散度增大[J]. 中华心律失常杂志, 2000, 4: 276-277..
4. LEENEN FHH. Left ventricular hypertrophy in patients [J]. Am J Med, 1989, 86 (IB): 63-67..
5. 刘力生. 中国高血压防治指南[M]. 北京: 人民卫生出版社,2005: 14..
6. CIRCULATION. 2009,119(4):524-9..
7. MED PREGL.2008,61(7-8):369-374..
8. 丁国峰, 孙运爱, 武金莲, 等. 氨氯地平治疗高血压及逆转左室肥厚作用的临床研究[J]. 心血管康复医学杂志, 2004, 13(2): 163-165..
9. BRAZ NOGUEIRA J. Regression of left ventricular hypertrophy in hypertensiondoes it reduce cardiovascular risk? [J]. Rev Port Cardiol, 2005, 24 (728): 1007-1013..
10. OKIN PM, DEVEREUX RB, JERN S, et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatmentand the prediction of major cardiovascular events[ J ]. JAMA, 2004,292 (19): 2343-2349.
11. CONRADY AO, RUDOMANOV OG, ZAHAROV DV, et al. Prospective study of the changes in left ventricularmass and geometry patterns in hypertensive patients During 5 years of followup [ J ]. Circ J, 2005, 69(11): 1374-1379..
12. DEVEREUX RB. Therapeutic options in minimizing left ventricular hypertrophy [ J ]. Am Heart J, 2000,139: 9..
13. NIPPON RINSHO.2009,67(4):723-8..
14. 陈文彬,罗德成,主编. 临床药物治疗学[M]. 北京:人民卫生出版社,2004:107..
15. CALIFF RM, COHN JN, MINM M. Cardiac protection: Evolving role of angiotensin receptor blockers [ J ]. Am Heart J, 2000, 139: 15..

West China Medical Journal

Effect of Valsartan on Reverse Left Ventricular Hypertrophy in Patients with Mildmoderate Essential Hypertension

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