Effects of Amlodipine Tablets (Norwasc) on the DayNight Rhythm of Blood Pressure and Ambulatory Arterial Stiffness Index in the Elderly with Essential Hypertension_West China Medical Journal

Authors：

HE Haoting

Department of Cardiovascular Diseases, Guangzhou Traditional Chinese Medicine Hospital, Guangzhou 510130, China;

Corresponding author：

Keywords：

老年; 高血压; 血压昼夜节律; 动态动脉硬化指数; 氨氯地平

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目的:观察氨氯地平片治疗非杓型老年高血压患者对血压昼夜节律异常及对动态动脉硬化指数(AASI)的影响。方法:80例患者每日晨8时顿服氨氯地平5～10mg/d,服药前及治疗8周后行24h动态血压监测。结果:80例完成治疗的患者中,60例血压昼夜节律异常逆转,同时改善AASI。而20例血压昼夜节律无逆转,AASI与治疗前比较无差异。结论:经氨氯地平片治疗后,75%的非杓型高血压患者,可改善血压昼夜节律异常及AASI。

Citation： HE Haoting. Effects of Amlodipine Tablets (Norwasc) on the DayNight Rhythm of Blood Pressure and Ambulatory Arterial Stiffness Index in the Elderly with Essential Hypertension. West China Medical Journal, 2009, 24(7): 1844-1846. doi: Copy

1.	MAURIZIO G, ANTONIO P, ALFONSO A, et al . Impact of ambulatory blood pressure on left ventricular diastolic dysfuncfion in uncomplicated arterial systemic hypertension[J]. Am J Cardio,1996,77 (8):597-99..
2.	LI Y, DOLAN E, WANG J G, et al . Ambulatory arterial stiffness index:determinant s and outcome[J]. Blood Press Monit,2006,11(2):107-10..
3.	LI Y, WANG J G, DOLAN E, et al. Ambulatory arterial stiffness index derived from 24hour ambulatory blood pressure monitoring[J]. Hypertension, 2006,47(5): 359-64..
4.	LEONCINI G, RATTO E, VIAZZI F,et al.Increased ambulatory arterial stiffness index is associated with target organ damage in primary hypertension[J].Hypertension,2006,48(3):397-03..
5.	韩全乐,高竞生,郝冰.动态血压监测及其临床应用新进展[J].中国煤炭工业医学杂志,2008,11(1):125127..
6.	O’BRIEN,SHERIDAN J, O’MALLET K. Dipper and non dipper [J ]. The Lancet,1988,11(8):397..
7.	龚兰生,刘力生. 血压昼夜变异及其临床意义[J]. 中华心血管病杂志,1994,22(5):323-25..
8.	刘宝林,孟超,方宁远．老年高血压患者血压昼夜节律与左心室肥厚的相关性[J]．上海交通大学学报(医学版),2008,28(5):509-11..
9.	刘卫,刘建国,苏定冯. 评价抗高血压药的新观点和新方法[J].中国药学杂志,1999,15(3):147..
10.	YAN L I, JIGUANG WANG, EAMON D, et al. Ambulatory Arterial Stiffness Index Derived from 24Hour Ambulatory Blood Pressure Monitoring[J].Hypertension, 2006, 47(3):359-64..
11.	MACWILLIAM J A, MELVIN G S. Systolic and Diastolic Blood Pressure Estimation, with Special Reference to the Auditory Methods [J].BMJ, 1914, 2: 693-97..
12.	DOLAN E, THIJS L, LI Y, et al. Ambulatory aterial stiffness index as a predictor of cardiovascular mortality in the Dublin outcome study[J]. Hypertension,2006,47(2):365-70..
13.	张雪娟,徐传金,唐晓燕,等.动态血压监测评价苯磺酸氨氯地平和氯沙坦对老年单纯收缩期高血压的降压疗效[J].中国医院药学杂志,2008,28(3):137-39..
14.	李明珠,杜萱.动态动脉硬化指数与动脉硬化研究进展[J].中华老年心脑血管病杂志,2008,17(10):952-54..

1. MAURIZIO G, ANTONIO P, ALFONSO A, et al . Impact of ambulatory blood pressure on left ventricular diastolic dysfuncfion in uncomplicated arterial systemic hypertension[J]. Am J Cardio,1996,77 (8):597-99..
2. LI Y, DOLAN E, WANG J G, et al . Ambulatory arterial stiffness index:determinant s and outcome[J]. Blood Press Monit,2006,11(2):107-10..
3. LI Y, WANG J G, DOLAN E, et al. Ambulatory arterial stiffness index derived from 24hour ambulatory blood pressure monitoring[J]. Hypertension, 2006,47(5): 359-64..
4. LEONCINI G, RATTO E, VIAZZI F,et al.Increased ambulatory arterial stiffness index is associated with target organ damage in primary hypertension[J].Hypertension,2006,48(3):397-03..
5. 韩全乐,高竞生,郝冰.动态血压监测及其临床应用新进展[J].中国煤炭工业医学杂志,2008,11(1):125127..
6. O’BRIEN,SHERIDAN J, O’MALLET K. Dipper and non dipper [J ]. The Lancet,1988,11(8):397..
7. 龚兰生,刘力生. 血压昼夜变异及其临床意义[J]. 中华心血管病杂志,1994,22(5):323-25..
8. 刘宝林,孟超,方宁远．老年高血压患者血压昼夜节律与左心室肥厚的相关性[J]．上海交通大学学报(医学版),2008,28(5):509-11..
9. 刘卫,刘建国,苏定冯. 评价抗高血压药的新观点和新方法[J].中国药学杂志,1999,15(3):147..
10. YAN L I, JIGUANG WANG, EAMON D, et al. Ambulatory Arterial Stiffness Index Derived from 24Hour Ambulatory Blood Pressure Monitoring[J].Hypertension, 2006, 47(3):359-64..
11. MACWILLIAM J A, MELVIN G S. Systolic and Diastolic Blood Pressure Estimation, with Special Reference to the Auditory Methods [J].BMJ, 1914, 2: 693-97..
12. DOLAN E, THIJS L, LI Y, et al. Ambulatory aterial stiffness index as a predictor of cardiovascular mortality in the Dublin outcome study[J]. Hypertension,2006,47(2):365-70..
13. 张雪娟,徐传金,唐晓燕,等.动态血压监测评价苯磺酸氨氯地平和氯沙坦对老年单纯收缩期高血压的降压疗效[J].中国医院药学杂志,2008,28(3):137-39..
14. 李明珠,杜萱.动态动脉硬化指数与动脉硬化研究进展[J].中华老年心脑血管病杂志,2008,17(10):952-54..

West China Medical Journal

Effects of Amlodipine Tablets (Norwasc) on the DayNight Rhythm of Blood Pressure and Ambulatory Arterial Stiffness Index in the Elderly with Essential Hypertension

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