目的:探讨莫西沙星注射液应用在中重度急性腹腔感染治疗中的临床疗效与安全性。方法:共纳入31 例患者,随机分为罗氏芬加甲硝唑治疗组(对照),罗氏芬2 g,每日1次,甲硝唑0.5 g,每日2次;莫西沙星治疗组,莫西沙星400mg,每日1次,均为静脉滴注,疗程为7~14 天。结果:两组的痊愈率分别为80 %和81.25 %,有效率分别为86.67 %和87.5 %,细菌清除率分别为91.67%与90%。组间比较差异均无统计学意义。两组的不良反应发生分别为2/15和 1/16,主要表现为局部刺激及转氨酶升高等。结论:莫西沙星注射液治疗中重度腹腔细菌感染疗效确切,安全性好。
Citation:
LI Xuemei,HUANG Liping.. Clinical Application of Moxifloxacin in the Treatment of Intraabdominal Bacterial Infections. West China Medical Journal, 2009, 24(7): 1856-1858. doi:
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MIRAVITLLES M, ANZUETO A. Moxifloxacin: a respiratory fluoroquinolone [J]. Expert Opin Pharmacother, 2008, 9(10):1755-1772.
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SIMOENS S, DECRAMER M. A pharmacoeconomic review of the management of respiratory tract infections with moxifloxacin [J]. Expert Opin Pharmacother, 2008, 9(10):1735-1744.
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RINK AD, STASS H, DELESEN H, KUBITZA D, VESTWEBER KH. Pharmacokinetics and tissue penetration of moxifloxacin in intervention therapy for intraabdominal abscess [J]. Clin Drug Investig, 2008, 28(2):71-79.
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- 1. MIRAVITLLES M, ANZUETO A. Moxifloxacin: a respiratory fluoroquinolone [J]. Expert Opin Pharmacother, 2008, 9(10):1755-1772.
- 2. SIMOENS S, DECRAMER M. A pharmacoeconomic review of the management of respiratory tract infections with moxifloxacin [J]. Expert Opin Pharmacother, 2008, 9(10):1735-1744.
- 3. RINK AD, STASS H, DELESEN H, KUBITZA D, VESTWEBER KH. Pharmacokinetics and tissue penetration of moxifloxacin in intervention therapy for intraabdominal abscess [J]. Clin Drug Investig, 2008, 28(2):71-79.