Prognostic Value of C-Reactive Protein Levels on the Patients with Acute Myocardial Infarction_West China Medical Journal

Authors：

YIN Libo ¹ , WANG Chunmei ²

1 Department of Cardiology, the Red Cross Hospital of Leshan, Leshan Sichuan 614000, China;

Corresponding author：

Keywords：

C-反应蛋白; 测定急性心肌梗死; 心功能; 病死率

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目的:观察血清C-反应蛋白(CRP) 水平与急性心肌梗死(AMI)患者6个月时心功能及病死率的关系。方法:入选我院572例AMI住院患者,根据入院时CRP水平分为CRP升高组及CRP正常组,随访6个月,记录超声心动图结果及死亡例数。结果:两组基线资料无明显差异。与入院时CRP正常组比较,CRP升高组患者6个月时LVEDD、LVESD,住院期间及随访期间病死率显著增加,而6个月时LVEF显著降低 (P lt; 0.05)。多因素分析结果显示入院时CRP升高是AMI患者住院期间及6个月病死率的独立危险因素。结论:血清CRP升高是AMI患者心功能及病死率的预测因素,关注AMI患者血清CRP水平,尽早开始控制,有利于改善AMI的预后。

Citation： YIN Libo,WANG Chunmei. Prognostic Value of C-Reactive Protein Levels on the Patients with Acute Myocardial Infarction. West China Medical Journal, 2009, 24(8): 2003-2005. doi: Copy

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5.	LIBBY P, RIDKER P M, MASERI A. Inflammation and atherosclerosis[J]. Circulation, 2002,105: 1135.
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7.	MUELLER C, BUETTNER H J, HODGSON J M. Inflammation and Longterm mortality after nonSTelevation acute coronary syndrome treated with a very early invasive strategy in 1 042 consecutive patients[J].Circulation,2002,105:1412.
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1. RIDKER P M. Highsensitivity Creactive protein: potential adjunct for global risk assessmention the primary prevention of cardiovascular disease[J].Circulation, 2001, 103: 1813-1818.
2. RIDKER P M, RIFAI N, STAMPFER M J, et al. Plasma concentration of interleukin6 and the risk of future myocardial infarction among apparently healthymen[J]. Circulation, 2000, 101: 1767-1772.
3. PEARSON T A, MENSAH G, ALEXANDER R W,et al. Markers of inflammation and cardiovascular disease;Application to clinical and public health practice: a statement for health care professionals from the Centers for Disease Control and Prevention and the American Heart Association[J]. Circulation, 2003,107:499.
4. RIDKER P M, STAMPFER M J, RIFAI N. Novel risk factors for systemic atherosclerosis: a comparison of Creactive protein fibrinogen, homocysteine, lipoprotein(a) and standard cholesterol screening as predictors of peripheral arterial disease[J].JAMA, 2001,285:2481.
5. LIBBY P, RIDKER P M, MASERI A. Inflammation and atherosclerosis[J]. Circulation, 2002,105: 1135.
6. SAKKINEN P, ABBOTT R D, CURB J D, et al. Creactive protein and myocardial infarction[ J ]. J Clin Epidemiol, 2002, 55 (5): 445-451.
7. MUELLER C, BUETTNER H J, HODGSON J M. Inflammation and Longterm mortality after nonSTelevation acute coronary syndrome treated with a very early invasive strategy in 1 042 consecutive patients[J].Circulation,2002,105:1412.
8. ALMAGOR M, KEREN A, BANAI S. Increased C reactive protein level after coronary stent implantation in patients with stable coronary artery disease[J].Am Heart J,2003,145(2):248.

West China Medical Journal

Prognostic Value of C-Reactive Protein Levels on the Patients with Acute Myocardial Infarction

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