Expression of Monocyte Chemoattractant Protein4 in Rheumatoid Arthritis and its Clinical Significance_West China Medical Journal

Authors：

1.the Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041; 2.the Department of Rheumatology and Immunology, The Center Hospital of Mianyang City, Mianyang Sichuan 621000, China;

Corresponding author：

Keywords：

单核细胞趋化蛋白4; 关节炎; 类风湿

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目的:研究CC亚族趋化因子单核细胞趋化蛋白-4(MCP-4/CCL13)在类风湿关节炎(RA)患者外周血的表达水平,并分析MCP-4的水平与疾病活动性的关系,以探讨MCP-4在RA发病机制中的作用。方法:应用酶联免疫吸附实验(ELISA)定量方法测定40例RA患者、20例其它自身免疫性疾病患者和20例正常健康对照者血清MCP-4水平。分析RA组血清MCP-4水平是否与ESR、CRP、RF及双手放射学检查等指标具有相关性。结果:RA组血清MCP-4水平为(203.79±18.64)pg/mL,其它自身免疫性疾病对照组血清MCP-4水平为(207.76±40.37)pg/mL,正常健康对照组血清MCP-4水平为(125.13±11.08)pg/mL。RA组、其它自身免疫性疾病对照组血清MCP-4水平与正常健康对照组相比均有统计学意义(P lt;0.05),RA组与其它自身免疫性疾病对照组间无统计学意义(P=0.787),RA活动期患者血清MCP-4水平(214.86±24.46)pg/mL和非活动期患者血清MCP-4水平(190.27±29.11)pg/mL比较无统计学意义(P=0.065)。RA组血清MCP-4水平与ESR、CRP、RF及双手X片分期无相关性。结论:RA组的血清MCP-4水平高于正常健康对照组,但与ESR、CRP、RF及双手X片分期无相关性。MCP-4可能参与了RA的发病过程。

Citation： HANG Jie,DONG Jianling,YANG Nanping,et al.. Expression of Monocyte Chemoattractant Protein4 in Rheumatoid Arthritis and its Clinical Significance. West China Medical Journal, 2009, 24(8): 2057-2059. doi: Copy

1.	RADSTAKE T, VANDER R, TEN BRUMMELHUIS M, et al. Increased expression of CCL18, CCL19,and CCL17 by dendritic cells from patients with rheumatoid arthritis,and regulation by Fc γ receptors[J]. Ann Rheum Dis,2005,64:359-367.
2.	SZEKANECZ Z, KOCH A E. Chemokines and angiogenesis[J]. Curr Opin Rheumatol,2001,13:202-208.
3.	SZEKANECZ Z, KOCH A E. Macrophages and their products in rheumatoid arthritis[J]. Curr Opin Rheumatol,2007,19(3):289-295.
4.	VERGUNST C E, TAK P P. Chemokines: their role in rheumatoid arthritis[J]． Curr Rheumatol Rep,2005,7:382-838.
5.	BOUCHAIB, LAMKHIOUED, EDUARDO A, et al. Monocyte chemoattractant protein (MCP)4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines[J]. Am J Respir Crit Care Med,2000,162-723.
6.	TAHA R A, MINSHALL E M, LEUNG D Y, et al. Evidence for increased expression of eotaxin and monocyte chemotactic protein4 in atopic dermatitis[J]. J Allergy Clin Immunol,2000,105:1002-1007.
7.	TAHA R A, LABERGE S, HAMID Q, et al. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein4, and interleukin16 in induced sputum in asthmatic[J]. Patients Chest,2001,120(2):595-601.
8.	ROJASRAINOS E, AVALOS A F, PREZFERNANDEZ L, et al. Role of the chemokines RANTES,monocyte chemotactic proteins3 and 4,and eotaxins1 and 2 in childhood asthma[J]. Eur Respir J,2003,22(2):310-316.
9.	KOCH A E, KUNKEL S L, HARLOW L A, et al. Enhanced production of monocyte chemoattractant protein1 in rheumatoid arthritis[J]. J Clin Invest,1992,90:772-779.
10.	YAO TC, KUO M L, SEE L C, et al. RANTES and monocyte chemoattractant protein 1 as sensitive markers of disease activity in patients with juvenile rheumatoid arthritis: a six year longitudinal study[J]. Arthritis Rheum,2006,54(8):2585-2593.
11.	HATOANO Y, KASAMA T, IWABUCHI H, et al. Macrophage inflammatory protein 1 α expression by synovial fluid neutrophils in rheumatoid arthritis[J]. Ann Rheum Dis,1999,58:297302.
12.	IWAMOTO T, OKAMOTO H, IIKUNI N, et al. Monocyte chemoattractant protein4 (MCP4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis[J]. Rheumatology,2006,45:421-424.
13.	BOUCHAIB L, EDUARDO A, GARCIA Z, et al. Monocyte chemoattractant protein (MCP)4 expression in the airways of patients with asthma[J]. Am J Respir Crit Care Med,2000,162:723.
14.	ERIKSSON C, ENESLATT K, IVANOFF J, et al. Abnormal expression of chemokine receptors on Tcells from patients with systemic lupus erythematosus[J]. Lupus,2003,12:766774.
15.	LIT L, WONG K, TAM S, et al. Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus[J]. Ann Rheum Dis,2006,65:209-215.

1. RADSTAKE T, VANDER R, TEN BRUMMELHUIS M, et al. Increased expression of CCL18, CCL19,and CCL17 by dendritic cells from patients with rheumatoid arthritis,and regulation by Fc γ receptors[J]. Ann Rheum Dis,2005,64:359-367.
2. SZEKANECZ Z, KOCH A E. Chemokines and angiogenesis[J]. Curr Opin Rheumatol,2001,13:202-208.
3. SZEKANECZ Z, KOCH A E. Macrophages and their products in rheumatoid arthritis[J]. Curr Opin Rheumatol,2007,19(3):289-295.
4. VERGUNST C E, TAK P P. Chemokines: their role in rheumatoid arthritis[J]． Curr Rheumatol Rep,2005,7:382-838.
5. BOUCHAIB, LAMKHIOUED, EDUARDO A, et al. Monocyte chemoattractant protein (MCP)4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines[J]. Am J Respir Crit Care Med,2000,162-723.
6. TAHA R A, MINSHALL E M, LEUNG D Y, et al. Evidence for increased expression of eotaxin and monocyte chemotactic protein4 in atopic dermatitis[J]. J Allergy Clin Immunol,2000,105:1002-1007.
7. TAHA R A, LABERGE S, HAMID Q, et al. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein4, and interleukin16 in induced sputum in asthmatic[J]. Patients Chest,2001,120(2):595-601.
8. ROJASRAINOS E, AVALOS A F, PREZFERNANDEZ L, et al. Role of the chemokines RANTES,monocyte chemotactic proteins3 and 4,and eotaxins1 and 2 in childhood asthma[J]. Eur Respir J,2003,22(2):310-316.
9. KOCH A E, KUNKEL S L, HARLOW L A, et al. Enhanced production of monocyte chemoattractant protein1 in rheumatoid arthritis[J]. J Clin Invest,1992,90:772-779.
10. YAO TC, KUO M L, SEE L C, et al. RANTES and monocyte chemoattractant protein 1 as sensitive markers of disease activity in patients with juvenile rheumatoid arthritis: a six year longitudinal study[J]. Arthritis Rheum,2006,54(8):2585-2593.
11. HATOANO Y, KASAMA T, IWABUCHI H, et al. Macrophage inflammatory protein 1 α expression by synovial fluid neutrophils in rheumatoid arthritis[J]. Ann Rheum Dis,1999,58:297302.
12. IWAMOTO T, OKAMOTO H, IIKUNI N, et al. Monocyte chemoattractant protein4 (MCP4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis[J]. Rheumatology,2006,45:421-424.
13. BOUCHAIB L, EDUARDO A, GARCIA Z, et al. Monocyte chemoattractant protein (MCP)4 expression in the airways of patients with asthma[J]. Am J Respir Crit Care Med,2000,162:723.
14. ERIKSSON C, ENESLATT K, IVANOFF J, et al. Abnormal expression of chemokine receptors on Tcells from patients with systemic lupus erythematosus[J]. Lupus,2003,12:766774.
15. LIT L, WONG K, TAM S, et al. Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus[J]. Ann Rheum Dis,2006,65:209-215.

West China Medical Journal

Expression of Monocyte Chemoattractant Protein4 in Rheumatoid Arthritis and its Clinical Significance

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