An Analysis of Clinical Characteristics of 46 Women with Ankylosing Spondylitis_West China Medical Journal

Authors：

ZHONG Xue , YANG Min , YANG Nanping.

the Department of Clinical Immunology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

女性; 强直性脊柱炎; 临床特点

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目的:探讨女性强直性脊柱炎患者的临床特点。方法:回顾性分析华西医院风湿免疫科2003年1月1日至2009年1月1日住院收治的女性强直性脊柱炎患者住院病历共计46例,抽取与女性患者入院时间及病程大致相等的男性病历40例,记录发病年龄、病程、首发症状、临床表现、实验室检查,并对两组数据进行比较,调查女性患者中血小板计数与血沉、C-反应蛋白、球蛋白的相互关系。结果:发病年龄女性组为(30±11)岁,男性组为(24±7)岁(P＝0.003);首发症状、主要临床表现、关节活动受限和病情活动指标在两组无统计学差异(P gt;0.05)。相关分析显示,血小板计数与C-反应蛋白、血沉、球蛋白分别存在较好的正相关关系(C反应蛋白:r=0.608,P=0.000;血沉:r=0.558,P=0.000;球蛋白r=0.411,P=0.005)。女性组中HLAB27阳性患者与阴性患者的年龄差异无统计学意义(P＞0.05)。结论:女性强直性脊柱患者的发病年龄大于男性,患者的血小板计数有助于评价病情活动。

Citation： ZHONG Xue,YANG Min,YANG Nanping.. An Analysis of Clinical Characteristics of 46 Women with Ankylosing Spondylitis. West China Medical Journal, 2009, 24(8): 2081-2083. doi: Copy

1.	LEE J H, JUN J B, JUNG S, et al. Higher prevalence of peripheral arthritis among ankylosing spondylitis patients[J]. J Korean Med Sci,2002,17(5):669-673.
2.	ROUF J, STUCKI G. Validity aspects of erythrocyte sedimentation rate and Creactive protein in ankylosing spondylitis: a literature review[J]. J Rheumatology,1999,26:966-970.
3.	LUKAS C, LANDEW R, SIEPER J, et al. Development of an ASASendorsed disease activity score (ASDAS) in patients with ankylosing spondylitis[J]. Ann Rheum Dis,2009,68(1):1824.
4.	王俊祥,顾光,陈海英,等.血小板参数与强直性脊柱炎病情活动的相关性研究[J].河北医药,2008, 30(4):472-473.
5.	WANG F, YAN C G, XIANG H Y, et al. The significance of platelet activation in ankylosing spondylitis[J]. Clin Rheumatol,2008,27:767-769.
6.	王兴茂,朱玉琴,朱桂英,等,强直性脊柱炎并血小板增多症一例报告[J].中国临床实验室,2002,1(2):20.
7.	GRAN J T, HUSBY G. Ankylosing spondylitis in women[J]. Seminars Arthritis Rheum,1991,19 (5):303-312.
8.	LEE W, REVEILLE J D, WEISMAN M H, et al. Women with ankylosing spondylitis: a review[J]. Arthritis Rheum,2008,59(3):449-454.
9.	张剑波,周彬,吴小丹,等.四川地区汉族强直性脊柱炎患者HLAB27抗原阳性频率和表达强度的联合观察[J].四川医学,2008,29(8):1071-1074.
10.	曾宪国,刘湘源.女性与男性强直性脊柱炎对比研究[J].医学文选,2001,15(6):132-134.
11.	倪吴花,胡晓霞,章圣辉,等.强直性脊柱炎867例HLAB27的表达及意义[J].实用医学杂志,2008 24 (9): 1511-1513.
12.	JAAKKOLA E, HERZBERG I, LAIHO K, et al. Finnish HLA studies confirm the increased risk conferred by HLAB27 homozygosity in ankylosing spondylitis[J]. Ann Rheum Dis,2006,65: 775-80.
13.	STENSEN M, FRGER F, NELSON J L, et al. Pregnancy in patients with rheumatic disease: antiinflammatory cytokines increase in pregnancy and decrease post partum[J]. Ann Rheum Dis,2005,64(6):839-844.

1. LEE J H, JUN J B, JUNG S, et al. Higher prevalence of peripheral arthritis among ankylosing spondylitis patients[J]. J Korean Med Sci,2002,17(5):669-673.
2. ROUF J, STUCKI G. Validity aspects of erythrocyte sedimentation rate and Creactive protein in ankylosing spondylitis: a literature review[J]. J Rheumatology,1999,26:966-970.
3. LUKAS C, LANDEW R, SIEPER J, et al. Development of an ASASendorsed disease activity score (ASDAS) in patients with ankylosing spondylitis[J]. Ann Rheum Dis,2009,68(1):1824.
4. 王俊祥,顾光,陈海英,等.血小板参数与强直性脊柱炎病情活动的相关性研究[J].河北医药,2008, 30(4):472-473.
5. WANG F, YAN C G, XIANG H Y, et al. The significance of platelet activation in ankylosing spondylitis[J]. Clin Rheumatol,2008,27:767-769.
6. 王兴茂,朱玉琴,朱桂英,等,强直性脊柱炎并血小板增多症一例报告[J].中国临床实验室,2002,1(2):20.
7. GRAN J T, HUSBY G. Ankylosing spondylitis in women[J]. Seminars Arthritis Rheum,1991,19 (5):303-312.
8. LEE W, REVEILLE J D, WEISMAN M H, et al. Women with ankylosing spondylitis: a review[J]. Arthritis Rheum,2008,59(3):449-454.
9. 张剑波,周彬,吴小丹,等.四川地区汉族强直性脊柱炎患者HLAB27抗原阳性频率和表达强度的联合观察[J].四川医学,2008,29(8):1071-1074.
10. 曾宪国,刘湘源.女性与男性强直性脊柱炎对比研究[J].医学文选,2001,15(6):132-134.
11. 倪吴花,胡晓霞,章圣辉,等.强直性脊柱炎867例HLAB27的表达及意义[J].实用医学杂志,2008 24 (9): 1511-1513.
12. JAAKKOLA E, HERZBERG I, LAIHO K, et al. Finnish HLA studies confirm the increased risk conferred by HLAB27 homozygosity in ankylosing spondylitis[J]. Ann Rheum Dis,2006,65: 775-80.
13. STENSEN M, FRGER F, NELSON J L, et al. Pregnancy in patients with rheumatic disease: antiinflammatory cytokines increase in pregnancy and decrease post partum[J]. Ann Rheum Dis,2005,64(6):839-844.

West China Medical Journal

An Analysis of Clinical Characteristics of 46 Women with Ankylosing Spondylitis

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