The Effect of Hypoxic Preconditioning on Old Rat Model of Postoperative Fatigue Syndrome Caused by Excision of Bilateral Accessory and Hysterectomy_West China Medical Journal

Authors：

ZENG Yan ¹ , JIANG Jing ¹ , WANG Yu ²

1the Department of Gynecology, Chengdu Railway Central Hospital, Chengdu 610081; 2the Department of Sport Medcine, Chengdu Institute of Physical Education, Chengdu 610041, China;

Corresponding author：

Keywords：

手术后疲劳综合征; 缺氧预处理; 超氧化物歧化酶; 丙二醛

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目的:研究缺氧预处理对老年大鼠子宫及双附件切除术后疲劳是否有改善作用,并通过对比观察超氧化物歧化酶及丙二醛水平的变化,初步探讨缺氧预处理的作用机制。方法:将老年大鼠分为空白对照组、对照组、缺氧预处理三组。空白对照组为假手术组,对照组为子宫及双附件切除术组, 缺氧预处理组为缺氧预处理加子宫及双附件切除术组。对比观察缺氧预处理对大鼠体力活动及血清超氧化物歧化酶和丙二醛水平的影响。结果:空白对照组、对照组、缺氧预处理三组大鼠悬尾不动时间分别为:(21±3)s,(83±10)s,(44±5)s,各组间比较P lt;0.05。三组SOD活性分别为:(131.23±5.31)U/L,(36.12±9.68)U/L,(73.01±9.82)U/L,各组间比较P lt;0.05。三组MDA水平分别为:(9.78±1.26)μmol/L,(29.87±3.13)μmol/L,(15.98±2.21)μmol/L,各组间比较P lt;0.05。结论:缺氧预处理可提高老年大鼠的抗氧化能力,对老年大鼠子宫及双附件切除术后疲劳综合征有明显的改善作用。

Citation： ZENG Yan,JIANG Jing,WANG Yu. The Effect of Hypoxic Preconditioning on Old Rat Model of Postoperative Fatigue Syndrome Caused by Excision of Bilateral Accessory and Hysterectomy. West China Medical Journal, 2009, 24(8): 2095-2097. doi: Copy

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1. RUBIN G J, HOTOPF M. Systematic review and metaanalysis of interventions for postoperative fatigue[J]. Br J Surg,2002,89(8):971-984.
2. MURRY C E, JENNING R B, REIMER K A. Preconditioning with ischmia: a delay of cell injury in ischemic myocardium[J]. Circulation,1986,74(5):1124-1136.
3. CHRISTENSEN T, KEHLET H. Postoperative fatigue[J].World J Surg,1993,17(2):220-225.
4. SALMON P, HALL G M. A theory of postoperative fatigue[J]. J R Soc Med,1997,90(12):661-664.
5. TSUTUI H. Oxidative stress in heart failure: the role of mitochondria[J]. Intern Med,2001,40 (12): 1177-1182.
6. CHANDRA M, SURENDRA K, KAPOOR R K, et al. Oxidant stress mechanisms in heart failure[J]. Boll Chim Farm,2000,139(3):149-152.
7. GLOSLI H, TRONSTAD K J, WERGEDAL H, et al. Human TNFα in transgenic mice induces differential changes in redox status and glutathioneregulating enzymes[J]. FASEB J,2002,16(11):1450-1452.
8. MALAPLATEARMAND C, GUEGUEN Y, BERTRAND P, et al. U373MG response to interleukin1βinduced oxidative stress[J]. Cell Biol Toxicol,2000,16(3):155-163.
9. IHNKEN K, WINKLERA, SCHLENSAK C, et al. Normoxic cardiopulmonary bypass reduces oxidative myocardial damage and nitric oxide during cardiac operations in the adult[J]. J Thorac Cardiovasc Surg,1998,116(2):327-334.

West China Medical Journal

The Effect of Hypoxic Preconditioning on Old Rat Model of Postoperative Fatigue Syndrome Caused by Excision of Bilateral Accessory and Hysterectomy

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