Expression of Fascin Correlates with the Invasion of Pituitary Adenoma_West China Medical Journal

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1Department of Neurosurgery, West China Hospital, Sichuuan University, Chengdu Sichuan 610041, China;

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Keywords：

垂体瘤; 侵袭性; 肌动蛋白捆绑蛋白

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目的:对照研究Fascin在侵袭性和非侵袭性垂体瘤中的表达差异,探讨Fascin的表达与垂体瘤侵袭性的关系。方法:应用Envision二步免疫组化方法,通过测定各样本平均光密度值和积分光密度值,比较侵袭性和非侵袭性垂体腺瘤、不同病理类型、不同体积肿瘤中Fascin的表达差异。结果:Fascin在侵袭性垂体腺瘤的表达明显高于非侵袭性垂体腺瘤,其表达水平与垂体腺瘤的侵袭性正相关,巨大型肿瘤的表达明显高于小型肿瘤,不同病理类型之间无显著差异。结论:Fascin的表达与垂体腺瘤的侵袭生长有关,与垂体瘤大小有关,与病理类型无关。

Citation： WANG Chengde,WANG Xiujie,JIANG Shu,et al.. Expression of Fascin Correlates with the Invasion of Pituitary Adenoma. West China Medical Journal, 2009, 24(9): 2225-2227. doi: Copy

1.	[5JAWHARI A U, BUDA A, JENKINS M, et al. Fascin, an actinbundling protein, modulatescolonic epithelial cell invasiveness and differentiation in vitro[J]. Am J Pathol,2003,162:69-80.
2.	EDWARDS R A, BRYAN J. Fascins, a family of actin bundling proteins[J]. Cell Motility Cytoskeleton,1995,32:1-9.
3.	RUTKA J, HWANG J, SMITH C, et al. The role of Fascin in the migration and invasiveness of malignant gliomas[J]. J Neurosurg Pediatrics, 2008,1(4):A354.
4.	ANDRES A, ROMA RICHARD A, PRAYSON. Fascin expression in 90patient with glioblastoma multiforme[J]. Annals of Diagnostic Pathology,2005, 9:307-311.
5.	ADAMS J C, KUREISHY N, TAYLOR A L. A role for syndecan1 in coupling Fascin spike formation by thrombospondin1[J]. Journal of Cell Biology, 2001,152: 1169-1182.
6.	HASHIMOTO Y, ITO T, INOUE H, et al. Prognostic significance of Fascin overexpression in human esophageal squamous cell carcinoma[J]. Clin Cancer Res,2005,11:2597-2605.
7.	AOUDJIT F, VUORI K. Integrin signaling inhibits paclitaxel  induced apoptosis in breast cancer cells[J]. Oncogene,2001,20(36):4995 -5004.
8.	万峰,舒凯,雷霆,等.整合素β1、局灶粘附激酶的表达与垂体瘤侵袭性的关系[J].中国临床神经外科杂志,2002,7(5):265-267.
9.	NUSSER N, GOSMANOVA E, ZHENG Y, et al.Nerve groeth factor singnals through TrkA, ohesohatidylinostiol 32 kinase, and Racl to in active RhoA during the intiation of neuronal differentiation of PC12 cells[J]. J Biol Chem,2002,277(39):35840-35846.
10.	PELOSI G, PASTORINO U, PASINI F, et al. Independent prognostic value of Fascin immunoreactivity in stage I nonsmall cell lung cancer[J]. Br J Cancer,2003,88:537-547.
11.	HASHIMOTO Y, SHIMADA Y, KAWAMURA J, et al. The prognostic relevance of Fascin expressionin human gastric carcinoma[J]. Oncology,2004,67:262-270.
12.	YOSUKE HASHIMOTO A, MAREK SKACEL B, JOSEPHINE C, et al. Roles of Fascin in human carcinoma motility and signaling: Prospects for a novel biomarker?[J] Internat J Biochem Cell Biol,2005,37:1787-1804.
13.	MAHTA A, HAGHPANAH V, LASHKARI A, et al. Nonfunctioning pituitary adenoma: immunohistochemical analysis of 85 cases. Dr. Shariati Hospital, North Kargar Avenue, Tehran, Iran..
14.	刘伟,杨树源,于士柱.Ki67抗原表达与垂体腺瘤增殖活性及侵袭性关系的研究[J].中国现代神经疾病杂志,2004,4(1):45-48.

1. [5JAWHARI A U, BUDA A, JENKINS M, et al. Fascin, an actinbundling protein, modulatescolonic epithelial cell invasiveness and differentiation in vitro[J]. Am J Pathol,2003,162:69-80.
2. EDWARDS R A, BRYAN J. Fascins, a family of actin bundling proteins[J]. Cell Motility Cytoskeleton,1995,32:1-9.
3. RUTKA J, HWANG J, SMITH C, et al. The role of Fascin in the migration and invasiveness of malignant gliomas[J]. J Neurosurg Pediatrics, 2008,1(4):A354.
4. ANDRES A, ROMA RICHARD A, PRAYSON. Fascin expression in 90patient with glioblastoma multiforme[J]. Annals of Diagnostic Pathology,2005, 9:307-311.
5. ADAMS J C, KUREISHY N, TAYLOR A L. A role for syndecan1 in coupling Fascin spike formation by thrombospondin1[J]. Journal of Cell Biology, 2001,152: 1169-1182.
6. HASHIMOTO Y, ITO T, INOUE H, et al. Prognostic significance of Fascin overexpression in human esophageal squamous cell carcinoma[J]. Clin Cancer Res,2005,11:2597-2605.
7. AOUDJIT F, VUORI K. Integrin signaling inhibits paclitaxel  induced apoptosis in breast cancer cells[J]. Oncogene,2001,20(36):4995 -5004.
8. 万峰,舒凯,雷霆,等.整合素β1、局灶粘附激酶的表达与垂体瘤侵袭性的关系[J].中国临床神经外科杂志,2002,7(5):265-267.
9. NUSSER N, GOSMANOVA E, ZHENG Y, et al.Nerve groeth factor singnals through TrkA, ohesohatidylinostiol 32 kinase, and Racl to in active RhoA during the intiation of neuronal differentiation of PC12 cells[J]. J Biol Chem,2002,277(39):35840-35846.
10. PELOSI G, PASTORINO U, PASINI F, et al. Independent prognostic value of Fascin immunoreactivity in stage I nonsmall cell lung cancer[J]. Br J Cancer,2003,88:537-547.
11. HASHIMOTO Y, SHIMADA Y, KAWAMURA J, et al. The prognostic relevance of Fascin expressionin human gastric carcinoma[J]. Oncology,2004,67:262-270.
12. YOSUKE HASHIMOTO A, MAREK SKACEL B, JOSEPHINE C, et al. Roles of Fascin in human carcinoma motility and signaling: Prospects for a novel biomarker?[J] Internat J Biochem Cell Biol,2005,37:1787-1804.
13. MAHTA A, HAGHPANAH V, LASHKARI A, et al. Nonfunctioning pituitary adenoma: immunohistochemical analysis of 85 cases. Dr. Shariati Hospital, North Kargar Avenue, Tehran, Iran..
14. 刘伟,杨树源,于士柱.Ki67抗原表达与垂体腺瘤增殖活性及侵袭性关系的研究[J].中国现代神经疾病杂志,2004,4(1):45-48.

West China Medical Journal

Expression of Fascin Correlates with the Invasion of Pituitary Adenoma

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