Clinical Investigation on Treating Arteriosclerotic Cerebral Infarction Combined with Hyperlipemia by Prubucol_West China Medical Journal

Authors：

1Nong Jiu Shi Hospital, Xinjiang Army, Emin Xinjiang 834601; 2 Department of Neurology, Jiangyou People’s Hospital, Jiangyou Sichuan 621700; 3Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

普罗布考; 脑梗死; 高脂血症; 心脑血管病

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目的:探讨普罗布考对动脉粥样硬化性脑梗死并高脂血症患者血脂及预后的影响。方法:将87例脑梗死并高脂血症患者随机分为两组,治疗组44例,对照组43例,两组除按动脉粥样硬化性脑梗死常规治疗外,停用一切降脂药物。治疗组给予普罗布考500mg bid/d。疗程为6个月。随访一年观察两组患者治疗后血脂水平及脑血管事件发生情况。结果:治疗组患者治疗前、后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)间差异均有显著性意义(P lt;0.05)。两组患者治疗后各项血脂指标间差异均有显著性意义(P lt;0.05)。随访一年,显示治疗组患者心脑血管事件14次,对照组19次(P lt;0.05)。结论:普罗布考降脂疗效可靠、副作用轻微,降低心脑血管事件发生。可作为动脉粥样硬化性脑梗死并高脂血症患者的一、二级预防药物。

Citation： XIAO Weijun,ZHANG Hao,XU Pingrong.. Clinical Investigation on Treating Arteriosclerotic Cerebral Infarction Combined with Hyperlipemia by Prubucol. West China Medical Journal, 2009, 24(9): 2234-2236. doi: Copy

1.	YOKOYAMA T, MIYAUCHI K, KURATA T. Effect of probucol on neointimal thickening in a stent porcine restenosis model[J]. Jpn Heart J, 2004, 45(2):305-13.
2.	贾伟华,周立春,田桂林. 普罗布考对颈动脉粥样硬化斑块稳定性影响的临床研究[J].中国新药杂志, 2007,16:237-239.
3.	FORTI N, RAMIRES JA. Effects of lovastatin and probucol on lipoprotein fractions in patients with hypercholesterolemia. A Brazilian multicenter study[J]. Arq Bras Cardiol, 1991, 57(3):25361.
4.	JEON SM, PARK YB, KWON OS, et al. Vitamin E supplementation alters HDLcholesterol concentration and paraoxonase activity in rabbits fed highcholesterol diet: comparison with probucol[J]. J Biochem Mol Toxicol, 2005, 19(5):336-46.
5.	HONG SC, ZHAO SP, WU ZH. Effect of probucol on HDL metabolism and class B type I scavenger receptor (SRBI) expression in the liver of hypercholesterolemic rabbits[J]. Int J Cardiol, 2007, 115(1):29-35.
6.	傅琛,夏强,曹春梅,等.活性氧,NO和线粒体ATP敏感钾通道在TNF2A预处理对缺血/再灌注心肌保护中的作用[J].中国应用生理学杂志,2005,21(1):20-24.
7.	HONG SC, ZHAO SP, WU ZH.Probucol upregulates paraoxonase 1 expression in hepatocytes of hypercholesterolemic rabbits[J]. J Cardiovasc Pharmacol, 2006, 47(1):77-81.
8.	顾江涛,屈文昌,张安,丙丁酚对冠心病及其高位人群血管内皮功能失调的作用[J].临床心血管病杂志, 2006,22(2):117-118.
9.	FRUEBIS J, SILVESTRE M, SHELTON D, et al. Inhibition of VCAM1 expression in the arterial wall is shared by structurally different antioxidants that reduce early atherosclerosis in NZW rabbits[J]. J Lipid Res, 1999, 40(11):1958-66.
10.	ADLOUNI A, EL MESSAL M, SA?LE R. Probucol promotes reverse cholesterol transport in heterozygous familial hypercholesterolemia. Effects on apolipoprotein AIcontaining lipoprotein particles[J]. Atherosclerosis, 2000,152(2):433-40.
11.	SUKHOVA GK, SCH?NBECK U, RABKIN E. Evidence for increased collagenolysis by interstitial collagenases1 and 3 in vulnerable human atheromatous plaques[J]. Circulation, 1999,18; 99(19):2503-9.

1. YOKOYAMA T, MIYAUCHI K, KURATA T. Effect of probucol on neointimal thickening in a stent porcine restenosis model[J]. Jpn Heart J, 2004, 45(2):305-13.
2. 贾伟华,周立春,田桂林. 普罗布考对颈动脉粥样硬化斑块稳定性影响的临床研究[J].中国新药杂志, 2007,16:237-239.
3. FORTI N, RAMIRES JA. Effects of lovastatin and probucol on lipoprotein fractions in patients with hypercholesterolemia. A Brazilian multicenter study[J]. Arq Bras Cardiol, 1991, 57(3):25361.
4. JEON SM, PARK YB, KWON OS, et al. Vitamin E supplementation alters HDLcholesterol concentration and paraoxonase activity in rabbits fed highcholesterol diet: comparison with probucol[J]. J Biochem Mol Toxicol, 2005, 19(5):336-46.
5. HONG SC, ZHAO SP, WU ZH. Effect of probucol on HDL metabolism and class B type I scavenger receptor (SRBI) expression in the liver of hypercholesterolemic rabbits[J]. Int J Cardiol, 2007, 115(1):29-35.
6. 傅琛,夏强,曹春梅,等.活性氧,NO和线粒体ATP敏感钾通道在TNF2A预处理对缺血/再灌注心肌保护中的作用[J].中国应用生理学杂志,2005,21(1):20-24.
7. HONG SC, ZHAO SP, WU ZH.Probucol upregulates paraoxonase 1 expression in hepatocytes of hypercholesterolemic rabbits[J]. J Cardiovasc Pharmacol, 2006, 47(1):77-81.
8. 顾江涛,屈文昌,张安,丙丁酚对冠心病及其高位人群血管内皮功能失调的作用[J].临床心血管病杂志, 2006,22(2):117-118.
9. FRUEBIS J, SILVESTRE M, SHELTON D, et al. Inhibition of VCAM1 expression in the arterial wall is shared by structurally different antioxidants that reduce early atherosclerosis in NZW rabbits[J]. J Lipid Res, 1999, 40(11):1958-66.
10. ADLOUNI A, EL MESSAL M, SA?LE R. Probucol promotes reverse cholesterol transport in heterozygous familial hypercholesterolemia. Effects on apolipoprotein AIcontaining lipoprotein particles[J]. Atherosclerosis, 2000,152(2):433-40.
11. SUKHOVA GK, SCH?NBECK U, RABKIN E. Evidence for increased collagenolysis by interstitial collagenases1 and 3 in vulnerable human atheromatous plaques[J]. Circulation, 1999,18; 99(19):2503-9.

West China Medical Journal

Clinical Investigation on Treating Arteriosclerotic Cerebral Infarction Combined with Hyperlipemia by Prubucol

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