Research on the Expressions of PGSK-3β, CEA and C-myc in Non-small Cell Lung Cancer and their Relationship_West China Medical Journal

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1the Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, China;

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Keywords：

肺癌; PGSK-3; CEA; C-myc

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目的:研究非小细胞肺癌中PGSK-3β、CEA、C-myc的表达,探讨它们与肺癌临床病理因素的相关性及在肺癌中三指标之间的相关性。方法:运用免疫组化法检测90例肺癌PGSK-3β、CEA、C-myc的表达情况。结果肺腺癌PGSK-3β阳性率明显高于鳞癌(P lt;0.05),临床Ⅲ-Ⅳ期阳性率显著高于Ⅰ-Ⅱ期(P lt;0.05)。周围型肺癌CEA阳性率显著高于中央型肺癌(P lt;0.01),有淋巴结转移者阳性率显著高于无淋巴结转移者(P lt;0.05)。肺癌中、低分化组C-myc阳性率显著高于高分化组(P lt;0.05);C-myc阳性强度表达呈抛物线状趋势,在中分化组显著高于低分化组和高分化组。肺癌中PGSK-3β与CEA表达呈正相关(P lt;0.05)。结论:PGSK-3β促进肺癌的演进过程,与肺癌的分化、分期相关。肺癌高表达CEA时癌组织异质性粘附增加,有利于其浸润与转移。肺癌中C-myc表达增加是肺癌发生中的常见分子事件,与癌细胞分化有关。肺癌中PGSK-3β与CEA表达呈正相关。

Citation： WANG Geping,CHEN Li. Research on the Expressions of PGSK-3β, CEA and C-myc in Non-small Cell Lung Cancer and their Relationship. West China Medical Journal, 2009, 24(9): 2320-2323. doi: Copy

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1. JIA J H, AMANAI K, WANG G L, et al. Shaggy/GSK3 antagonizes Hedgehog signaling by regulating Cubitus interruptus[J]. Nature, 2002, 416(6880): 548 -552.
2. SOTOCERRATO V,VINALS F,LAMBERT JR,et al. Prodigiosin induces the proapoptotic gene NAG1 via glycogen synthase kinase3β activity in breast cancer cells[J]. Mol Cancer Ther, 2007, 6 (1): 362-369.
3. LI J, MIZUKAMI Y, ZHANG X, et al.Oncogenic Kras stimulates Wnt singaling in colon cancer through inhibition of GSK3[J]. J Gastroenterology, 2005, 128 (7):1907-1918.
4. LEI SA, DUBEYKOVSKIY A, CHAKLADAR L, et al. The murine gastrin promoter is synergistically activated by transforming growth factorβ/ SMAD and Wnt signaling pathways[J]. J Biol Chem, 2004, 279 (41): 42492-42502.
5. DING VW, CHEN RH,MCCORMICK FJ. Differential regulation of glycogen synthase kinase3βby insulin and wnt signaling[J]. Biol Chem, 2000, 275 (42): 32475-32481.
6. LIANG J, SLINGERLAND J M. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycleprogression[J]. Cell Cycle, 2003, 2 (4):339-345.
7. ALT J R, CLEVELAND J L, HANNINK M, et al. Phosphorylation dependent regulation of cyclinD1 nuclear export and cyclinD1dependent cellular transformation[J]. Genes Dev, 2000,14 (24):3102-3114.
8. BAN KC, SINGH H, KRISHNAN R, et al. GSK3 β phosphorylation and alteration of βcatenin in hepatocellularcarcinoma[J]. Cancer Lett, 2003, 199 (2): 201-208.
9. GOTO H, KAWANO K, KOBAYASHI I, et al. Expression of cyclin D1 and GSK3β and their predictivevalue of prognosis in squamous cell carcinomas of the tongue[J].Oral Oncol, 2002, 38 (6): 549-556.
10. HA N C, TONOZUKA T, STAMOS J L, CHOI HJ, WEIS W I. Mechanism of phosphorylationdependent binding of APC to βcatenin and its role in βcatenin degradation[J]. Mol Cell, 2004, 15 (4): 511-521.
11. 王志新, 高明发. 非小细胞肺癌癌胚抗原表达的临床意义[J]. 第三军医大学学报, 2001, 23 (1): 102-104.
12. LU LX, JIANG HC, ZHU AL. Gene expression profiles in liver cancer and normal liver tissues[J]. World J Gastroenterol, 2000, 6 (suppl3): 85.
13. WANG Q, LIN ZY, FENG XL. Alterations in metastatic properties of hepat ocellular carcinoma cell following oncogene transfection[J].World J Gastroentero L, 2001, 7 (3): 335-339.
14. LI J, MIZUKAMI Y, ZHANG X, et al.Oncogenic Kras stimulates Wnt singaling in colon cancer through inhibition of GSK3β[J]. J Gastroenterology, 2005, 128 (7): 1907-1918.
15. XU AG, LI SG, LIU J H, et al.Function of apoptosis and expression of he proteins Bcl2, p53 and Cmyc in the development of gastric cancer[J]. World J Gastroenterol, 2001, 7 (3): 403406.

West China Medical Journal

Research on the Expressions of PGSK-3β, CEA and C-myc in Non-small Cell Lung Cancer and their Relationship

Abstract Full text Figures/Tables Video References Cited by

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