Application for Misoprostol Before Induced Abortion for the First Early Pregnancy_West China Medical Journal

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Sichuan Provincial Hospital for Women and Children,Chengdu 610031,China;

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Keywords：

米索前列醇片; 早孕; 流产; 阴道内; 口服

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目的:探讨米索前列醇片在初次早早孕(≤42天)人工流产术前应用的可行性、有效性及安全性。方法:将300例初次妊娠,孕周≤6周,拟行人工流产的妇女随机分为口服米索组100例(A组)、阴道放置米索组100例(B组)、未使用米索对照组(C组)。A组术前2h口服米索前列醇片400 μg,B组术前2h阴道放置米索前列醇片400 μg。观察并比较术前用药的两组不良反应发生率、宫颈扩张效果、术中出血量、手术时间及术后宫颈粘连发生情况。结果:B组不良反应发生率低于A组,差异有统计学意义(P lt;0.01);A、B两组间术中宫颈扩张效果、术中出血量、手术时间及术后宫颈粘连发生率差异均无统计学意义(P gt;0.05),但与C组比较差异有统计学意义。结论:米索前列醇片口服和阴道放药都可作为初次早早孕人工流产术前的给药方法。更推荐不良反应较小的阴道放药。

Citation： WANG Xiaoyin,LIU Jingtao,XU Zhou.. Application for Misoprostol Before Induced Abortion for the First Early Pregnancy. West China Medical Journal, 2009, 24(9): 2405-2407. doi: Copy

1.	VIMALA N, MITAL S, KUMAR S. Sublingual misoprostol for preabortion cervical ripening in firsttrimester pregnancy termination[J].Contraception,2003,67(4):295-297.
2.	TANG, O S, H O, P C. The use of misoprostol for early pregnancy failure[J].Current opinion in obstetrics & gynecology,2006,18:163.
3.	CREININ M D, HUANG X, WESTHOFF C. Factors related to successful misoprostol treatment for early pregnancy failure[J]. Obstetrics & Gynecology,2006,107(4):1215.
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6.	GUIX C, PALACIO M, FIGUERAS F. Efficacy of two regimens of misoprostol for early secondtrimester pregnancy termination[J]. Fetal diagnosis and therapy, 2005,20:617.
7.	FICIOGUL C, TASDEMIR M, T ASDEMIRS. Effect of vaginal misoprostol application for cervical softening in pregnancy interruption before ten weeks of gestation[J]. Acta Obstet Gynecol Scand,1996, 75:54.

1. VIMALA N, MITAL S, KUMAR S. Sublingual misoprostol for preabortion cervical ripening in firsttrimester pregnancy termination[J].Contraception,2003,67(4):295-297.
2. TANG, O S, H O, P C. The use of misoprostol for early pregnancy failure[J].Current opinion in obstetrics & gynecology,2006,18:163.
3. CREININ M D, HUANG X, WESTHOFF C. Factors related to successful misoprostol treatment for early pregnancy failure[J]. Obstetrics & Gynecology,2006,107(4):1215.
4. DAVIS A R, ROBILOTTO C M, WESTHOFF C L. Bleeding patterns after vaginal misoprostol for treatment of early pregnancy failure[J].Human reproduction, 2004, 19:216.
5. VONHERTZEN, H, PIAGGIO, G, HUONG, N T. Efficacy of two intervals and two routes of administration of misoprostol for termination of early pregnancy: a randomised controlled equivalence trial[J].The Lancet, 2007,15:369.
6. GUIX C, PALACIO M, FIGUERAS F. Efficacy of two regimens of misoprostol for early secondtrimester pregnancy termination[J]. Fetal diagnosis and therapy, 2005,20:617.
7. FICIOGUL C, TASDEMIR M, T ASDEMIRS. Effect of vaginal misoprostol application for cervical softening in pregnancy interruption before ten weeks of gestation[J]. Acta Obstet Gynecol Scand,1996, 75:54.

West China Medical Journal

Application for Misoprostol Before Induced Abortion for the First Early Pregnancy

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