Efficacy of Granisetron in Preventing Postanesthetic Shivering_West China Medical Journal

Authors：

ZHANG Yonghong , YANG Tianfeng , TANG Xiaofeng.

Department of Anesthesiology, Central Hospital of Mianyang City, Sichuan Mianyang 610041,China;

Corresponding author：

Keywords：

格拉斯琼; 曲马多; 格拉斯琼; 寒战

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目的:探讨同哌替啶和曲马多比较,格拉斯琼预防全麻后寒战的临床效果。方法:120例ASA I～II级,在全麻下拟行择期手术患者,随机分为四组,每组30例:T组(曲马多1 mg/kg),G组(格拉斯琼40 μg/kg),M组(哌替啶0.4 mg/kg)和P组(0.9%生理盐水)。各组药物在手术结束时通过静脉给予。记录术后寒战评分和麻醉恢复时间及镇静程度。结果:同对照组比较,格拉斯琼明显减少麻醉后寒战的发生(P＜0.01),但同哌替啶和曲马多组比较无统计学差异(P ＞0.05)。哌替啶组和曲马多组的麻醉恢复时间(20.58±3.56和16.45 ±4.13 min)较对照组(12.61 ± 3.31 min)和格拉斯琼组(13.58 ± 3.41 min)明显延长(P＜0.05)。结论:使用40 μg/kg格拉司琼同使用曲马多1 mg/kg和哌替啶0.4 mg/kg一样可有效地预防麻醉后寒战。

Citation： ZHANG Yonghong,YANG Tianfeng,TANG Xiaofeng.. Efficacy of Granisetron in Preventing Postanesthetic Shivering. West China Medical Journal, 2009, 24(10): 2540-2542. doi: Copy

1.	MATHEWS S, AL MULLA A, VARGHESE PK, et al. Postanaesthetic shivering: a new look at tramadol [J]. Anaesthesia, 2002, 57: 394-398.
2.	PIPER S N, SUTTNER S W, SCHMIDT C C, et al. Nefopam and clonidine in the prevention of postanaesthetic shivering [J]. Anaesthesia, 1999,54: 695-699.
3.	SAGIR O, GULHAS N, TOPRAK H, et al. Control of shivering during regional anaesthesia: prophylactic ketamine and granisetron [J]. Acta Anaesthesiol Scand, 2007,51: 44-49.
4.	HORN E P, STANDL T, SESSLER D I, et al. Physostigmine prevents postanesthetic shivering as does meperidine or clonidine [J]. Anesthesiology, 1998,88: 108-113.
5.	WANG J J, HO S T, LEE S C, et al. A comparison among nalbuphine, meperidine, and placebo for treating postanesthetic shivering [J]. Anesth Analg, 1999,88: 686-689.
6.	IKEDA T, SESSLER D I, TAYEFEH F, et al. Meperidine and alfentanil do not reduce the gain or maximum intensity of shivering [J]. Anesthesiology, 1998,88: 858-865.
7.	WRENCH I J, SINGH P, DENNIS A R, et al. The minimum effective doses of pethidine and doxapram in the treatment of postanaesthetic shivering [J]. Anaesthesia, 1997, 52: 32-36.
8.	ALFONSI P, SESSLER D I, DU MANOIR B, et al. The effects of meperidine and sufentanil on the shivering threshold in postoperative patients [J]. Anesthesiology, 1998, 89: 43-48.
9.	HSIEH M T, CHUEH F Y, LIN M T. Magnolol decreases body temperature by reducing 5hydroxytryptamine release in the rat hypothalamus [J]. Clin Exp Pharmacol Physiol, 1998,25: 813-817.
10.	BHATNAGAR S, SAXENA A, KANNAN T R,et al.Tramadol for postoperative shivering: a doubleblind comparison with pethidine [J]. Anaesth Intensive Care, 2001,29: 149-154.
11.	PIPER S N, MALECK W H, BOLDT J, et al. A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic shivering [J]. Anesth Analg, 2000,90: 954-957.
12.	OWELL R M, BUGGY D J. Ondansetron given before induction of anesthesia reduces shivering after general anesthesia [J]. Anesth Analg, 2000, 90: 1423-1427.
13.	BOCK M, SINNER B, G?TTLICHER M, et al. Involvement of serotonergic pathways in postanaesthetic cold defence: dolasetron prevents shivering [J]. J Thermal Biol, 2002, 27: 159-166.
14.	HORN E P, WERNER C, SESSLER D I, et al. Late intraoperative clonidine administration prevents postanesthetic shivering after total intravenous or volatile anesthesia [J]. Anesth Analg, 1997, 84: 613-617.
15.	PIPER S N, ROHM K D, MALECK W H, et al. Dolasetron for preventing postanesthetic shivering [J]. Anesth Analg, 2002, 94: 106-111.

1. MATHEWS S, AL MULLA A, VARGHESE PK, et al. Postanaesthetic shivering: a new look at tramadol [J]. Anaesthesia, 2002, 57: 394-398.
2. PIPER S N, SUTTNER S W, SCHMIDT C C, et al. Nefopam and clonidine in the prevention of postanaesthetic shivering [J]. Anaesthesia, 1999,54: 695-699.
3. SAGIR O, GULHAS N, TOPRAK H, et al. Control of shivering during regional anaesthesia: prophylactic ketamine and granisetron [J]. Acta Anaesthesiol Scand, 2007,51: 44-49.
4. HORN E P, STANDL T, SESSLER D I, et al. Physostigmine prevents postanesthetic shivering as does meperidine or clonidine [J]. Anesthesiology, 1998,88: 108-113.
5. WANG J J, HO S T, LEE S C, et al. A comparison among nalbuphine, meperidine, and placebo for treating postanesthetic shivering [J]. Anesth Analg, 1999,88: 686-689.
6. IKEDA T, SESSLER D I, TAYEFEH F, et al. Meperidine and alfentanil do not reduce the gain or maximum intensity of shivering [J]. Anesthesiology, 1998,88: 858-865.
7. WRENCH I J, SINGH P, DENNIS A R, et al. The minimum effective doses of pethidine and doxapram in the treatment of postanaesthetic shivering [J]. Anaesthesia, 1997, 52: 32-36.
8. ALFONSI P, SESSLER D I, DU MANOIR B, et al. The effects of meperidine and sufentanil on the shivering threshold in postoperative patients [J]. Anesthesiology, 1998, 89: 43-48.
9. HSIEH M T, CHUEH F Y, LIN M T. Magnolol decreases body temperature by reducing 5hydroxytryptamine release in the rat hypothalamus [J]. Clin Exp Pharmacol Physiol, 1998,25: 813-817.
10. BHATNAGAR S, SAXENA A, KANNAN T R,et al.Tramadol for postoperative shivering: a doubleblind comparison with pethidine [J]. Anaesth Intensive Care, 2001,29: 149-154.
11. PIPER S N, MALECK W H, BOLDT J, et al. A comparison of urapidil, clonidine, meperidine and placebo in preventing postanesthetic shivering [J]. Anesth Analg, 2000,90: 954-957.
12. OWELL R M, BUGGY D J. Ondansetron given before induction of anesthesia reduces shivering after general anesthesia [J]. Anesth Analg, 2000, 90: 1423-1427.
13. BOCK M, SINNER B, G?TTLICHER M, et al. Involvement of serotonergic pathways in postanaesthetic cold defence: dolasetron prevents shivering [J]. J Thermal Biol, 2002, 27: 159-166.
14. HORN E P, WERNER C, SESSLER D I, et al. Late intraoperative clonidine administration prevents postanesthetic shivering after total intravenous or volatile anesthesia [J]. Anesth Analg, 1997, 84: 613-617.
15. PIPER S N, ROHM K D, MALECK W H, et al. Dolasetron for preventing postanesthetic shivering [J]. Anesth Analg, 2002, 94: 106-111.

West China Medical Journal

Efficacy of Granisetron in Preventing Postanesthetic Shivering

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