摘要:目的:建立测定复方氯唑沙宗片中氯唑沙宗血药浓度的方法,并进行其在健康人体药物动力学研究。方法:18名男性健康志愿者单剂量口服复方氯唑沙宗片,高效液相色谱法测定复方氯唑沙宗中氯唑沙宗的血药浓度。结果和结论:此法操作简便、结果可靠。复方氯唑沙宗片中的氯唑沙宗主要药物动力学参数分别为T1/2 （0927±03747） h,Tmax （1403±0681） h,Cmax （21063±5748） mg/L,AUC0~6 （51624±15202） mg/(L·h),AUC0~ （53201±15142） mg/(L·h)。
Abstract: Objective: Aim To investigate the pharmacokinetics of complex chlorzoxazone tablets in healthy volunteers.Methods:Eighteen male healthy subjects received a single dose of two pieces of complex chlorzoxazone tablets.The concentration of complex chlorzoxazone was determined by HPLC.Results and Conclusion: This study provided a simple and reliable assay which can be used to determine two component concentrations of complex chlorzoxazone tablets in human serum. The main pharmacokinetic parameters of chlorzoxazone was as follows:T1/2 （0927±03747）h,Tmax （1403±0681）h,Cmax （21063±5748） mg/L,AUC0~6 （51624±15202） mg/(L·h),AUC0~5 （3201±15142） mg/(L·h).

Citation： LIANG Nan,JIANG Yunping.. Investigation of the Pharmacokinetics of Complex Chlorzoxazone Tablets in Healthy Volunteers. West China Medical Journal, 2009, 24(11): 2921-2923. doi: Copy