• Department of General Surgery, Fuxing Hospital of Capital Medical University, Beijing 100038, China;
LUO Chengyu, Email: luochengyu@163.com
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Objective  To explore the microRNA (miRNA) expression changes and related miRNA characteristics of colorectal cancer (CRC) with hepatic metastasis by miRNA microarray.
Methods  The fresh specimens of primary CRC were collected in 10 patients during operation, which with hepatic metastasis or not. miRNA microarray analysis was performed to compare the miRNA expression levels in two groups. The different expression levels of miRNA were validated by quantitative real-time PCR analysis.
Results  A total of six dysregulated miRNAs were identified in the CRC patients with hepatic metastasis comparing with CRC patients without hepatic metastasis, including 3 up-regulated miRNAs (miR-224, miR-1236, and miR-622) and 3 down-regulated miRNAs (miR-155, miR-342-5p, and miR-363), and the quantitative real-time PCR result of miR-224 consisted with the microarray finding.
Conclusions  miR-224 may be involved in the process of CRC with hepatic metastasis pathogenesis. miR-224 would be a research direction on a new biomarker or therapic method in CRC with hepatic metastasis.

Citation: JI Xiaoxin,YANG Yun,YU Deming,LUO Chengyu. Study on miRNA-224 in Colorectal Cancer with Hepatic Metastasis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(5): 499-502. doi: Copy

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