The Progress of Research on The Relationship Between TRAF6 and Apoptosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Yalin ^1,2 , RUI Yuanyi ^1,2 , LI Yuan ^1,3 ,  ZHOU Zongguang ^1,2

1.Laboratory of Digestive Surgery， West China Hospital， Sichuan University， Chengdu 610041， Sichuan Province， China;;
2.Department of Gastrointestinal Surgery， West China Hospital， Sichuan University，Chengdu 610041， Sichuan Province， China;;
3.Department of Pediatric Surgery， West China Hospital， Sichuan University，Chengdu 610041， Sichuan Province， China;

Corresponding author：

ZHOU Zongguang, Email: zhou767@163.com

Keywords：

Tumor necrosis factor receptor-associated factor 6; Apoptosis; Signaling pathway

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To summarize the relationship between tumor necrosis factor receptor-associated factor 6 （TRAF6） and apoptosis.
Methods 　Domestic and international researches on progress of TRAF6 and apoptotic signaling pathway， especially focused on the functional features of TRAF6 in different system diseases were searched and reviewed.
Results 　TRAF6 took part in several signaling pathways， which had been implicated in regulating apoptosis， and its roles differed in different system diseases and in different conditions. TRAF6 promoted tumorigenesis by inhibiting apoptosis， while it played a proapoptotic or prosurvival role in nervous system and inflammatory diseases.
Conclusion 　TRAF6 plays an important role in apoptosis and involves in the development of tumor， nervous system disease， and inflammatory diseases.

Citation： ZHANG Yalin,RUI Yuanyi,LI Yuan,ZHOU Zongguang,.. The Progress of Research on The Relationship Between TRAF6 and Apoptosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(6): 680-684. doi: Copy

1.	Liu S， Lutz J， Chang J， et al. TRAF6 knockdown promotes survival and inhibits inflammatory response to lipopolysaccharides in rat primary renal proximal tubule cells[J]. Acta Physiol (Oxf)， 2010， 199(3)：339-346.
2.	许国莹，周红. 信号分子TRAF6的研究进展[J]. 细胞与分子免疫学杂志， 2010， 26(12)：1326-1328.
3.	Wu H， Arron JR. TRAF6， a molecular bridge spanning adaptive immunity， innate immunity and osteoimmunology[J]. Bioessays， 2003， 25(11)：1096-1105.
4.	Karin M， Lin A. NF-kappaB at the crossroads of life and death[J]. Nat Immun， 2002， 3(3)：221-227.
5.	Xu LG， Li LY， Shu HB. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis[J]. J Biol Chem， 2004， 279(17)：17278-17282.
6.	Miyahara T， Koyama H， Miyata T， et al. Inflammatory signalingpathway containing TRAF6 contributes to neointimal formation via diverse mechanisms[J]. Cardiovasc Res， 2004， 64(1)：154-164.
7.	Kobayashi T， Walsh PT， Walsh MC， et al. TRAF6 is a critical factor for dendritic cell maturation and development[J]. Immunity，.
8.	Cao Z， Xiong J， Takeuchi M， et al. TRAF6 is a signal transducer for interleukin-1[J]. Nature， 1996， 383(6599)：443-446.
9.	Greene C， O’neill L. Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NF-kappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA[J]. Biochim Biophys Acta， 1999， 1451(1)：109-121.
10.	Matsumura T， Degawa T， Takii T， et al. TRAF6-NF-kappaB pathway is essential for interleukin-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes[J]. Immunology， 2003， 109(1)：127-136.
11.	Kawai T， Akira S. Toll-like receptor downstream signaling[J]. Arthritis Res Ther， 2005， 7(1)：12-19.
12.	Xu J， Wu HF， Ang ES， et al. NF-kappaB modulators in osteolytic bone diseases[J]. Cytokine Growth Factor Rev， 2009， 20(1)：7-17.
13.	Lomaga MA， Henderson JT， Elia AJ， et al. Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS[J]. Neuroscience， 2000， 20(19)：7384-7393.
14.	McCarthy JV， Ni J， Dixit VM. RIP2 is a novel NF-kappa B-activating and cell-death-inducing kinase[J]. J Biol Chem， 1998， 273(27)：16968-16975.
15.	Bertin J， Nir WJ， Fischer CM， et al. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappa B[J]. J Biol Chem， 1999， 274(19)：12955-12958.
16.	He L， Wu X， Siegel R， et al. TRAF6 regulates cell fate decisionsby inducing caspase 8-dependent apoptosis and the activation of NF-kappaB[J]. J Biol Chem， 2006， 281(16)：11235-11249.
17.	Yoon K， Jung EJ， Lee SR， et al. TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3beta[J]. Cell Death Differ， 2008， 15(4)：730-738.
18.	Yoon K， Jung EJ， Lee SY. TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3beta cascade is required for TNF-induced cell survival[J]. Biochem Biophys Res Commun， 2008， 371(1)：118-121.
19.	Liu H， Tamashiro S， Baritaki S， et al. TRAF6 activation in multiple myeloma：a potential therapeutic target[J]. Clin Lymphoma Myeloma Leuk， 2012， 12(3)：155-163.
20.	Chen H， Li M， Campbell RA， et al. Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferationand enhances apoptosis[J]. Oncogene， 2006， 25(49)：6520-6527.
21.	Meng Q， Zheng M， Liu H， et al. TRAF6 regulates proliferation，apoptosis， and invasion of osteosarcoma cell[J]. Mol Cell Biochem， 2012， 371(1-2)：177-186.
22.	Ma T， Wang N， Su Z， et al. Characterization of apoptosis and proliferation in esophageal carcinoma EC109 cells following siRNA-induced down-regulation of TRAF6[J]. Mol Cell Biochem， 2011， 352(1-2)：77-85.
23.	Liu H， Zhang T， Ye J， et al. TNF receptor-associated factor 6 in advanced non-small cell lung cancer：clinical and prognostic impli-cations[J]. J Cancer Res Clin Oncol， 2012， 138(11)：1853-1863.
24.	Jundi M， Nadiri A， Al-Zoobi L， et al. CD40-mediated cell death requires TRAF6 recruitment[J]. Immunobiology， 2012， 217(3)：375-383.
25.	Elmetwali T， Young LS， Palmer DH. CD40 ligand-induced carci-noma cell death：a balance between activation of TNFR-associatedfactor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals[J]. J Immunol， 2010， 184(2)：1111-1120.
26.	Yeiser EC， Rutkoski NJ， Naito A， et al. Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice[J]. Neuroscience， 2004， 24(46)：10521-10529.
27.	Geetha T， Zheng C， Mcgregor WC， et al. TRAF6 and p62 inhibitamyloid β-induced neuronal death through p75 neurotrophin receptor[J]. Neurochem Int， 2012， 61(8)：1289-1293.
28.	Chen J， Wu X， Shao B， et al. Increased expression of TNF receptor-associated factor 6 after rat traumatic brain injury[J]. Cell Mol Neurobiol， 2011， 31(2)：269-275.
29.	Yuan P， Liu Z， Liu M， et al. Up-regulated tumor necrosis factor-associated factor 6 level is correlated with apoptosis in the rat cerebral ischemia and reperfusion[J]. Neurol Sci， 2012. [Epub ahead of print].
30.	Wong F， Hull C， Zhande R， et al. Lipopolysaccharide initiates a TRAF6-mediated endothelial survival signal[J]. Blood， 2004， 103(12)：4520-4526.
31.	Hull C， Mclean G， Wong F， et al. Lipopolysaccharide signals an endothelial apoptosis pathway through TNF receptor-associated factor 6-mediated activation of c-Jun NH2-terminal kinase[J]. J Immunol， 2002， 169(5)：2611-2618.
32.	Bruneau S， Datta D， Flaxenburg JA， et al. TRAF6 inhibits proangiogenic signals in endothelial cells and regulates the expression of vascular endothelial growth factor[J]. Biochem Biophys Res Commun， 2012， 419(1)：66-71.
33.	Zhou X， Li Y， Ding J， et al. Down-regulation of tumor necrosis factor-associated factor 6 is associated with progression of acute pancreatitis complicating lung injury in mice[J]. Tohoku J Exp Med， 2009， 217(4)：279-285.
34.	袁平，周翔宇. TRAF6在机体炎症和免疫应答中作用的研究进展[J]. 现代免疫学， 2010， 30(3)：262-265.
35.	Yang YJ， Chen W， Carrigan SO， et al. TRAF6 specifically contri-butes to FcepsilonRI-mediated cytokine production but not mast cell degranulation[J]. J Biol Chem， 2008， 283(46)：32110-32118.
36.	， 19(3)：353-363.

1. Liu S， Lutz J， Chang J， et al. TRAF6 knockdown promotes survival and inhibits inflammatory response to lipopolysaccharides in rat primary renal proximal tubule cells[J]. Acta Physiol (Oxf)， 2010， 199(3)：339-346.
2. 许国莹，周红. 信号分子TRAF6的研究进展[J]. 细胞与分子免疫学杂志， 2010， 26(12)：1326-1328.
3. Wu H， Arron JR. TRAF6， a molecular bridge spanning adaptive immunity， innate immunity and osteoimmunology[J]. Bioessays， 2003， 25(11)：1096-1105.
4. Karin M， Lin A. NF-kappaB at the crossroads of life and death[J]. Nat Immun， 2002， 3(3)：221-227.
5. Xu LG， Li LY， Shu HB. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis[J]. J Biol Chem， 2004， 279(17)：17278-17282.
6. Miyahara T， Koyama H， Miyata T， et al. Inflammatory signalingpathway containing TRAF6 contributes to neointimal formation via diverse mechanisms[J]. Cardiovasc Res， 2004， 64(1)：154-164.
7. Kobayashi T， Walsh PT， Walsh MC， et al. TRAF6 is a critical factor for dendritic cell maturation and development[J]. Immunity，.
8. Cao Z， Xiong J， Takeuchi M， et al. TRAF6 is a signal transducer for interleukin-1[J]. Nature， 1996， 383(6599)：443-446.
9. Greene C， O’neill L. Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NF-kappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA[J]. Biochim Biophys Acta， 1999， 1451(1)：109-121.
10. Matsumura T， Degawa T， Takii T， et al. TRAF6-NF-kappaB pathway is essential for interleukin-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes[J]. Immunology， 2003， 109(1)：127-136.
11. Kawai T， Akira S. Toll-like receptor downstream signaling[J]. Arthritis Res Ther， 2005， 7(1)：12-19.
12. Xu J， Wu HF， Ang ES， et al. NF-kappaB modulators in osteolytic bone diseases[J]. Cytokine Growth Factor Rev， 2009， 20(1)：7-17.
13. Lomaga MA， Henderson JT， Elia AJ， et al. Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS[J]. Neuroscience， 2000， 20(19)：7384-7393.
14. McCarthy JV， Ni J， Dixit VM. RIP2 is a novel NF-kappa B-activating and cell-death-inducing kinase[J]. J Biol Chem， 1998， 273(27)：16968-16975.
15. Bertin J， Nir WJ， Fischer CM， et al. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappa B[J]. J Biol Chem， 1999， 274(19)：12955-12958.
16. He L， Wu X， Siegel R， et al. TRAF6 regulates cell fate decisionsby inducing caspase 8-dependent apoptosis and the activation of NF-kappaB[J]. J Biol Chem， 2006， 281(16)：11235-11249.
17. Yoon K， Jung EJ， Lee SR， et al. TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3beta[J]. Cell Death Differ， 2008， 15(4)：730-738.
18. Yoon K， Jung EJ， Lee SY. TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3beta cascade is required for TNF-induced cell survival[J]. Biochem Biophys Res Commun， 2008， 371(1)：118-121.
19. Liu H， Tamashiro S， Baritaki S， et al. TRAF6 activation in multiple myeloma：a potential therapeutic target[J]. Clin Lymphoma Myeloma Leuk， 2012， 12(3)：155-163.
20. Chen H， Li M， Campbell RA， et al. Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferationand enhances apoptosis[J]. Oncogene， 2006， 25(49)：6520-6527.
21. Meng Q， Zheng M， Liu H， et al. TRAF6 regulates proliferation，apoptosis， and invasion of osteosarcoma cell[J]. Mol Cell Biochem， 2012， 371(1-2)：177-186.
22. Ma T， Wang N， Su Z， et al. Characterization of apoptosis and proliferation in esophageal carcinoma EC109 cells following siRNA-induced down-regulation of TRAF6[J]. Mol Cell Biochem， 2011， 352(1-2)：77-85.
23. Liu H， Zhang T， Ye J， et al. TNF receptor-associated factor 6 in advanced non-small cell lung cancer：clinical and prognostic impli-cations[J]. J Cancer Res Clin Oncol， 2012， 138(11)：1853-1863.
24. Jundi M， Nadiri A， Al-Zoobi L， et al. CD40-mediated cell death requires TRAF6 recruitment[J]. Immunobiology， 2012， 217(3)：375-383.
25. Elmetwali T， Young LS， Palmer DH. CD40 ligand-induced carci-noma cell death：a balance between activation of TNFR-associatedfactor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals[J]. J Immunol， 2010， 184(2)：1111-1120.
26. Yeiser EC， Rutkoski NJ， Naito A， et al. Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice[J]. Neuroscience， 2004， 24(46)：10521-10529.
27. Geetha T， Zheng C， Mcgregor WC， et al. TRAF6 and p62 inhibitamyloid β-induced neuronal death through p75 neurotrophin receptor[J]. Neurochem Int， 2012， 61(8)：1289-1293.
28. Chen J， Wu X， Shao B， et al. Increased expression of TNF receptor-associated factor 6 after rat traumatic brain injury[J]. Cell Mol Neurobiol， 2011， 31(2)：269-275.
29. Yuan P， Liu Z， Liu M， et al. Up-regulated tumor necrosis factor-associated factor 6 level is correlated with apoptosis in the rat cerebral ischemia and reperfusion[J]. Neurol Sci， 2012. [Epub ahead of print].
30. Wong F， Hull C， Zhande R， et al. Lipopolysaccharide initiates a TRAF6-mediated endothelial survival signal[J]. Blood， 2004， 103(12)：4520-4526.
31. Hull C， Mclean G， Wong F， et al. Lipopolysaccharide signals an endothelial apoptosis pathway through TNF receptor-associated factor 6-mediated activation of c-Jun NH2-terminal kinase[J]. J Immunol， 2002， 169(5)：2611-2618.
32. Bruneau S， Datta D， Flaxenburg JA， et al. TRAF6 inhibits proangiogenic signals in endothelial cells and regulates the expression of vascular endothelial growth factor[J]. Biochem Biophys Res Commun， 2012， 419(1)：66-71.
33. Zhou X， Li Y， Ding J， et al. Down-regulation of tumor necrosis factor-associated factor 6 is associated with progression of acute pancreatitis complicating lung injury in mice[J]. Tohoku J Exp Med， 2009， 217(4)：279-285.
34. 袁平，周翔宇. TRAF6在机体炎症和免疫应答中作用的研究进展[J]. 现代免疫学， 2010， 30(3)：262-265.
35. Yang YJ， Chen W， Carrigan SO， et al. TRAF6 specifically contri-butes to FcepsilonRI-mediated cytokine production but not mast cell degranulation[J]. J Biol Chem， 2008， 283(46)：32110-32118.
36. ， 19(3)：353-363.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Progress of Research on The Relationship Between TRAF6 and Apoptosis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content