PENG Wei 1,2 , YANG Yun 1 , LIU Yunxiao 1,2 , SHU Ye 1
  • 1.Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;;
  • 2.West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China;
SHU Ye, Email: sy999222@yahoo.cn
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Objective  To summarize the relationship between microRNA and the occurrence and progression of colorectal cancer, and to investigate the application value of microRNA in the diagnosis, treatment, and prognosis evaluation of colorectal cancer.
Methods  Domestic and international publications involving the relationship between microRNA and colorectal cancer were retrieved and reviewed.
Results  MicroRNA acted as an oncogene or tumor suppressor gene to participate in cell proliferation, differentiation, apoptosis, metabolism, tumor genesis, and tumor progression. The abnormal expression of microRNA was closely related to the occurrence and progression of colorectal cancer. As specific biomarker, microRNA could be applied in early diagnosis, chemotherapy strategy-making, and prognostic evaluation of colorectal cancer.
Conclusion  MicroRNA is definitely related to the occurrence and progression of colorectal cancer, and it has great prospect in the basic research and clinical applications of colorectal cancer.

Citation: PENG Wei,YANG Yun,LIU Yunxiao,SHU Ye. Advances in The Research and Utilization of MicroRNA in Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(6): 691-686. doi: Copy

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