Pathologic Change Study of Vasa Vasorum in Vessel Wall of Varicose Vein of Lower Extremity_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Guohua , LI Fengchen ,  XU Bing , CHEN Zhinian , WEI Dingxia

Department of Vascular Surgery， Center Hospital of Xinxiang， Xinxiang 453000， Henan Province， China;

Corresponding author：

XU Bing, Email: xubing1968131@163.com

Keywords：

Varicose vein; Vasa vasorum; Vessel remodeling; Density

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To investigate the change of vasa vasorum in vessel wall of varicose vein of the lower extre-mity.
Methods 　Thirty-two patients with varicose vein of the lower extremity were collected， in which of 12 patients with simple varicose veins （varicose group）， 9 patients with recurrent varicose veins （recurrent group）， 11 patients with
thrombophlebitis of varicose vein （thrombophlebitis group）， 9 patients with normal venous tissue as control group. HE staining was performed to observe the distribution of vasa vasorum and detect the vasa vasorum density.
Results 　The increasing vasa vasorums were observed in the adventitia and media， but few was observed in the intima in the varicose， recurrent， and thrombophlebitis groups. The distribution of vasa vasorum was in the adventitia in the control group. The vasa vasorum densities （/mm2） in the varicose， recurrent， and thrombophlebitis groups （5.65±1.45，6.20±
1.73， and 5.94±1.63， respectively） were greater than those in the control group （2.87±0.54）， the difference was
statistically significant （P＜0.05）， but there was no significant difference of the vasa vasorum density among the varicose
vein， recurrent， and thrombophlebitis groups （P＞0.05）.
Conclusion 　Change of vasa vasorum is an important pathol-
gical change with the nosogenis of varicose vein of the lower extremity.

Citation： WANG Guohua,LI Fengchen,XU Bing,CHEN Zhinian,WEI Dingxia,.. Pathologic Change Study of Vasa Vasorum in Vessel Wall of Varicose Vein of Lower Extremity. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(8): 919-921. doi: Copy

1.	Elsharawy MA， Naim MM， Abdelmaguid EM， et al. Role ofsaphenous vein wall in the pathogenesis of primary varicose veins[J]. Interact Cardiovasc Thorac Surg， 2007， 6(2)：219-224.
2.	Haviarova Z， Janega P， Durdik S， et al. Comparison of collagen subtype Ⅰ and Ⅲ presence in varicose and non-varicose vein walls[J]. Bratisl Lek Listy， 2008， 109(3)：102-105.
3.	Witter K， Tonar Z， Matejka VM， et al. Tissue reaction to three different types of tissue glues in an experimental aorta dissection model：a quantitative approach[J]. Histochem Cell Biol， 2010， 133(2)：241-259.
4.	Dockery P， Fraher J. The quantification of vascular beds：a stere-ological approach[J]. Exp Pathol， 2007， 82(2)：110-120.
5.	Tonar Z， Kural T， Kochovác P， et al. Vasa vasorum quantificationin human varicose great and small saphenous veins[J]. Ann Anato， 2012， 194(5)：473-481.
6.	Kachlík D， Lametschwandtner A， Rejmontová J， et al. Vasa vasorum of the human great saphenous vein[J]. Surg Radiol Anat， 2003， 24(6)：377-381.
7.	Kachlik D， Baca V， Stingl J， et al. Architectonic arrangement of the vasa vasorum of the human great saphenous vein[J]. J Vasc Res， 2007， 44(2)：157-166.
8.	褚海波，王国华，王涛，等. 曲张大隐静脉管壁滋养血管分布与定量研究[J/CD]. 中国血管外科杂志：电子版， 2011， 3(1)：25-28.
9.	Kachlík D， Stingl J， Sosna B， et al. Morphological features of vasa vasorum in pathologically changed human great saphenous vein and its tributaries[J]. Vasa， 2008， 37(2)：127-136.
10.	Lengyel I， Acsády G. Histomorphological and pathobiochemical changes of varicose veins. A possible explanation of the development of varicosis[J]. Acta Morphol Hung， 1990， 38(3-4)：259-267.
11.	Prokopová V， Kŏcová J， Horáková M， et al. The structure ofnormal and varicose veins of the lower extremity[J]. Prakt Flebol，.
12.	Kakkos SK， Zolota VG， Peristeropoulou P， et al. Increased mast cell infiltration in familial varicose veins：pathogenetic implications?[J]. Int Angiol， 2003， 22(1)：43-49.
13.	Crotty TP. The roles of turbulence and vasa vasorum in the aetiologyof varicose veins[J]. Med Hypotheses， 1991， 34(1)：41-48.
14.	Riedlová J， Smrzová T. News in the lower extremity veins morp-hology[J]. Rozhl Chir， 2008， 87(10)：549-553.
15.	Bayer IM， Caniggia I， Adamson SL， et al. Experimental angiog-enesis of arterial vasa vasorum[J]. Cell Tissue Res， 2002， 307(3)：303-313.
16.	Mulligan-Kehoe MJ. The vasa vasorum in diseased and nondise-ased arteries[J]. Am J Physiol Heart Circ Physiol， 2010， 298(2)：H295-H305.
17.	Curri BS. The role of vasa vasorum in the genesis of varicose veins[J]. Phlebologie (Paris)， 1992，38-42.
18.	Milroy CM， Scott DJ， Beard JD， et al. Histological appearances of the long saphenous vein[J]. J Pathol， 1989， 159(4)：311-316.
19.	， 7：34-36.

1. Elsharawy MA， Naim MM， Abdelmaguid EM， et al. Role ofsaphenous vein wall in the pathogenesis of primary varicose veins[J]. Interact Cardiovasc Thorac Surg， 2007， 6(2)：219-224.
2. Haviarova Z， Janega P， Durdik S， et al. Comparison of collagen subtype Ⅰ and Ⅲ presence in varicose and non-varicose vein walls[J]. Bratisl Lek Listy， 2008， 109(3)：102-105.
3. Witter K， Tonar Z， Matejka VM， et al. Tissue reaction to three different types of tissue glues in an experimental aorta dissection model：a quantitative approach[J]. Histochem Cell Biol， 2010， 133(2)：241-259.
4. Dockery P， Fraher J. The quantification of vascular beds：a stere-ological approach[J]. Exp Pathol， 2007， 82(2)：110-120.
5. Tonar Z， Kural T， Kochovác P， et al. Vasa vasorum quantificationin human varicose great and small saphenous veins[J]. Ann Anato， 2012， 194(5)：473-481.
6. Kachlík D， Lametschwandtner A， Rejmontová J， et al. Vasa vasorum of the human great saphenous vein[J]. Surg Radiol Anat， 2003， 24(6)：377-381.
7. Kachlik D， Baca V， Stingl J， et al. Architectonic arrangement of the vasa vasorum of the human great saphenous vein[J]. J Vasc Res， 2007， 44(2)：157-166.
8. 褚海波，王国华，王涛，等. 曲张大隐静脉管壁滋养血管分布与定量研究[J/CD]. 中国血管外科杂志：电子版， 2011， 3(1)：25-28.
9. Kachlík D， Stingl J， Sosna B， et al. Morphological features of vasa vasorum in pathologically changed human great saphenous vein and its tributaries[J]. Vasa， 2008， 37(2)：127-136.
10. Lengyel I， Acsády G. Histomorphological and pathobiochemical changes of varicose veins. A possible explanation of the development of varicosis[J]. Acta Morphol Hung， 1990， 38(3-4)：259-267.
11. Prokopová V， Kŏcová J， Horáková M， et al. The structure ofnormal and varicose veins of the lower extremity[J]. Prakt Flebol，.
12. Kakkos SK， Zolota VG， Peristeropoulou P， et al. Increased mast cell infiltration in familial varicose veins：pathogenetic implications?[J]. Int Angiol， 2003， 22(1)：43-49.
13. Crotty TP. The roles of turbulence and vasa vasorum in the aetiologyof varicose veins[J]. Med Hypotheses， 1991， 34(1)：41-48.
14. Riedlová J， Smrzová T. News in the lower extremity veins morp-hology[J]. Rozhl Chir， 2008， 87(10)：549-553.
15. Bayer IM， Caniggia I， Adamson SL， et al. Experimental angiog-enesis of arterial vasa vasorum[J]. Cell Tissue Res， 2002， 307(3)：303-313.
16. Mulligan-Kehoe MJ. The vasa vasorum in diseased and nondise-ased arteries[J]. Am J Physiol Heart Circ Physiol， 2010， 298(2)：H295-H305.
17. Curri BS. The role of vasa vasorum in the genesis of varicose veins[J]. Phlebologie (Paris)， 1992，38-42.
18. Milroy CM， Scott DJ， Beard JD， et al. Histological appearances of the long saphenous vein[J]. J Pathol， 1989， 159(4)：311-316.
19. ， 7：34-36.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Pathologic Change Study of Vasa Vasorum in Vessel Wall of Varicose Vein of Lower Extremity

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