Analysis on Change of Constitution in Thyroid Diseases of West China Hospital Between 2000 and 2012_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

OU Xiuhe , SUN Yinghe , ZHU Xinxin , HUANG Qiushi , LI Zhihui , GONG Rixiang , GOU Juxiang , LIU Feng , DU Zhenhong ,  ZHU Jingqiang

Department of Thyroid and Breast Surgery， West China Hospital， Sichuan University， Chengdu 610041， Sichuan Province， China;

Corresponding author：

ZHU Jingqiang, Email: zjq-wkys@163.com

Keywords：

Thyroid disease; Thyroid carcinoma; Ratio; Change

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Objective 　To explore the change of constitution in thyroid diseases of West China Hospital between 2000 and 2012， in order to provide clinical evidence.
Methods 　Clinical data， including gender， age， and pathological diagnosis of patients with thyroid disease who underwent primary thyroid surgery in our hospital from 2000 to 2012 were collected retrospectively and analyzed statistically.
Results 　A total of 9 642 patients were enrolled， including 1 893 male patients and 7 749 female patients. The ratio of male to female patients was 1 to 4.09. In male patients， the proportion of thyroid carcinoma were significantly higher than those of female group （P=0.02）；in male patients younger than 45 group， the proportion of thyroid carcinoma were significantly higher than those of female group （P＜0.01）. There was no statistical difference on the proportion between male and female patients older than 45 group （P=0.90）. Proportion of thyroid carcinoma， especially proportion of papillary thyroid carcinoma （PTC） increased in general. Proportion of Hashimoto thyroiditis （HT） increased in general too. HT with thyroid carcinoma accounted for an increasing proportion of all patients with HT. Proportion of nodular goiter （NG） increased at first and then declined. Proportion of thyroid adenoma （TA） decreased on the whole.
Conclusions 　Proportion of thyroid carcinoma， especially proportion of PTC increase in recent years on the whole in patients underwent surgery. All these changes need to be given sufficient attention.

Citation： OU Xiuhe,SUN Yinghe,ZHU Xinxin,HUANG Qiushi,LI Zhihui,GONG Rixiang,GOU Juxiang,LIU Feng,DU Zhenhong,ZHU Jingqiang,.. Analysis on Change of Constitution in Thyroid Diseases of West China Hospital Between 2000 and 2012. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(9): 987-991. doi: Copy

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4.	钱碧云，何敏，陈可欣，等. 天津城市居民甲状腺乳头状癌发病率和构成比的长期时间趋势分析[J]. 中国实用外科杂志， 2011， 31(5)：420-422.
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8.	Lee TI， Yang HJ， Lin SY， et al. The accuracy of fine-needleaspiration biopsy and frozen section in patients with thyroid cancer[J]. Thyroid， 2002， 12(7)：619-626.
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17.	Li Y， Nishihara E， Kakudo K. Hashimoto’s thyroiditis：old concepts and new insights[J]. Curr Opin Rheumatol， 2011， 23(1)：102-107.
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21.	Mazokopakis EE， Tzortzinis AA， Dalieraki-Ott EI， et al. Coex-istence of Hashimoto’s thyroiditis with papillary thyroid carcinoma.A retrospective study[J]. Hormones (Athens)， 2010， 9(4)：312-317.
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23.	邵自功，易德会，钟鑫平，等. 慢性淋巴细胞性甲状腺炎合并甲状腺癌104例临床分析[J]. 中国医科大学学报， 2011， 40(12)：1137-1139.
24.	Hyjek E， Isaacson PG. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto’s thyroiditis[J]. Hum Pathol， 1988， 19(11)：1315-1326.
25.	Derringer GA， Thompson LD， Frommelt RA， et al. Malignant lymphoma of the thyroid gland：a clinicopathologic study of 108 cases[J]. Am J Surg Pathol， 2000， 24(5)：623-639.
26.	Kim NR， Ko YH， Lee YD. Primary T-cell lymphoma of thethyroid associated with Hashimoto’s thyroiditis， histologically mimicking MALT-lymphoma[J]. J Korean Med Sci， 2010， 25(3)：481-484.
27.	Di Pasquale M， Rothstein JL， Palazzo JP. Pathologic features of Hashimoto’s-associated papillary thyroid carcinomas[J]. Hum Pathol， 2001， 32(1)：24-30.
28.	Prasad ML， Huang Y， Pellegata NS， et al. Hashimoto’s thyroiditiswith papillary thyroid carcinoma (PTC)-like nuclear alterations express molecular markers of PTC[J]. Histopathology， 2004， 45(1)：39-46.
29.	Unger P， Ewart M， Wang BY， et al. Expression of p63 in papillarythyroid carcinoma and in Hashimoto’s thyroiditis：a pathobiologic link?[J]. Hum Pathol， 2003， 34(8)：764-769.
30.	Fiore E， Rago T， Latrofa F， et al. Hashimoto’s thyroiditis is associated with papillary thyroid carcinoma：role of TSH and of treatment with L-thyroxine[J]. Endocr Relat Cancer， 2011， 18(4)：429-437.
31.	Paulson LM， Shindo ML， Schuff KG. Role of chronic lymphocytic thyroiditis in central node metastasis of papillary thyroid carcinoma[J]. Otolaryngol Head Neck Surg， 2012， 147(3)：444-449.
32.	Yoon YH， Kim HJ， Lee JW， et al. The clinicopathologic differences in papillary thyroid carcinoma with or without coexisting chronic lymphocytic thyroiditis[J]. Eur Arch Otorhinolaryngol， 2012， 269(3)：1013-1017.
33.	， 33(5 Suppl)：51-56.

1. Sherman SI. Thyroid carcinoma[J]. Lancet， 2003， 361(9356)：501-511.
2. Schlumberger MJ. Papillary and follicular thyroid carcinoma[J]. N Engl J Med， 1998， 338(5)：297-306.
3. Simard EP， Ward EM， Siegel R， et al. Cancers with increasing incidence trends in the United States：1999 through 2008[J]. CA Cancer J Clin， 2012， 62(2)：118-128.
4. 钱碧云，何敏，陈可欣，等. 天津城市居民甲状腺乳头状癌发病率和构成比的长期时间趋势分析[J]. 中国实用外科杂志， 2011， 31(5)：420-422.
5. 王冬飞，李毅本. 杭州市萧山区1988年至2009年甲状腺癌发病分析[J]. 中华内分泌代谢杂志， 2010， 26(10)：843-846.
6. 牛丽娟，郝玉芝，周纯武. 超声诊断甲状腺占位性病变的价值[J]. 中华耳鼻咽喉头颈外科杂志， 2006， 41(6)：415-418.
7. 张广，边学海，张纯海，等. 超声引导下粗针组织活检对甲状腺结节诊断的意义[J]. 中国普外基础与临床杂志， 2011， 18(8)：815-818.
8. Lee TI， Yang HJ， Lin SY， et al. The accuracy of fine-needleaspiration biopsy and frozen section in patients with thyroid cancer[J]. Thyroid， 2002， 12(7)：619-626.
9. Davies L， Welch HG. Increasing incidence of thyroid cancer in the United States， 1973-2002[J]. JAMA， 2006， 295(18)：2164-2167.
10. 赵留芳，李晓江，任艳鑫，等. 2 539例甲状腺疾病构成分析[J]. 中国病案， 2012， 13(11)：77-79.
11. 000例病理构成[J]. 广东医学， 2011， 32(12)：1564-1566.
12. 庞飞雄，张嘉越，冷津立，等. 1991～2010年甲状腺术后.
13. 王云龙，巩鹏. 甲状腺癌构成比变化分析[J]. 大连医科大学学报， 2010， 32(5)：558-561.
14. Gharib H， Papini E， Paschke R， et al. American Association of Clinical Endocrinologists， Associazione Medici Endocrinologi， and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules：executive summary of recommendations[J]. J Endocrinol Invest，.
15. Cooper DS， Doherty GM， Haugen BR， et al. Revised Americanthyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer[J]. Thyroid， 2009， 19(11)：1167-1214.
16. 朱精强. 甲状腺结节的非手术治疗[J]. 中国普外基础与临床杂志， 2011， 18(8)：794-795.
17. Li Y， Nishihara E， Kakudo K. Hashimoto’s thyroiditis：old concepts and new insights[J]. Curr Opin Rheumatol， 2011， 23(1)：102-107.
18. Costanzo M， Caruso LA， Testa R， et al. Hashimoto thyroiditis. Possible cause or consequence of a malignant thyroid tumor[J]. Ann Ital Chir， 2006， 77(6)：469-471.
19. Anil C， Goksel S， Gursoy A. Hashimoto’s thyroiditis is not asso-ciated with increased risk of thyroid cancer in patients with thyroidnodules：a single-center prospective study[J]. Thyroid， 2010， 20(6)：601-606.
20. Gul K， Dirikoc A， Kiyak G， et al. The association between thyroid carcinoma and Hashimoto’s thyroiditis：the ultrasonographic and histopathologic characteristics of malignant nodules[J]. Thyroid， 2010， 20(8)：873-878.
21. Mazokopakis EE， Tzortzinis AA， Dalieraki-Ott EI， et al. Coex-istence of Hashimoto’s thyroiditis with papillary thyroid carcinoma.A retrospective study[J]. Hormones (Athens)， 2010， 9(4)：312-317.
22. 李鸿涛，任光辉，董朝，等. 桥本氏甲状腺炎合并甲状腺癌54例临床研究[J]. 中南大学学报：医学版， 2011， 36(8)：765-767.
23. 邵自功，易德会，钟鑫平，等. 慢性淋巴细胞性甲状腺炎合并甲状腺癌104例临床分析[J]. 中国医科大学学报， 2011， 40(12)：1137-1139.
24. Hyjek E， Isaacson PG. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto’s thyroiditis[J]. Hum Pathol， 1988， 19(11)：1315-1326.
25. Derringer GA， Thompson LD， Frommelt RA， et al. Malignant lymphoma of the thyroid gland：a clinicopathologic study of 108 cases[J]. Am J Surg Pathol， 2000， 24(5)：623-639.
26. Kim NR， Ko YH， Lee YD. Primary T-cell lymphoma of thethyroid associated with Hashimoto’s thyroiditis， histologically mimicking MALT-lymphoma[J]. J Korean Med Sci， 2010， 25(3)：481-484.
27. Di Pasquale M， Rothstein JL， Palazzo JP. Pathologic features of Hashimoto’s-associated papillary thyroid carcinomas[J]. Hum Pathol， 2001， 32(1)：24-30.
28. Prasad ML， Huang Y， Pellegata NS， et al. Hashimoto’s thyroiditiswith papillary thyroid carcinoma (PTC)-like nuclear alterations express molecular markers of PTC[J]. Histopathology， 2004， 45(1)：39-46.
29. Unger P， Ewart M， Wang BY， et al. Expression of p63 in papillarythyroid carcinoma and in Hashimoto’s thyroiditis：a pathobiologic link?[J]. Hum Pathol， 2003， 34(8)：764-769.
30. Fiore E， Rago T， Latrofa F， et al. Hashimoto’s thyroiditis is associated with papillary thyroid carcinoma：role of TSH and of treatment with L-thyroxine[J]. Endocr Relat Cancer， 2011， 18(4)：429-437.
31. Paulson LM， Shindo ML， Schuff KG. Role of chronic lymphocytic thyroiditis in central node metastasis of papillary thyroid carcinoma[J]. Otolaryngol Head Neck Surg， 2012， 147(3)：444-449.
32. Yoon YH， Kim HJ， Lee JW， et al. The clinicopathologic differences in papillary thyroid carcinoma with or without coexisting chronic lymphocytic thyroiditis[J]. Eur Arch Otorhinolaryngol， 2012， 269(3)：1013-1017.
33. ， 33(5 Suppl)：51-56.

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Analysis on Change of Constitution in Thyroid Diseases of West China Hospital Between 2000 and 2012

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