Advances in Research of MicroRNA in The Pathogenesis of Type 2 Diabetes_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SUN Lei ,  WANG Yong , YANG Jian

Department of Biliary， Herniary， and Obesity Surgery， Shengjing Hospital of China Medical University， Shenyang110004， Liaoning Province， China;

Corresponding author：

WANG Yong, Email: wangy@sj-hospital.org

Keywords：

MicroRNA; Type 2 diabetes; Complication; Insulin secretion; Insulin resistance; Obesity

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To summarize the relationship of diabetes and its complications with microRNA.
Methods 　Domestic and international researches were collected by searching to summarize the role of microRNA in diabetes and its complications.
Results 　MicroRNA could affect the secretion of insulin and interfer metabolism of gulcose in fat cells， muscle cells， and liver cells， which resulting in insulin resistance. At the same time， the microRNA also played an role in damage of vascular endothelial cells and myocardial cell in diabetes.
Conclusion 　MicroRNA acts an important role in the process of diabetes and its complications.

Citation： SUN Lei,WANG Yong,YANG Jian,.. Advances in Research of MicroRNA in The Pathogenesis of Type 2 Diabetes. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(9): 1069-1074. doi: Copy

1.	Siomi H， Siomi MC. Posttranscriptional regulation of microRNA biogenesis in animals[J]. Mol Cell， 2010， 38(3)：323-332.
2.	Cifuentes D， Xue H， Taylor DW， et al. A novel miRNA processingpathway independent of Dicer requires Argonaute2 catalytic activity[J]. Science， 2010， 328(5986)：1694-1698.
3.	Ruby JG， Jan CH， Bartel DP. Intronic microRNA precursors that bypass drosha processing[J]. Nature， 2007， 448(7149)：83-86.
4.	Friedman RC， Farh KK， Burge CB， et al. Most mammalian mRNAs are conserved targets of microRNAs[J]. Genome Res， 2009， 19(1)：92-105.
5.	Djuranovic S， Nahvi A， Green R. A parsimonious model for gene regulation by miRNAs[J]. Science， 2011， 331(6017)：550-553.
6.	Karolina DS， Armugam A， Tavintharan S， et al. MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus[J]. PLoS One， 2011， 6(8)：e22839.
7.	Herrera BM， Lockstone HE， Taylor JM， et al. Global microRNAexpression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes[J]. Diabetologia， 2010， 53(6)：1099-1109.
8.	Balasubramanyam M， Aravind S， Gokulakrishnan K， et al. Imp-aired miR-146a expression links subclinical inflammation andinsulin resistance in type 2 diabetes[J]. Mol Cell Biochem， 2011，.
9.	Kong L， Zhu J， Han W， et al. Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes：a clinical study[J]. Acta Diabetol， 2011， 48(1)：61-69.
10.	Suppl 2：67-73.
11.	McArthur K， Feng B， Wu Y， et al. MicroRNA-200b regulates vascular endothelial growth factor-mediated alterations in diabetic retinopathy[J]. Diabetes， 2011， 60(4)：1314-1323.
12.	Feng B， Chen S， McArthur K， et al. MiR-146a-mediated extrace-llular matrix protein production in chronic diabetes complications[J]. Diabetes， 2011， 60(11)：2975-2984.
13.	Schalkwijk CG， Stehouwer CD. Vascular complications in diab-etes mellitus：the role of endothelial dysfunction[J]. Clin Sci (Lond)， 2005， 109(2)：143-159.
14.	Chen S， Apostolova MD， Cherian MG， et al. Interaction of endothelin-1 with vasoactive factors in mediating glucose-induced increased permeability in endothelial cells[J]. Lab Invest， 2000，.
15.	Correa-Medina M， Bravo-Egana V， Rosero S， et al. MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas[J]. Gene Expr， 2009， 9(4)：193-199.
16.	Bravo-Egana V， Rosero S， Molano RD， et al. Quantitative differ-ential expression analysis reveals miR-7 as major islet microRNA[J]. Biochem Biophys Res Commun， 2008， 366(4)：922-926.
17.	El Ouaamari A， Baroukh N， Martens GA， et al. MiR-375 targets 3’-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells[J]. Diabetes， 2008， 57(10)：2708-2717.
18.	Avnit-Sagi T， Vana T， Walker MD. Transcriptional mechanisms controlling miR-375 gene expression in the pancreas[J]. Exp Diabetes Res， 2012， 2012：891216.
19.	Zhao X， Mohan R， Özcan S， et al. MicroRNA-30d inducesinsulin transcription factor MafA and insulin production by targetingmitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells[J]. J Biol Chem， 2012， 287(37)：31155-31164.
20.	Ramachandran D， Roy U， Garg S， et al. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets[J]. FEBS J， 2011， 278(7)：1167-1174.
21.	Ryu HS， Park SY， Ma D， et al. The induction of microRNA targ-eting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes[J]. PLoS One， 2011， 6(3)：e17343.
22.	Jordan SD， Krüger M， Willmes DM， et al. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism[J]. Nat Cell Biol， 2011， 13(4)：434-446.
23.	Zhou B， Li C， Qi W， et al. Downregulation of miR-181a upreg-ulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity[J]. Diabetologia， 2012， 55(7)：2032-2043.
24.	Li Y， Xu S， Giles A， et al. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver[J]. FASEB J， 2011， 25(5)：1664-1679.
25.	Poy MN， Spranger M， Stoffel M. MicroRNAs and the regulationof glucose and lipid metabolism[J]. Diabetes Obes Metab， 2007，.
26.	Lu H， Buchan RJ， Cook SA. MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism[J]. Cardiovasc Res， 2010， 86(3)：410-420.
27.	Huang B， Qin W， Zhao B， et al. MicroRNA expression profiling in diabetic GK rat model[J]. Acta Biochim Biophys Sin (Shanghai)， 2009， 41(6)：472-477.
28.	Keren A， Tamir Y， Bengal E. The p38 MAPK signaling pathway：a major regulator of skeletal muscle development[J]. Mol Cell Endocrinol， 2006， 252(1-2)：224-230.
29.	Guo C， Sah JF， Beard L， et al. The noncoding RNA， miR-126， suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers[J]. Genes Chromosomes Cancer， 2008， 47(11)：939-946.
30.	Yki-Järvinen H. Glucose toxicity[J]. Endocr Rev， 1992， 13(3)：.
31.	Sun LL， Jiang BG， Li WT， et al. MicroRNA-15a positively regul-ates insulin synthesis by inhibiting uncoupling protein-2 expression[J]. Diabetes Res Clin Pract， 2011， 91(1)：94-100.
32.	Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM[J]. Diabetes， 1997， 46(1)：3-10.
33.	Ortega FJ， Moreno-Navarrete JM， Pardo G， et al. MiRNA expre-ssion profile of human subcutaneous adipose and during adipocyte differentiation[J]. PLoS One， 2010， 5(2)：e9022.
34.	Ling HY， Wen GB， Feng SD， et al. MicroRNA-375 promotes 3T3-L1 adipocyte differentiation through modulation of extracellular signal-regulated kinase signalling[J]. Clin Exp Pharmacol Physiol， 2011， 38(4)：239-246.
35.	Farmer SR. Transcriptional control of adipocyte formation[J]. Cell Metab， 2006， 4(4)：263-273.
36.	Kim YJ， Hwang SH， Cho HH， et al. MicroRNA 21 regulates the proliferation of human adipose tissue-derived mesenchymal stem cells and high-fat diet-induced obesity alters microRNA 21 expression in white adipose tissues[J]. J Cell Physiol， 2012， 227(1)：183-193.
37.	Karbiener M， Neuhold C， Opriessnig P， et al. MicroRNA-30c promotes human adipocyte differentiation and co-represses PAI-1 and ALK2[J]. RNA Biol， 2011， 8(5)：850-860.
38.	Trajkovski M， Hausser J， Soutschek J， et al. MicroRNAs 103 and 107 regulate insulin sensitivity[J]. Nature， 2011， 474(7353)：649-653.
39.	Ling HY， Hu B， Hu XB， et al. MiRNA-21 reverses high glucose and high insulin induced insulin resistance in 3T3-L1 adipocytes through targeting phosphatase and tensin homologue[J]. Exp Clin Endocrinol Diabetes， 2012， 120(9)：553-559.
40.	Shen E， Diao X， Wang X， et al. MicroRNAs involved in themitogen-activated protein kinase cascades pathway during glucose-induced cardiomyocyte hypertrophy[J]. Am J Pathol， 2011， 179(2)：639-650.
41.	Feng B， Chen S， George B， et al. MiR133a regulates cardiomyocyte hypertrophy in diabetes[J]. Diabetes Metab Res Rev， 2010， 26(1)：40-49.
42.	Shan ZX， Lin QX， Deng CY， et al. MiR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes[J]. FEBS Lett， 2010， 584(16)：3592-3600.
43.	Xie S， Xie N， Li Y， et al. Upregulation of TRB2 induced by miR-98 in the early lesions of large artery of type-2 diabetic rat[J]. Mol Cell Biochem， 2012， 361(1-2)：305-314.
44.	Feng B， Chakrabarti S. MiR-320 regulates glucose-induced gene expression in diabetes[J]. ISRN Endocrinol， 2012， 2012：549875.
45.	Long J， Wang Y， Wang W， et al. MicroRNA-29c is a signature microRNA under high glucose conditions that targets Sprouty homolog 1， and its in vivo knockdown prevents progression of diabetic nephropathy[J]. J Biol Chem， 2011， 286(13)：11837-11848.
46.	Kato M， Zhang J， Wang M， et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors[J]. Proc Natl Acad Sci U S A， 2007， 104(9)：3432-3437.
47.	Krupa A， Jenkins R， Luo DD， et al. Loss of microRNA-192 promotes fibrogenesis in diabetic nephropathy[J]. J Am Soc Nephrol， 2010， 21(3)：438-447.
48.	Qian Y， Feldman E， Pennathur S， et al. From fibrosis to sclerosis：mechanisms of glomerulosclerosis in diabetic nephropathy[J]. Diabetes， 2008， 57(6)：1439-1445.
49.	Fu Y， Zhang Y， Wang Z， et al. Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy[J]. J Nephrol， 2010， 32(6)：581-589.
50.	Chen X， Ba Y， Ma L， et al. Characterization of microRNAs in serum：a novel class of biomarkers for diagnosis of cancer and other diseases[J]. Cell Res， 2008， 18(10)：997-1006.
51.	(8)：1311-1321.
52.	(1-2)：197-205.
53.	-431.

1. Siomi H， Siomi MC. Posttranscriptional regulation of microRNA biogenesis in animals[J]. Mol Cell， 2010， 38(3)：323-332.
2. Cifuentes D， Xue H， Taylor DW， et al. A novel miRNA processingpathway independent of Dicer requires Argonaute2 catalytic activity[J]. Science， 2010， 328(5986)：1694-1698.
3. Ruby JG， Jan CH， Bartel DP. Intronic microRNA precursors that bypass drosha processing[J]. Nature， 2007， 448(7149)：83-86.
4. Friedman RC， Farh KK， Burge CB， et al. Most mammalian mRNAs are conserved targets of microRNAs[J]. Genome Res， 2009， 19(1)：92-105.
5. Djuranovic S， Nahvi A， Green R. A parsimonious model for gene regulation by miRNAs[J]. Science， 2011， 331(6017)：550-553.
6. Karolina DS， Armugam A， Tavintharan S， et al. MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus[J]. PLoS One， 2011， 6(8)：e22839.
7. Herrera BM， Lockstone HE， Taylor JM， et al. Global microRNAexpression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes[J]. Diabetologia， 2010， 53(6)：1099-1109.
8. Balasubramanyam M， Aravind S， Gokulakrishnan K， et al. Imp-aired miR-146a expression links subclinical inflammation andinsulin resistance in type 2 diabetes[J]. Mol Cell Biochem， 2011，.
9. Kong L， Zhu J， Han W， et al. Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes：a clinical study[J]. Acta Diabetol， 2011， 48(1)：61-69.
10. Suppl 2：67-73.
11. McArthur K， Feng B， Wu Y， et al. MicroRNA-200b regulates vascular endothelial growth factor-mediated alterations in diabetic retinopathy[J]. Diabetes， 2011， 60(4)：1314-1323.
12. Feng B， Chen S， McArthur K， et al. MiR-146a-mediated extrace-llular matrix protein production in chronic diabetes complications[J]. Diabetes， 2011， 60(11)：2975-2984.
13. Schalkwijk CG， Stehouwer CD. Vascular complications in diab-etes mellitus：the role of endothelial dysfunction[J]. Clin Sci (Lond)， 2005， 109(2)：143-159.
14. Chen S， Apostolova MD， Cherian MG， et al. Interaction of endothelin-1 with vasoactive factors in mediating glucose-induced increased permeability in endothelial cells[J]. Lab Invest， 2000，.
15. Correa-Medina M， Bravo-Egana V， Rosero S， et al. MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas[J]. Gene Expr， 2009， 9(4)：193-199.
16. Bravo-Egana V， Rosero S， Molano RD， et al. Quantitative differ-ential expression analysis reveals miR-7 as major islet microRNA[J]. Biochem Biophys Res Commun， 2008， 366(4)：922-926.
17. El Ouaamari A， Baroukh N， Martens GA， et al. MiR-375 targets 3’-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells[J]. Diabetes， 2008， 57(10)：2708-2717.
18. Avnit-Sagi T， Vana T， Walker MD. Transcriptional mechanisms controlling miR-375 gene expression in the pancreas[J]. Exp Diabetes Res， 2012， 2012：891216.
19. Zhao X， Mohan R， Özcan S， et al. MicroRNA-30d inducesinsulin transcription factor MafA and insulin production by targetingmitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells[J]. J Biol Chem， 2012， 287(37)：31155-31164.
20. Ramachandran D， Roy U， Garg S， et al. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets[J]. FEBS J， 2011， 278(7)：1167-1174.
21. Ryu HS， Park SY， Ma D， et al. The induction of microRNA targ-eting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes[J]. PLoS One， 2011， 6(3)：e17343.
22. Jordan SD， Krüger M， Willmes DM， et al. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism[J]. Nat Cell Biol， 2011， 13(4)：434-446.
23. Zhou B， Li C， Qi W， et al. Downregulation of miR-181a upreg-ulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity[J]. Diabetologia， 2012， 55(7)：2032-2043.
24. Li Y， Xu S， Giles A， et al. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver[J]. FASEB J， 2011， 25(5)：1664-1679.
25. Poy MN， Spranger M， Stoffel M. MicroRNAs and the regulationof glucose and lipid metabolism[J]. Diabetes Obes Metab， 2007，.
26. Lu H， Buchan RJ， Cook SA. MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism[J]. Cardiovasc Res， 2010， 86(3)：410-420.
27. Huang B， Qin W， Zhao B， et al. MicroRNA expression profiling in diabetic GK rat model[J]. Acta Biochim Biophys Sin (Shanghai)， 2009， 41(6)：472-477.
28. Keren A， Tamir Y， Bengal E. The p38 MAPK signaling pathway：a major regulator of skeletal muscle development[J]. Mol Cell Endocrinol， 2006， 252(1-2)：224-230.
29. Guo C， Sah JF， Beard L， et al. The noncoding RNA， miR-126， suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers[J]. Genes Chromosomes Cancer， 2008， 47(11)：939-946.
30. Yki-Järvinen H. Glucose toxicity[J]. Endocr Rev， 1992， 13(3)：.
31. Sun LL， Jiang BG， Li WT， et al. MicroRNA-15a positively regul-ates insulin synthesis by inhibiting uncoupling protein-2 expression[J]. Diabetes Res Clin Pract， 2011， 91(1)：94-100.
32. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM[J]. Diabetes， 1997， 46(1)：3-10.
33. Ortega FJ， Moreno-Navarrete JM， Pardo G， et al. MiRNA expre-ssion profile of human subcutaneous adipose and during adipocyte differentiation[J]. PLoS One， 2010， 5(2)：e9022.
34. Ling HY， Wen GB， Feng SD， et al. MicroRNA-375 promotes 3T3-L1 adipocyte differentiation through modulation of extracellular signal-regulated kinase signalling[J]. Clin Exp Pharmacol Physiol， 2011， 38(4)：239-246.
35. Farmer SR. Transcriptional control of adipocyte formation[J]. Cell Metab， 2006， 4(4)：263-273.
36. Kim YJ， Hwang SH， Cho HH， et al. MicroRNA 21 regulates the proliferation of human adipose tissue-derived mesenchymal stem cells and high-fat diet-induced obesity alters microRNA 21 expression in white adipose tissues[J]. J Cell Physiol， 2012， 227(1)：183-193.
37. Karbiener M， Neuhold C， Opriessnig P， et al. MicroRNA-30c promotes human adipocyte differentiation and co-represses PAI-1 and ALK2[J]. RNA Biol， 2011， 8(5)：850-860.
38. Trajkovski M， Hausser J， Soutschek J， et al. MicroRNAs 103 and 107 regulate insulin sensitivity[J]. Nature， 2011， 474(7353)：649-653.
39. Ling HY， Hu B， Hu XB， et al. MiRNA-21 reverses high glucose and high insulin induced insulin resistance in 3T3-L1 adipocytes through targeting phosphatase and tensin homologue[J]. Exp Clin Endocrinol Diabetes， 2012， 120(9)：553-559.
40. Shen E， Diao X， Wang X， et al. MicroRNAs involved in themitogen-activated protein kinase cascades pathway during glucose-induced cardiomyocyte hypertrophy[J]. Am J Pathol， 2011， 179(2)：639-650.
41. Feng B， Chen S， George B， et al. MiR133a regulates cardiomyocyte hypertrophy in diabetes[J]. Diabetes Metab Res Rev， 2010， 26(1)：40-49.
42. Shan ZX， Lin QX， Deng CY， et al. MiR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes[J]. FEBS Lett， 2010， 584(16)：3592-3600.
43. Xie S， Xie N， Li Y， et al. Upregulation of TRB2 induced by miR-98 in the early lesions of large artery of type-2 diabetic rat[J]. Mol Cell Biochem， 2012， 361(1-2)：305-314.
44. Feng B， Chakrabarti S. MiR-320 regulates glucose-induced gene expression in diabetes[J]. ISRN Endocrinol， 2012， 2012：549875.
45. Long J， Wang Y， Wang W， et al. MicroRNA-29c is a signature microRNA under high glucose conditions that targets Sprouty homolog 1， and its in vivo knockdown prevents progression of diabetic nephropathy[J]. J Biol Chem， 2011， 286(13)：11837-11848.
46. Kato M， Zhang J， Wang M， et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors[J]. Proc Natl Acad Sci U S A， 2007， 104(9)：3432-3437.
47. Krupa A， Jenkins R， Luo DD， et al. Loss of microRNA-192 promotes fibrogenesis in diabetic nephropathy[J]. J Am Soc Nephrol， 2010， 21(3)：438-447.
48. Qian Y， Feldman E， Pennathur S， et al. From fibrosis to sclerosis：mechanisms of glomerulosclerosis in diabetic nephropathy[J]. Diabetes， 2008， 57(6)：1439-1445.
49. Fu Y， Zhang Y， Wang Z， et al. Regulation of NADPH oxidase activity is associated with miRNA-25-mediated NOX4 expression in experimental diabetic nephropathy[J]. J Nephrol， 2010， 32(6)：581-589.
50. Chen X， Ba Y， Ma L， et al. Characterization of microRNAs in serum：a novel class of biomarkers for diagnosis of cancer and other diseases[J]. Cell Res， 2008， 18(10)：997-1006.
51. (8)：1311-1321.
52. (1-2)：197-205.
53. -431.

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Advances in Research of MicroRNA in The Pathogenesis of Type 2 Diabetes

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