IgG4 Related Thyroid Diseases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Xunli , HUANG Qiushi , ZHU Xinxin , DU Zhenhong , CHEN Qiang , DENG Qiaolian , SUN Yinghe , CHEN Rui , WEI Tao , LIU Feng , MA Yu , GONG Rixiang , LI Zhihui ,  ZHU Jingqiang

Department of Thyroid and Breast Surgery， West China Hospital， Sichuan University， Chengdu 610041， Sichuan Province， China;

Corresponding author：

ZHU Jingqiang, Email: zjq-wkys@163.com

Keywords：

IgG4-related thyroid disease; IgG4; Hashimoto thyroiditis; Riedel thyroiditis; Papillary thyroid carcinoma

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Abstract Full text Figures/Tables Video References Cited by

Objective 　To summarize the relationship between IgG4 and IgG4 related thyroid diseases.
Methods 　Domestic and international publications involving the pathological features of IgG4-related thyroid diseases and relationship with IgG4 were retrieved and reviewed.
Results 　IgG4-related disease was a newly recognized class of chronic and systemic lymphocytes disease， which may be solitary or involving multiple body organs， as well as thyroid. The expression of IgG4 was found in leisons of Hashimoto thyroiditis， Riedel thyroiditis， and papillary thyroid carcinoma.
Conclusions 　IgG4-related thyroid disease is a new concept of thyroiditis. The knowledge of this new disease will provide appropriate treatment for patients with thyroiditis.

Citation： WANG Xunli,HUANG Qiushi,ZHU Xinxin,DU Zhenhong,CHEN Qiang,DENG Qiaolian,SUN Yinghe,CHEN Rui,WEI Tao,LIU Feng,MA Yu,GONG Rixiang,LI Zhihui,ZHU Jingqiang,.. IgG4 Related Thyroid Diseases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(9): 1075-1079. doi: Copy

1.	Li Y， Nishihara E， Hirokawa M， et al. Distinct clinical， serological， and sonographic characteristics of Hashimoto’s thyroiditisbased with and without IgG4-positive plasma cells[J]. J Clin Endocrinol Metab， 2010， 95(3)：1309-1317.
2.	冯敏，何菁，栗占国. IgG4相关性疾病及其器官损害命名的推荐意见[J]. 中华风湿病学杂志， 2012， 16(12)：853.
3.	Umehara H， Okazaki K， Masaki Y， et al. Comprehensive diagn-ostic criteria for IgG4-related disease (IgG4-RD)， 2011[J]. ModRheumatol， 2012， 22(1)：21-30.
4.	Zen Y， Fujii T， Harada K， et al. Th2 and regulatory immune reactions are increased in immunoglobulin G4-related sclerosingpancreatitis and cholangitis[J]. Hepatology， 2007， 45(6)：1538-1546.
5.	余成秀，罗雄燕，邹倩，等. IgG4与自身免疫病[J]. 中华风湿病学杂志， 2012， 16(12)：838-841.
6.	Akdis CA， Akdis M. Mechanisms and treatment of allergic dise-ase in the big picture of regulatory 7 cells[J]. J Allergy Clin Imm-unol， 2009， 123(4)：735-746.
7.	Hamano H， Kawa S， Horiuchi A， et al. High serum IgG4 conce-ntrations in patients with sclerosing pancreatitis[J]. N Engl J Med， 2001， 344(10)：732-738.
8.	Kamisawa T， Funata N， Hayashi Y， et al. A new clinicopathological entity of IgG4-related autoimmune disease[J]. J Gastroenterol， 2003， 38(10)：982-984.
9.	Kamisawa T， Nakajima H， Egawa N， et al. IgG4-related sclerosingdisease incorporating sclerosing pancreatitis， cholangitis， sialadenitis and retroperitoneal fibrosis with lymphadenopathy[J]. Pan-creatology， 2006， 6(1-2)：132-137.
10.	Masaki Y， Dong L， Kurose N， et al. Proposal for a new clinical entity， IgG4-positive multiorgan lymphoproliferative syndrome：analysis of 64 cases of IgG4-related disorders[J]. Ann Rheum Dis， 2009， 68(8)：1310-1315.
11.	Sato Y， Notohara K， Kojima M， et al. IgG4-related disease：historical overview and pathology of hematological disorders[J]. Pathol Int， 2010， 60(4)：247-258.
12.	Stone JH， Zen Y， Deshpande V. IgG4-related disease[J]. N Engl J Med， 2012， 366(6)：539-551.
13.	LiVolsi VA. The pathology of autoimmune thyroid disease：a review[J]. Thyroid， 1994， 4(3)：333-339.
14.	Hay ID. Thyroiditis：a clinical update[J]. Mayo Clin Proc， 1985， 60(12)：836-843.
15.	潘高云，夏建克，李选峰，等. 超声诊断桥本氏甲状腺炎78例分析[J]. 中国临床医学影像杂志， 2010， 21(4)：274-276.
16.	Hayashi N， Tamaki N， Konishi J， et al. Sonography of Hashimoto’s thyroiditis[J]. J Clin Ultrasound， 1986， 14(2)：123-126.
17.	Li Y， Bai Y， Liu Z， et al. Immunohistochemistry of IgG4 can help subclassify Hashimoto’s autoimmune thyroiditis [J]. Pathol Int， 2009， 59(9)：636-641.
18.	Kojima M， Hirokawa M， Kuma H， et al. Distribution of IgG4- and/or IgG-positive plasma cells in Hashimoto’s thyroiditis：an immunohistochemical study[J]. Pathobiology， 2010， 77(5)：267-272.
19.	Deshpande V， Huck A， Ooi E， et al. Fibrosing variant of Hashimoto thyroiditis is an IgG4-related disease[J]. J Clin Pathol， 2012， 65(8)：725-728.
20.	Li Y， Zhou G， Ozaki T， et al. Distinct histopathological features of Hashimoto’s thyroiditis with respect to IgG4-related disease[J]. Mod Pathol， 2012， 25(8)：1086-1097.
21.	Kakudo K， Li Y， Taniguchi E， et al. IgG4-related disease of the thyroid glands[J]. Endocr J， 2012， 59(4)：273-281.
22.	de Lange WE， Freling NJ， Molenaar WM， et al. Invasive fibrousthyroiditis (Riedel’s struma)：a manifestation of multifocal fibros-clerosis? A case report with review of the literature[J]. Q J Med，.
23.	Zimmermann-Belsing T， Feldt-Rasmussen U. Riedel’s thyroiditis：an autoimmune or primary fibrotic disease?[J]. J Intern Med， 1994， 235(3)：271-274.
24.	Sheu SY， Schmid KW. Inflammatory diseases of the thyroid gland. Epidemiology， symptoms and morphology[J]. Pathologe，.
25.	Eryaman E， Comunoglu C. Could Riedel’s thyroiditis be subacutethyroiditis? A case report[J]. Pol J Pathol， 2011， 62(3)：176-178.
26.	毛礼蛟，杨学全. Riedel甲状腺炎诊治进展[J]. 现代肿瘤医学， 2006， 14(9)：1164-1166.
27.	Drieskens O， Blockmans D， Van den Bruel A， et al. Riedel’s thyroiditis and retroperitoneal fibrosis in multifocal fibrosclerosis：positron emission tomographic findings[J]. Clin Nucl Med， 2002， 27(6)：413-415.
28.	Owen K， Lane H， Jones MK. Multifocal fibrosclerosis：a case of thyroiditis and bilateral lacrimal gland involvement[J]. Thyroid，.
29.	Hennessey JV. Clinical review：Riedel’s thyroiditis：a clinical review[J]. J Clin Endocrinol Metab， 2011， 96(10)：3031-3041.
30.	Nagashima T， Maruyama A， Takatori S， et al. Subclinical Riedel’sthyroiditis with hypothyroidism coexisting with Mikulicz’s disease[J]. Rheumatol Int， 2012， 32(6)：1851-1852.
31.	Lin L， Feng G， Wei XD， et al. Clinical and pathological features of Riedel’s thyroiditis[J]. Clin Med Sci J， 2010， 25(3)：129-134.
32.	Palazzo E， Palazzo C， Palazzo M. IgG4-related disease[J]. Joint Bone Spine， 2013， 6(1). [Epub ahead of print].
33.	Dahlgren M， Khosroshahi A， Nielsen GP， et al. Riedel’s thyroi-ditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum[J]. Arthritis Care Res (Hoboken)， 2010， 62(9)：1312-1318.
34.	Pusztaszeri M， Triponez F， Pache JC， et al. Riedel’s thyroiditis with increased IgG4 plasma cells：evidence for an underlying IgG4-related sclerosing disease?[J]. Thyroid， 2012， 22(9)：964-968.
35.	Fatourechi MM， Hay ID， McIver B， et al. Invasive fibrous thyr-oiditis (Riedel thyroiditis)：the Mayo Clinic experience， 1976-2008[J]. Thyroid， 2011， 21(7)：765-772.
36.	Ito M， Naruke Y， Mihara Y， et al. Thyroid papillary carcinoma with solid sclerosing change in IgG4-related sclerosing disease[J]. Pathol Int， 2011， 61(10)：589-592.
37.	， 72(268)：709-717.
38.	， 11(12)：1187-1190.
39.	， 24(5)：339-347.

1. Li Y， Nishihara E， Hirokawa M， et al. Distinct clinical， serological， and sonographic characteristics of Hashimoto’s thyroiditisbased with and without IgG4-positive plasma cells[J]. J Clin Endocrinol Metab， 2010， 95(3)：1309-1317.
2. 冯敏，何菁，栗占国. IgG4相关性疾病及其器官损害命名的推荐意见[J]. 中华风湿病学杂志， 2012， 16(12)：853.
3. Umehara H， Okazaki K， Masaki Y， et al. Comprehensive diagn-ostic criteria for IgG4-related disease (IgG4-RD)， 2011[J]. ModRheumatol， 2012， 22(1)：21-30.
4. Zen Y， Fujii T， Harada K， et al. Th2 and regulatory immune reactions are increased in immunoglobulin G4-related sclerosingpancreatitis and cholangitis[J]. Hepatology， 2007， 45(6)：1538-1546.
5. 余成秀，罗雄燕，邹倩，等. IgG4与自身免疫病[J]. 中华风湿病学杂志， 2012， 16(12)：838-841.
6. Akdis CA， Akdis M. Mechanisms and treatment of allergic dise-ase in the big picture of regulatory 7 cells[J]. J Allergy Clin Imm-unol， 2009， 123(4)：735-746.
7. Hamano H， Kawa S， Horiuchi A， et al. High serum IgG4 conce-ntrations in patients with sclerosing pancreatitis[J]. N Engl J Med， 2001， 344(10)：732-738.
8. Kamisawa T， Funata N， Hayashi Y， et al. A new clinicopathological entity of IgG4-related autoimmune disease[J]. J Gastroenterol， 2003， 38(10)：982-984.
9. Kamisawa T， Nakajima H， Egawa N， et al. IgG4-related sclerosingdisease incorporating sclerosing pancreatitis， cholangitis， sialadenitis and retroperitoneal fibrosis with lymphadenopathy[J]. Pan-creatology， 2006， 6(1-2)：132-137.
10. Masaki Y， Dong L， Kurose N， et al. Proposal for a new clinical entity， IgG4-positive multiorgan lymphoproliferative syndrome：analysis of 64 cases of IgG4-related disorders[J]. Ann Rheum Dis， 2009， 68(8)：1310-1315.
11. Sato Y， Notohara K， Kojima M， et al. IgG4-related disease：historical overview and pathology of hematological disorders[J]. Pathol Int， 2010， 60(4)：247-258.
12. Stone JH， Zen Y， Deshpande V. IgG4-related disease[J]. N Engl J Med， 2012， 366(6)：539-551.
13. LiVolsi VA. The pathology of autoimmune thyroid disease：a review[J]. Thyroid， 1994， 4(3)：333-339.
14. Hay ID. Thyroiditis：a clinical update[J]. Mayo Clin Proc， 1985， 60(12)：836-843.
15. 潘高云，夏建克，李选峰，等. 超声诊断桥本氏甲状腺炎78例分析[J]. 中国临床医学影像杂志， 2010， 21(4)：274-276.
16. Hayashi N， Tamaki N， Konishi J， et al. Sonography of Hashimoto’s thyroiditis[J]. J Clin Ultrasound， 1986， 14(2)：123-126.
17. Li Y， Bai Y， Liu Z， et al. Immunohistochemistry of IgG4 can help subclassify Hashimoto’s autoimmune thyroiditis [J]. Pathol Int， 2009， 59(9)：636-641.
18. Kojima M， Hirokawa M， Kuma H， et al. Distribution of IgG4- and/or IgG-positive plasma cells in Hashimoto’s thyroiditis：an immunohistochemical study[J]. Pathobiology， 2010， 77(5)：267-272.
19. Deshpande V， Huck A， Ooi E， et al. Fibrosing variant of Hashimoto thyroiditis is an IgG4-related disease[J]. J Clin Pathol， 2012， 65(8)：725-728.
20. Li Y， Zhou G， Ozaki T， et al. Distinct histopathological features of Hashimoto’s thyroiditis with respect to IgG4-related disease[J]. Mod Pathol， 2012， 25(8)：1086-1097.
21. Kakudo K， Li Y， Taniguchi E， et al. IgG4-related disease of the thyroid glands[J]. Endocr J， 2012， 59(4)：273-281.
22. de Lange WE， Freling NJ， Molenaar WM， et al. Invasive fibrousthyroiditis (Riedel’s struma)：a manifestation of multifocal fibros-clerosis? A case report with review of the literature[J]. Q J Med，.
23. Zimmermann-Belsing T， Feldt-Rasmussen U. Riedel’s thyroiditis：an autoimmune or primary fibrotic disease?[J]. J Intern Med， 1994， 235(3)：271-274.
24. Sheu SY， Schmid KW. Inflammatory diseases of the thyroid gland. Epidemiology， symptoms and morphology[J]. Pathologe，.
25. Eryaman E， Comunoglu C. Could Riedel’s thyroiditis be subacutethyroiditis? A case report[J]. Pol J Pathol， 2011， 62(3)：176-178.
26. 毛礼蛟，杨学全. Riedel甲状腺炎诊治进展[J]. 现代肿瘤医学， 2006， 14(9)：1164-1166.
27. Drieskens O， Blockmans D， Van den Bruel A， et al. Riedel’s thyroiditis and retroperitoneal fibrosis in multifocal fibrosclerosis：positron emission tomographic findings[J]. Clin Nucl Med， 2002， 27(6)：413-415.
28. Owen K， Lane H， Jones MK. Multifocal fibrosclerosis：a case of thyroiditis and bilateral lacrimal gland involvement[J]. Thyroid，.
29. Hennessey JV. Clinical review：Riedel’s thyroiditis：a clinical review[J]. J Clin Endocrinol Metab， 2011， 96(10)：3031-3041.
30. Nagashima T， Maruyama A， Takatori S， et al. Subclinical Riedel’sthyroiditis with hypothyroidism coexisting with Mikulicz’s disease[J]. Rheumatol Int， 2012， 32(6)：1851-1852.
31. Lin L， Feng G， Wei XD， et al. Clinical and pathological features of Riedel’s thyroiditis[J]. Clin Med Sci J， 2010， 25(3)：129-134.
32. Palazzo E， Palazzo C， Palazzo M. IgG4-related disease[J]. Joint Bone Spine， 2013， 6(1). [Epub ahead of print].
33. Dahlgren M， Khosroshahi A， Nielsen GP， et al. Riedel’s thyroi-ditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum[J]. Arthritis Care Res (Hoboken)， 2010， 62(9)：1312-1318.
34. Pusztaszeri M， Triponez F， Pache JC， et al. Riedel’s thyroiditis with increased IgG4 plasma cells：evidence for an underlying IgG4-related sclerosing disease?[J]. Thyroid， 2012， 22(9)：964-968.
35. Fatourechi MM， Hay ID， McIver B， et al. Invasive fibrous thyr-oiditis (Riedel thyroiditis)：the Mayo Clinic experience， 1976-2008[J]. Thyroid， 2011， 21(7)：765-772.
36. Ito M， Naruke Y， Mihara Y， et al. Thyroid papillary carcinoma with solid sclerosing change in IgG4-related sclerosing disease[J]. Pathol Int， 2011， 61(10)：589-592.
37. ， 72(268)：709-717.
38. ， 11(12)：1187-1190.
39. ， 24(5)：339-347.

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IgG4 Related Thyroid Diseases

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