Objective To summarize and analyze the different modality on molecular imaging of tracking and monitoring for islet transplantation.
Methods The current domestic and foreign reports on molecular imaging of islet transplantation were reviewed.
Results Magnetic resonance imaging has high sensitivity,high spatial resolution,no ionizing radiation,is clinically applicable,and could be used of real-time MR-guided injections,but can’t discriminate between liver and dead cells,difficult to do in patients with liver iron overload.Nuclear molecular imaging only displays liver cells generate signal,is clinically applicable,but disadvantage is genetic manipulation,ionizing radiation,no anatomical information,low spatial resolution.The advantage of in vivo optical imaging is only liver cells generate signal,widely available,no ionizing radiation,and the disadvantage is genetic manipulation,not clinically applicable,low spatial resolution.
Conclusions Islet imaging using magnetic resonance,nuclear molecular imaging,in vivo optical imaging,or multimodal imaging of microencapsulated islets may provide us with a direct means to interrogate islet cell distribution,survival,and function.Multimodal imaging of microencapsulated islets may be best way for tracking and monitoring in the future.
Citation: HUANG Zixing,LIU Yangyang,SONGBin,.. Molecular Imaging of Islet Transplantation:Tracking and Monitoring. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(2): 140-145. doi: Copy