Ultrasound Guided Combined with Laparoscopic Microwave Ablation in Treatment for Special Site Liver Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SUN WenYu , JIANG HongLei , YU Hao , XU Dong , LIANG Jian

Department of Hepatobiliary Surgery，The Fourth Affiliated Hospital of China Medical University， Shenyang 110032， Liaoning Province， China;

Corresponding author：

Keywords：

Ultrasound guided; Laparoscope; Microwave ablation; Liver cancer

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Objective 　To explore the clinical value and experience of ultrasound guided combined with laparoscopic microwave ablation in treatment for special site liver cancer．
Methods 　The clinical data of 9 patients with liver cancer treated by ultrasound guided combined with laparoscopic microwave ablation in our hospital from February 2008 to October 2010 were analyzed retrospectively．
Results 　There were 6 cases of primary liver cancer， 3 cases of metastatic hepatic carcinoma. Eight cases of multiple tumors， 1 case of single tumor．There were one or more lesions invading liver capsular，a total of 13 lesions in all the patients． Among them，6 lesions located in diaphragm， 3 closed to bowel， 2 neared stomach，1 located in gallbladder bed and 1 in hilar．No serious complications and no death happened during operation．The following-up time was （9.2±4.7） months （4 to 18 months）， there were 2 lesions of part residual， including 1 case of microwave ablation again，1 case of percutaneous ethanol ablation， and 11 lesions of complete ablation （84.6%，11/13） 1 month after operation by CT examination．Four cases recurred 3 months after operation by CT examination， including 2 cases of microwave ablation again，1 case of percutaneous ethanol ablation，1 patient with pulmonary metastasis and giving up treatment，1 patient with poor liver function and died of liver failure 6 months after operation；1 patient with multiple lesions died of brain metastases 10 months after operation； the rest were still alive．
Conclusions 　Ultrasound guided combined with laparoscopic microwave ablation is a safe and effective method in the treatment for special site liver cancer，the curative effect is good and worth of spread．

Citation： SUN WenYu,JIANG HongLei,YU Hao,XU Dong,LIANG Jian,.. Ultrasound Guided Combined with Laparoscopic Microwave Ablation in Treatment for Special Site Liver Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(2): 188-191. doi: Copy

1.	Lu MD，Xu HX，Xie XY，et al．Percutaneous microwave and radiofrequency ablation for hepatocellular carcinoma：a retrospective comparative study[J]．J Gastroenterol，2005，40(11)： 1054-1060．.
2.	Zhou Q，Jin X，Jiao DC，et al．Microwave ablation：results in ex vivo and in vivo porcine livers with 2 450-MHz cooled-shaft antenna[J]．Chin Med J (Engl)，2011，124(20)：3386-3393．.
3.	Bhardwaj N，Dormer J，Ahmad F，et al．Microwave ablation of the liver：a description of lesion evolution over time and an investigation of the heat sink effect[J]．Pathology，2011，43(7)：725731．.
4.	Simo KA，Sereika SE，Newton KN，et al．Laparoscopic-assisted microwave ablation for hepatocellular carcinoma：safety and efficacy in comparison with radiofrequency ablation[J]．J Surg Oncol，2011，104(7)：822-829．.
5.	Padma S，Martinie JB，Iannitti DA．Liver tumor ablation：per-cutaneous and open approaches[J]．J Surg Oncol，2009，100(8)： 619-634．.
6.	Müller C．Hepatocellular carcinoma-rising incidence，changing therapeutic strategies[J]．Wien Med Wochenschr，2006， 156(13-14）：404-409．.
7.	Poon RT，Fan ST，Lo CM，et al．Improving survival results after resection of hepatocellular carcinoma：a prospective study of 377 patients over 10 years[J]．Ann Surg，2001，234(1)：63-70．.
8.	Topal B，Aerts R，Penninckx F．Laparoscopic radiofrequency ablation of unresectable liver malignancies：feasibility and clinical outcome[J]．Surg Laparosc Endosc Percutan Tech，2003， 13(1)：11-15．.
9.	樊嘉，黄成．原发性肝癌外科治疗的进展[ J]．中国普外基础与临床杂志，2009，16(4)：257-260．.
10.	吴孟超．肝癌外科治疗的近期进展[ J]．中国普外基础与临床杂志，2006，13(2)：125-128．.
11.	Stauffer PR，Rossetto F，Prakash M，et al．Phantom and animal tissues for modelling the electrical properties of human liver[J]． Int J Hyperthermia，2003，19(1)：89-101．.
12.	Wright AS，Lee FT Jr，Mahvi DM．Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis[J]．Ann Surg Oncol，2003，10(3)：275283．.
13.	Shock SA，Meredith K，Warner TF，et al．Microwave ablation with loop antenna：in vivo porcine liver model[J]．Radiology， 2004，231(1)：143-149．.
14.	Shibata T，Iimuro Y，Yamamoto Y，et al．Small hepatocellular carcinoma：comparison of radio-frequency ablation and percutaneous microwave coagulation therapy[J]．Radiology，2002， 223(2)：331-337．.
15.	Bhardwaj N，Strickland AD，Ahmad F，et al．Microwave ablation for unresectable hepatic tumours：clinical results using a novel microwave probe and generator[J]．Eur J Surg Oncol， 2010，36(3)：264-268．.
16.	朱鹏，陈孝平．腹腔镜在肝脏外科中的应用[ J]．中国微创外科杂志，2007，7(6)：575-577．.
17.	任正刚．原发性肝癌的射频毁损治疗进展[ J]．中国普外基础与临床杂志，2007，14(1)：5-7．.
18.	Jagad RB，Koshariya M，Kawamoto J，et al．Laparoscopic microwave ablation of liver tumors：our experience[J]．Hepatogastroenterology，2008，55(81)：27-32．.
19.	宋希林，石学涛，宋金龙，等．腹腔镜引导定位肝脏肿瘤射频消融治疗的临床观察[ J]．中华肿瘤防治杂志， 2009，16(13)： 1025-1027．.
20.	Martin RC，Scoggins CR，McMasters KM．Safety and efficacy of microwave ablation of hepatic tumors：a prospective review of a 5-year experience[J]．Ann Surg Oncol，2010，17(1)：171178.
21.	Santambrogio R，Costa M，Barabino M，et al．Laparoscopic radiofrequency of hepatocellular carcinoma using ultrasound-guided selective intrahepatic vascular occlusion[J]．Surg Endosc， 2008，22(9)：2051-2055．.
22.	Abe T，Shinzawa H，Wakabayashi H，et al．Value of laparoscopic microwave coagulation therapy for hepatocellular carcinoma in relation to tumor size and location[J]．Endoscopy，2000， 32(8)：598-603．.

1. Lu MD，Xu HX，Xie XY，et al．Percutaneous microwave and radiofrequency ablation for hepatocellular carcinoma：a retrospective comparative study[J]．J Gastroenterol，2005，40(11)： 1054-1060．.
2. Zhou Q，Jin X，Jiao DC，et al．Microwave ablation：results in ex vivo and in vivo porcine livers with 2 450-MHz cooled-shaft antenna[J]．Chin Med J (Engl)，2011，124(20)：3386-3393．.
3. Bhardwaj N，Dormer J，Ahmad F，et al．Microwave ablation of the liver：a description of lesion evolution over time and an investigation of the heat sink effect[J]．Pathology，2011，43(7)：725731．.
4. Simo KA，Sereika SE，Newton KN，et al．Laparoscopic-assisted microwave ablation for hepatocellular carcinoma：safety and efficacy in comparison with radiofrequency ablation[J]．J Surg Oncol，2011，104(7)：822-829．.
5. Padma S，Martinie JB，Iannitti DA．Liver tumor ablation：per-cutaneous and open approaches[J]．J Surg Oncol，2009，100(8)： 619-634．.
6. Müller C．Hepatocellular carcinoma-rising incidence，changing therapeutic strategies[J]．Wien Med Wochenschr，2006， 156(13-14）：404-409．.
7. Poon RT，Fan ST，Lo CM，et al．Improving survival results after resection of hepatocellular carcinoma：a prospective study of 377 patients over 10 years[J]．Ann Surg，2001，234(1)：63-70．.
8. Topal B，Aerts R，Penninckx F．Laparoscopic radiofrequency ablation of unresectable liver malignancies：feasibility and clinical outcome[J]．Surg Laparosc Endosc Percutan Tech，2003， 13(1)：11-15．.
9. 樊嘉，黄成．原发性肝癌外科治疗的进展[ J]．中国普外基础与临床杂志，2009，16(4)：257-260．.
10. 吴孟超．肝癌外科治疗的近期进展[ J]．中国普外基础与临床杂志，2006，13(2)：125-128．.
11. Stauffer PR，Rossetto F，Prakash M，et al．Phantom and animal tissues for modelling the electrical properties of human liver[J]． Int J Hyperthermia，2003，19(1)：89-101．.
12. Wright AS，Lee FT Jr，Mahvi DM．Hepatic microwave ablation with multiple antennae results in synergistically larger zones of coagulation necrosis[J]．Ann Surg Oncol，2003，10(3)：275283．.
13. Shock SA，Meredith K，Warner TF，et al．Microwave ablation with loop antenna：in vivo porcine liver model[J]．Radiology， 2004，231(1)：143-149．.
14. Shibata T，Iimuro Y，Yamamoto Y，et al．Small hepatocellular carcinoma：comparison of radio-frequency ablation and percutaneous microwave coagulation therapy[J]．Radiology，2002， 223(2)：331-337．.
15. Bhardwaj N，Strickland AD，Ahmad F，et al．Microwave ablation for unresectable hepatic tumours：clinical results using a novel microwave probe and generator[J]．Eur J Surg Oncol， 2010，36(3)：264-268．.
16. 朱鹏，陈孝平．腹腔镜在肝脏外科中的应用[ J]．中国微创外科杂志，2007，7(6)：575-577．.
17. 任正刚．原发性肝癌的射频毁损治疗进展[ J]．中国普外基础与临床杂志，2007，14(1)：5-7．.
18. Jagad RB，Koshariya M，Kawamoto J，et al．Laparoscopic microwave ablation of liver tumors：our experience[J]．Hepatogastroenterology，2008，55(81)：27-32．.
19. 宋希林，石学涛，宋金龙，等．腹腔镜引导定位肝脏肿瘤射频消融治疗的临床观察[ J]．中华肿瘤防治杂志， 2009，16(13)： 1025-1027．.
20. Martin RC，Scoggins CR，McMasters KM．Safety and efficacy of microwave ablation of hepatic tumors：a prospective review of a 5-year experience[J]．Ann Surg Oncol，2010，17(1)：171178.
21. Santambrogio R，Costa M，Barabino M，et al．Laparoscopic radiofrequency of hepatocellular carcinoma using ultrasound-guided selective intrahepatic vascular occlusion[J]．Surg Endosc， 2008，22(9)：2051-2055．.
22. Abe T，Shinzawa H，Wakabayashi H，et al．Value of laparoscopic microwave coagulation therapy for hepatocellular carcinoma in relation to tumor size and location[J]．Endoscopy，2000， 32(8)：598-603．.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Ultrasound Guided Combined with Laparoscopic Microwave Ablation in Treatment for Special Site Liver Cancer

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