Establishment of A Rabbit Model of Lower Extremity Atherosclerosis Obliterans_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

冉继朋 ¹ , 马军 ² , 张天华 ² , 张英男 ²

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Keywords：

下肢动脉粥样硬化闭塞症; 兔; 模型

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目的　探索建立下肢动脉粥样硬化闭塞症动物模型的有效方法。
方法　30只雄性新西兰白兔随机分为3组，每组10只。空白组给予普通饲料喂养，对照组给予单纯高脂饲料喂养，实验组给予高脂饲料喂养及下肢动脉球囊损伤。实验第15周结束时观察兔下肢动脉病理形态学特征并检测血脂水平。
结果　第15周时，实验组和对照组动物血脂水平较空白组均明显升高（P＜0.05）；对照组和实验组动物均出现下肢动脉粥样硬化斑块，其中实验组内膜较空白组和对照组明显增厚（P＜0.01），高倍（×100）镜下可见明显的斑块及纤维帽结构。
结论　高脂饲料喂养与球囊损伤结合可成功建立兔下肢动脉粥样硬化闭塞症模型，方法简单、经济，可重复性强。

Citation： 冉继朋,马军,张天华,张英男. Establishment of A Rabbit Model of Lower Extremity Atherosclerosis Obliterans. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(2): 208-210. doi: Copy

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4.	Mutirangura P，Ruangsetakit C， Wongwanit C，et al. Atherosclerosis obliterans of the lower extremities in Thai patients[J]. J Med Assoc Thai，2006，89(10)：1612-1620．.
5.	Bogomolov MS，Sedov VM，Edovina LN，et al. The results of using cytoflavin in conservative treatment of patients with obliterating atherosclerosis of the lower extremity vessels[J]. Vestn Khir Im I I Grek， 2011，170(1)：43-46．.
6.	Owens AP 3rd，Passam FH， Antoniak S，et al. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin[J]. J Clin Invest， 2012，122(2)：558-568．.
7.	Leveen RF， Wolf GL， Villanueva TG. New rabbit atherosclerosis model for the investigation of transluminal angioplasty[J]. Invest Radiol，1982，17(5)：470-475．.
8.	Hines TG，Jacobson NL，Beitz DC，et al．Dietary Calcium and vitamin D： risk factors in the development of atherosclerosis in young goats[J]. J Nutr，1985， 115(2)：167-178．.
9.	Rittershaus CW，Miller DP， Thomas LJ，et al. Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis[J]. Arterioscler Thromb Vasc Biol，2000，20(9)： 2106-2112．.
10.	Imai H，Lee KT，Pastori S，et al. Atherosclerosis in rabbits． Architectural and subcellular alterations of smooth muscle cells of aortas in response to hyperlipemia[J]. Exp Mol Pathol，1966， 5(3)：273-310．.
11.	Poole JC，Florey HW. Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits[J]. J Pathol Bacteriol，1958，75(2)：245-251．.
12.	Fogelstrand P，Mellander S，Mattsson E. Increased vascular injury reduces the degree of intimal hyperplasia following angioplasty in rabbits[J]. J Vasc Res， 2011，48(4)：307-315．.
13.	Nakazawa G，Nakano M， Otsuka F，et al. Evaluation of polymer-based comparator drug-eluting stents using a rabbit model of iliac artery atherosclerosis[J]. Circ Cardiovasc Interv， 2011， 4(1)：38-46．.
14.	Matsuda S，Yamashita A，Sato Y，et al. Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits[J]. J Thromb Haemost， 2011，9(1)：201-208．.

1. van Lammeren GW， Moll FL， Borst GJ，et al. Atherosclerotic plaque biomarkers：beyond the horizon of the vulnerable plaque[J]. Curr Cardiol Rev， 2011，7(1)：22-27．.
2. Neefjes LA，Ten Kate GJ， Alexia R，et al. Accelerated subclinical coronary atherosclerosis in patients with familial hypercholesterolemia[J]. Atherosclerosis， 2011，219(2)：721-727．.
3. Mutirangura P，Ruangsetakit C， Wongwanit C，et al. Comparative study of the management of diabetic versus nondiabetic patients with atherosclerosis obliterans of the lower extremities[J]. Vascular，2008，16(6)：333-339．.
4. Mutirangura P，Ruangsetakit C， Wongwanit C，et al. Atherosclerosis obliterans of the lower extremities in Thai patients[J]. J Med Assoc Thai，2006，89(10)：1612-1620．.
5. Bogomolov MS，Sedov VM，Edovina LN，et al. The results of using cytoflavin in conservative treatment of patients with obliterating atherosclerosis of the lower extremity vessels[J]. Vestn Khir Im I I Grek， 2011，170(1)：43-46．.
6. Owens AP 3rd，Passam FH， Antoniak S，et al. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin[J]. J Clin Invest， 2012，122(2)：558-568．.
7. Leveen RF， Wolf GL， Villanueva TG. New rabbit atherosclerosis model for the investigation of transluminal angioplasty[J]. Invest Radiol，1982，17(5)：470-475．.
8. Hines TG，Jacobson NL，Beitz DC，et al．Dietary Calcium and vitamin D： risk factors in the development of atherosclerosis in young goats[J]. J Nutr，1985， 115(2)：167-178．.
9. Rittershaus CW，Miller DP， Thomas LJ，et al. Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis[J]. Arterioscler Thromb Vasc Biol，2000，20(9)： 2106-2112．.
10. Imai H，Lee KT，Pastori S，et al. Atherosclerosis in rabbits． Architectural and subcellular alterations of smooth muscle cells of aortas in response to hyperlipemia[J]. Exp Mol Pathol，1966， 5(3)：273-310．.
11. Poole JC，Florey HW. Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits[J]. J Pathol Bacteriol，1958，75(2)：245-251．.
12. Fogelstrand P，Mellander S，Mattsson E. Increased vascular injury reduces the degree of intimal hyperplasia following angioplasty in rabbits[J]. J Vasc Res， 2011，48(4)：307-315．.
13. Nakazawa G，Nakano M， Otsuka F，et al. Evaluation of polymer-based comparator drug-eluting stents using a rabbit model of iliac artery atherosclerosis[J]. Circ Cardiovasc Interv， 2011， 4(1)：38-46．.
14. Matsuda S，Yamashita A，Sato Y，et al. Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits[J]. J Thromb Haemost， 2011，9(1)：201-208．.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Establishment of A Rabbit Model of Lower Extremity Atherosclerosis Obliterans

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