Analysis of Features of Extracolonic Carcinoma Spectrum in Northeast Chinese with Hereditary Nonpolyposis Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Xiaoxia , TANG Yuanxin , SUN Gongping , LI Xin , ZHAO Meng , YAN Yifei , MENG Jin

Department of Gastrointestinal Surgery， The Fourth Affiliated Hospital， China Medical University， Shenyang 110032，Liaoning Province， China;

Corresponding author：

Keywords：

Hereditary nonpolyposis colorectal carcinoma; Extracolonic carcinoma; Features

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Objective 　To investigate the features of extracolonic carcinoma spectrum in Northeast Chinese with hereditary nonpolyposis colorectal cancer.
Methods 　The extracolonic carcinoma spectrum’s characteristics of 85 families registered in strict conformity with the HNPCC Amsterdam criteriaⅡwere analyzed retrospectively.
Results 　In the 85 HNPCC families， the tumorous patients were 509 cases，the primary tumors were 589 cases， among the total consisted of 219 cases of colon cancer， 91 cases of rectal cancer，and 279 cases of extracolonic cancer， the most common extracolonic carcinoma was lung cancer.
Conclusions 　Extracolonic carcinoma is an important part of cancer spectrum in HNPCC family， and the common extracolonic carcinoma in Northeast of Chinese are lung cancer， gastric cancer， endometrial cancer， liver cancer， and esophagus carcinoma.

Citation： LI Xiaoxia,TANG Yuanxin,SUN Gongping,LI Xin,ZHAO Meng,YAN Yifei,MENG Jin,.. Analysis of Features of Extracolonic Carcinoma Spectrum in Northeast Chinese with Hereditary Nonpolyposis Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(3): 288-291. doi: Copy

1.	Vasen HF， Mecklin JP， Khan PM， et al. The internationalcollaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC) [J]. Dis Colon Rectum， 1991， 34(5)： 424-425.
2.	Alvaro E， Alegre C， Perea J. Association between Lynch syndrome and renal carcinoma [J]. Rev Esp Enferm Dig， 2011，103(9)： 500-501.
3.	Dunlop MG， Farrington SM， Carothers AD. Cancer risk associated with germline DNA mismatch repair gene mutations [J].Hum Mol Genet， 1997， 6(1)： 105-110.
4.	Bauer CM， Ray AM， Halstead-Nussloch BA， et al. Hereditary prostate cancer as a feature of Lynch syndrome [J]. Fam Cancer，2011， 10(1)： 37-42.
5.	金黑鹰，崔龙，丁义江，等. 中国人遗传性非息肉病性结直肠癌临床病理特征分析 [J]. 中华胃肠外科杂志， 2005， 8(4)：316-318．.
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7.	Rustgi AK. Hereditary gastrointestinal polyposis and nonpolyposis syndromes [J]. N Engl J Med， 1994， 331(25)： 1694-1702.
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9.	Shin KH， Shin JH， Kim JH， et al. Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients： identification of three novel germ-line mutations in promoter of the hMSH2 gene [J]. Cancer Res， 2002， 62(1)：38-42.
10.	Lynch HT， Smyrk T. Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated review [J]. Cancer， 1996， 78 (6)： 1149-1167.
11.	Fidalgo P， Almeida MR， West S， et al. Detection of mutations in mismatch repair genes in portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach [J]. Eur J Hum Genet， 2000， 8(1)： 49-53.
12.	Kim JC， Kim HC， Roh SA， et al. hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer [J]. Cancer Detect Prev， 2001， 25(6)： 503-510.
13.	张渊智，张志芳，张帆，等. 中国人遗传性非息肉病性结直肠癌常见临床表型特征与肠外肿瘤谱分析 [J]．胃肠病学和肝病学杂志， 2011， 20(6）： 513-518．.
14.	金黑鹰，颜宏利，马修强，等. 中国人遗传性非息肉病性结直肠癌相关肿瘤谱及累计发病风险 [J]. 第二军医大学学报，2004， 25(2)： 133-135．.
15.	Lynch HT， Lynch JF. Hereditary nonpolyposis colorectal cancer [J]. Semin Surg Oncol， 2000， 18(4)： 305-313.
16.	Lynch HT， Smyrk TC， Watson P， et al. Genetics， natural history，tumor spectrum， and pathology of hereditary nonpolyposis colorectal cancer： an updated review [J]. Gastroenterology，1993， 104(5)： 1535-1549.
17.	Soravia C， Pocard M. Hereditary colorectal cancer associated with polyposis syndromes [J]. Ann Chir， 1999， 53(10)： 979-984.
18.	Grover S， Syngal S. Risk assessment， genetic testing， and management of Lynch syndrome [J]. J Natl Compr Canc Netw，2010， 8(1)： 98-105.
19.	Soravia C， Berk T， Cohen Z. Genetic testing and surgical decision making in hereditary colorectal cancer [J]. Int J Colorectal Dis， 2000， 15(1)： 21-28.
20.	Lynch HT. Hereditary nonpolyposis colorectal cancer (HNPCC) [J]. Cytogenet Cell Genet， 1999， 86(2)： 130-135.
21.	Lynch HT， Lanspa SJ， Boman BM， et al. Hereditary nonpolyposis colorectal cancer―Lynch syndromes Ⅰ and Ⅱ [J]. Gastroenterol Clin North Am， 1988， 17(4)： 679-712.
22.	Lynch HT， Watson P， Lanspa SJ， et al. Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes Ⅰ and Ⅱ) [J]. Dis Colon Rectum， 1988，31(6)： 439-444.
23.	Peel DJ， Ziogas A， Fox EA， et al. Characterization of hereditary nonpolyposis colorectal cancer families from a populationased series of cases [J]. J Natl Cancer Inst， 2000， 92(18)：1517-1522.
24.	de Vos tot Nederveen Cappel WH， Nagengast FM， Griffioen G，et al. Surveillance for hereditary nonpolyposis colorectal cancer：a long-term study on 114 families [J]. Dis Colon Rectum，2002， 45(12)： 1588-1594.
25.	Thodi G， Fostira F， Sandaltzopoulos R， et al. Screening of the DNA mismatch repair genes MLH1， MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families [J]. BMC Cancer， 2010， 10： 544.

1. Vasen HF， Mecklin JP， Khan PM， et al. The internationalcollaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC) [J]. Dis Colon Rectum， 1991， 34(5)： 424-425.
2. Alvaro E， Alegre C， Perea J. Association between Lynch syndrome and renal carcinoma [J]. Rev Esp Enferm Dig， 2011，103(9)： 500-501.
3. Dunlop MG， Farrington SM， Carothers AD. Cancer risk associated with germline DNA mismatch repair gene mutations [J].Hum Mol Genet， 1997， 6(1)： 105-110.
4. Bauer CM， Ray AM， Halstead-Nussloch BA， et al. Hereditary prostate cancer as a feature of Lynch syndrome [J]. Fam Cancer，2011， 10(1)： 37-42.
5. 金黑鹰，崔龙，丁义江，等. 中国人遗传性非息肉病性结直肠癌临床病理特征分析 [J]. 中华胃肠外科杂志， 2005， 8(4)：316-318．.
6. Vasen HF， Watson P， Mecklin JP， et al. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC， Lynch syndrome) proposed by the International Collaborative group on HNPCC [J]. Gastroenterology， 1999， 116(6)： 1453-1456.
7. Rustgi AK. Hereditary gastrointestinal polyposis and nonpolyposis syndromes [J]. N Engl J Med， 1994， 331(25)： 1694-1702.
8. Dieumegard B， Grandjouan S， Sabourin JC， et al. Extensive molecular screening for hereditary non-polyposis colorectal cancer [J]. Br J Cancer， 2000， 82(4)： 871-880.
9. Shin KH， Shin JH， Kim JH， et al. Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients： identification of three novel germ-line mutations in promoter of the hMSH2 gene [J]. Cancer Res， 2002， 62(1)：38-42.
10. Lynch HT， Smyrk T. Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated review [J]. Cancer， 1996， 78 (6)： 1149-1167.
11. Fidalgo P， Almeida MR， West S， et al. Detection of mutations in mismatch repair genes in portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach [J]. Eur J Hum Genet， 2000， 8(1)： 49-53.
12. Kim JC， Kim HC， Roh SA， et al. hMLH1 and hMSH2 mutations in families with familial clustering of gastric cancer and hereditary non-polyposis colorectal cancer [J]. Cancer Detect Prev， 2001， 25(6)： 503-510.
13. 张渊智，张志芳，张帆，等. 中国人遗传性非息肉病性结直肠癌常见临床表型特征与肠外肿瘤谱分析 [J]．胃肠病学和肝病学杂志， 2011， 20(6）： 513-518．.
14. 金黑鹰，颜宏利，马修强，等. 中国人遗传性非息肉病性结直肠癌相关肿瘤谱及累计发病风险 [J]. 第二军医大学学报，2004， 25(2)： 133-135．.
15. Lynch HT， Lynch JF. Hereditary nonpolyposis colorectal cancer [J]. Semin Surg Oncol， 2000， 18(4)： 305-313.
16. Lynch HT， Smyrk TC， Watson P， et al. Genetics， natural history，tumor spectrum， and pathology of hereditary nonpolyposis colorectal cancer： an updated review [J]. Gastroenterology，1993， 104(5)： 1535-1549.
17. Soravia C， Pocard M. Hereditary colorectal cancer associated with polyposis syndromes [J]. Ann Chir， 1999， 53(10)： 979-984.
18. Grover S， Syngal S. Risk assessment， genetic testing， and management of Lynch syndrome [J]. J Natl Compr Canc Netw，2010， 8(1)： 98-105.
19. Soravia C， Berk T， Cohen Z. Genetic testing and surgical decision making in hereditary colorectal cancer [J]. Int J Colorectal Dis， 2000， 15(1)： 21-28.
20. Lynch HT. Hereditary nonpolyposis colorectal cancer (HNPCC) [J]. Cytogenet Cell Genet， 1999， 86(2)： 130-135.
21. Lynch HT， Lanspa SJ， Boman BM， et al. Hereditary nonpolyposis colorectal cancer―Lynch syndromes Ⅰ and Ⅱ [J]. Gastroenterol Clin North Am， 1988， 17(4)： 679-712.
22. Lynch HT， Watson P， Lanspa SJ， et al. Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes Ⅰ and Ⅱ) [J]. Dis Colon Rectum， 1988，31(6)： 439-444.
23. Peel DJ， Ziogas A， Fox EA， et al. Characterization of hereditary nonpolyposis colorectal cancer families from a populationased series of cases [J]. J Natl Cancer Inst， 2000， 92(18)：1517-1522.
24. de Vos tot Nederveen Cappel WH， Nagengast FM， Griffioen G，et al. Surveillance for hereditary nonpolyposis colorectal cancer：a long-term study on 114 families [J]. Dis Colon Rectum，2002， 45(12)： 1588-1594.
25. Thodi G， Fostira F， Sandaltzopoulos R， et al. Screening of the DNA mismatch repair genes MLH1， MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families [J]. BMC Cancer， 2010， 10： 544.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of Features of Extracolonic Carcinoma Spectrum in Northeast Chinese with Hereditary Nonpolyposis Colorectal Cancer

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