Research Progress of Regulating The Endoplasmic Reticulum Stress Response to Inhibit Autophagy in Tumor Cells_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

TIAN Hao , HAN Zhuoyue , DAI Jingyou , ZHANG Xinchen

Department of Hepatobiliary Surgery and General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China;

Corresponding author：

Keywords：

Autophagy; Endoplasmic reticulum stress response; Unfolded protein response; Calcium

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Objective 　To realize the research progress of regulating the endoplasmic reticulum stress response to inhibit autophagy in tumor cells.
Method 　The literatures about regulating the endoplasmic reticulum stress response to inhibit autophagy in tumor cells were reviewed.
Result 　In the endoplasmic reticulum stress response induced by the release of calcium and accumulation of unfolded proteins, autophagy can be activated by several pathways, and to regulate physiological and pathological processes.
Conclusion 　Further research about the endoplasmic reticulum stress response in tumor cells need to be done to regulate the response factors to inhibit autophagy.

Citation： TIAN Hao,HAN Zhuoyue,DAI Jingyou,ZHANG Xinchen,.. Research Progress of Regulating The Endoplasmic Reticulum Stress Response to Inhibit Autophagy in Tumor Cells. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(4): 452-455. doi: Copy

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2.	He C， Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy [J]. Annu Rev Genet， 2009， 43： 67-93.
3.	De Duve C， Wattiaux R. Functions of lysosomes [J]. Annual review of physiology， 1966， 28： 435-492.
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5.	Singh R， Kaushik S， Wang Y， et al. Autophagy regulates lipid metabolism [J]. Nature， 2009， 458(7242)： 1131-1135.
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7.	Ogata M， Hino S， Saito A， et al. Autophagy is activated for cell survival after endoplasmic reticulum stress [J]. Mol Cell Biol，2006， 26(24)： 9220-9231.
8.	Kouroku Y， Fujita E， Tanida I， et al. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion， an essential step for autophagy formation [J]. Cell Death Differ， 2007， 14(2)： 230-239.
9.	Kim KW， Moretti L， Mitchell LR， et al. Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2 alpha in caspase-3/7-deficient cells [J]. Oncogene， 2010， 29(22)： 3241-3251.
10.	Rutkowski DT， Kaufman RJ. All roads Lead to ATF4 [J]. Dev Cell， 2003， 4(4)： 442-444.
11.	Tallóczy Z， Jiang W， Virgin HW 4th， et al. Regulation of starvation and virus-induced autophagy by the eIF2alpha kinase signaling pathway [J]. Proc Natl Acad Sci USA， 2002， 99(1)： 190-195.
12.	Carra S， Brunsting JF， Lambert H， et al. HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2 alpha phosphorylation [J]. J Biol Chem， 2009，284(9)： 5523-5532.
13.	Qiu W， Zhang J， Dekker MJ， et al. Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B [J]. Hepatology， 2011， 53(5)： 1515-1525.
14.	Calfon M， Zeng HQ， Urano F， et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA [J]. Nature， 2002， 415(6867)： 92-96.
15.	Lee AH， Chu GC, Iwakoshi NN， et al. XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands [J].EMBO J， 2005， 24(24)： 4368-4380.
16.	Hetz C， Thielen P， Matus S， et al. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy [J]. Genes Dev， 2009, 23(19)： 2294-2306.
17.	Shimizu S， Konishi A， Nishida Y， et al. Involvement of JNK in the regulation of autophagic cell death [J]. Oncogene， 2010，29(14)： 2070-2082.
18.	Xu P， Das M, Reilly J， et al. JNK regulates FoxO-dependent autophagy in neurons [J]. Genes Dev， 2011， 25(4)： 310-322.
19.	Mathew R, Karp CM， Beaudoin B， et al. Autophagy suppresses tumorigenesis through elimination of p62 [J]. Cell， 2009，137(6)： 1062-1075.
20.	Park KJ， Lee SH， Lee CH， et al. Upregulation of beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death [J]. Biochem Biophys Res Commun， 2009, 382(4)： 726-729.
21.	Duan WJ， Li QS， Xia MY， et al. Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways[J]. Biol Pharm Bull， 2011， 34(1)： 47-53.
22.	Li DD， Wang LL， Deng R， et al. The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells [J]. Oncogene， 2009，28(6)： 886-898.
23.	Kim MJ， Woo SJ， Yoon CH， et al. Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation [J]. J Biol Chem, 2011， 286(15)： 12924-12932.
24.	Ding WX， Ni HM， Gao W， et al. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability [J]. Am J Pathol,2007， 171(2)： 513-524.
25.	Komiya K， Uchida T， Ueno T， et al. Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway [J]. Biochem Biophys Res Commun， 2010， 401(4)： 561-567.
26.	Høyer-Hansen M， Bastholm L， Szyniarowski P， et al. Control of macroautophagy by Calcium， Calmodulin-Dependent kinase Kinase-β， and Bcl-2 [J]. Mol Cell， 2007， 25(2)： 193-205.
27.	Hardie DG. AMPK： a key regulator of energy balance in the single cell and the whole organism [J]. Int J Obes， 2008， 32 Suppl 4： S7-S12.
28.	Herrero-Martín G， Høyer-Hansen M， García-García C， et al. TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells [J]. EMBO J， 2009， 28(6)： 677-685.
29.	Budanov AV， Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling [J]. Cell， 2008，134(3)： 451-460.
30.	Grotemeier A， Alers S， Pfisterer SG， et al. AMPK-independent induction of autophagy by cytosolic Ca2＋ increase [J]. Cell Signal，2010， 22(6)： 914-925.
31.	Bialik S， Kimchi A. The death-associated protein kinases： structure，function， and beyond [J]. Annu Rev Biochem， 2006， 75：189-210.
32.	Zalckvar E， Berissi H， Mizrachy L， et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy [J].EMBO Rep， 2009， 10(3)： 285-292.
33.	Gozuacik D， Bialik S， Raveh T， et al. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death [J]. Cell Death Differ， 2008， 15(12)：1875-1886.
34.	Sakaki K， Wu J， Kaufman RJ. Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum [J]. J Biol Chem， 2008， 283(22)： 15370-15380.
35.	Vicencio JM， Ortiz C， Criollo A， et al. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1 [J]. Cell Death Differ， 2009， 16(7)： 1006-1017.
36.	Vicencio JM， Lavandero S， Szabadkai G. Ca2 ＋， autophagy and protein degradation： thrown off balance in neurodegenerative disease [J]. Cell Calcium， 2010， 47(2)： 112-121.
37.	Wojcikiewicz RJ， Pearce MM， Sliter DA， et al. When worlds collide： IP(3) receptors and the ERAD pathway [J]. Cell Calcium，2009， 46(3)： 147-153.

1. Yorimitsu T， Klionsky DJ. Endoplasmic reticulum stress： a new pathway to induce autophagy [J]. Autophagy， 2007， 3(2)： 160-162.
2. He C， Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy [J]. Annu Rev Genet， 2009， 43： 67-93.
3. De Duve C， Wattiaux R. Functions of lysosomes [J]. Annual review of physiology， 1966， 28： 435-492.
4. Yorimitsu T， Klionsky DJ. Autophagy： molecular machinery for self-eating [J]. Cell Death Differ， 2005， 12(Suppl 2)： 1542-1552.
5. Singh R， Kaushik S， Wang Y， et al. Autophagy regulates lipid metabolism [J]. Nature， 2009， 458(7242)： 1131-1135.
6. Li J， Ni M， Lee B， et al. The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells [J]. Cell DeathDiffer， 2008， 15(9)： 1460-1471.
7. Ogata M， Hino S， Saito A， et al. Autophagy is activated for cell survival after endoplasmic reticulum stress [J]. Mol Cell Biol，2006， 26(24)： 9220-9231.
8. Kouroku Y， Fujita E， Tanida I， et al. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion， an essential step for autophagy formation [J]. Cell Death Differ， 2007， 14(2)： 230-239.
9. Kim KW， Moretti L， Mitchell LR， et al. Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2 alpha in caspase-3/7-deficient cells [J]. Oncogene， 2010， 29(22)： 3241-3251.
10. Rutkowski DT， Kaufman RJ. All roads Lead to ATF4 [J]. Dev Cell， 2003， 4(4)： 442-444.
11. Tallóczy Z， Jiang W， Virgin HW 4th， et al. Regulation of starvation and virus-induced autophagy by the eIF2alpha kinase signaling pathway [J]. Proc Natl Acad Sci USA， 2002， 99(1)： 190-195.
12. Carra S， Brunsting JF， Lambert H， et al. HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2 alpha phosphorylation [J]. J Biol Chem， 2009，284(9)： 5523-5532.
13. Qiu W， Zhang J， Dekker MJ， et al. Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B [J]. Hepatology， 2011， 53(5)： 1515-1525.
14. Calfon M， Zeng HQ， Urano F， et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA [J]. Nature， 2002， 415(6867)： 92-96.
15. Lee AH， Chu GC, Iwakoshi NN， et al. XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands [J].EMBO J， 2005， 24(24)： 4368-4380.
16. Hetz C， Thielen P， Matus S， et al. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy [J]. Genes Dev， 2009, 23(19)： 2294-2306.
17. Shimizu S， Konishi A， Nishida Y， et al. Involvement of JNK in the regulation of autophagic cell death [J]. Oncogene， 2010，29(14)： 2070-2082.
18. Xu P， Das M, Reilly J， et al. JNK regulates FoxO-dependent autophagy in neurons [J]. Genes Dev， 2011， 25(4)： 310-322.
19. Mathew R, Karp CM， Beaudoin B， et al. Autophagy suppresses tumorigenesis through elimination of p62 [J]. Cell， 2009，137(6)： 1062-1075.
20. Park KJ， Lee SH， Lee CH， et al. Upregulation of beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death [J]. Biochem Biophys Res Commun， 2009, 382(4)： 726-729.
21. Duan WJ， Li QS， Xia MY， et al. Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways[J]. Biol Pharm Bull， 2011， 34(1)： 47-53.
22. Li DD， Wang LL， Deng R， et al. The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells [J]. Oncogene， 2009，28(6)： 886-898.
23. Kim MJ， Woo SJ， Yoon CH， et al. Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation [J]. J Biol Chem, 2011， 286(15)： 12924-12932.
24. Ding WX， Ni HM， Gao W， et al. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability [J]. Am J Pathol,2007， 171(2)： 513-524.
25. Komiya K， Uchida T， Ueno T， et al. Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway [J]. Biochem Biophys Res Commun， 2010， 401(4)： 561-567.
26. Høyer-Hansen M， Bastholm L， Szyniarowski P， et al. Control of macroautophagy by Calcium， Calmodulin-Dependent kinase Kinase-β， and Bcl-2 [J]. Mol Cell， 2007， 25(2)： 193-205.
27. Hardie DG. AMPK： a key regulator of energy balance in the single cell and the whole organism [J]. Int J Obes， 2008， 32 Suppl 4： S7-S12.
28. Herrero-Martín G， Høyer-Hansen M， García-García C， et al. TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells [J]. EMBO J， 2009， 28(6)： 677-685.
29. Budanov AV， Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling [J]. Cell， 2008，134(3)： 451-460.
30. Grotemeier A， Alers S， Pfisterer SG， et al. AMPK-independent induction of autophagy by cytosolic Ca2＋ increase [J]. Cell Signal，2010， 22(6)： 914-925.
31. Bialik S， Kimchi A. The death-associated protein kinases： structure，function， and beyond [J]. Annu Rev Biochem， 2006， 75：189-210.
32. Zalckvar E， Berissi H， Mizrachy L， et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy [J].EMBO Rep， 2009， 10(3)： 285-292.
33. Gozuacik D， Bialik S， Raveh T， et al. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death [J]. Cell Death Differ， 2008， 15(12)：1875-1886.
34. Sakaki K， Wu J， Kaufman RJ. Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum [J]. J Biol Chem， 2008， 283(22)： 15370-15380.
35. Vicencio JM， Ortiz C， Criollo A， et al. The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1 [J]. Cell Death Differ， 2009， 16(7)： 1006-1017.
36. Vicencio JM， Lavandero S， Szabadkai G. Ca2 ＋， autophagy and protein degradation： thrown off balance in neurodegenerative disease [J]. Cell Calcium， 2010， 47(2)： 112-121.
37. Wojcikiewicz RJ， Pearce MM， Sliter DA， et al. When worlds collide： IP(3) receptors and the ERAD pathway [J]. Cell Calcium，2009， 46(3)： 147-153.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress of Regulating The Endoplasmic Reticulum Stress Response to Inhibit Autophagy in Tumor Cells

Abstract Full text Figures/Tables Video References Cited by

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