Use of Liver Graft from Pediatric Donor of Donation after Cardiac Death in Adult Recipient （Report of One Case）_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WEI Lin , ZHU Zhijun , DONG Chong , GAO Wei , YANG Tao , SUN Liying , QU Wei , RAO Wei , SUN Xiaoye , SHEN Zhongyang

Department of Transplantation， Tianjin First Central Hospital， Tianjin 300192， China;

Corresponding author：

Keywords：

Liver transplantation; Donation after cardiac death; Pediatric donor; Postoperative complications

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Objective 　To discuss the criteria of recipient selection，surgical approach，and complications and its theray by using of pediatric donation after cardiac death liver graft in adult recipient.
Methods 　The clinical data of one case of pediatric donation after cardiac death liver to adult recipient was analyzed retrospectively and the literatures were reviewed.
Results 　A 6-year-old girl pronounced brain death due to drowning and on the basis of cardiopulmonary criteria donated the organ．The liver graft weight was 598 g and the warm ischemic time was 10 min. The liver donor was transplanted to a 64-year-old woman，the graft to recipient weight ratio was 1.09%，the graft volume/estimated standard liver volume was 61.8%．The classic orthotopic liver transplantation without bypass was underwent，the postoperative recovery was smooth after the liver transplantation．The CT scan showed that the liver graft volume was 1 003cm3 on day 14 after operation．The patient was discharged on 45 d after orthotopic liver transplantation and the liver function was normal when followed-up 3 months after the operation.
Conclusions 　Pediatric donation after cardiac death liver graft can be successfully utilized to adult recipient．Recipient selection and surgical approach should be decided by conditions of both donor and graft．

Citation： WEI Lin,ZHU Zhijun,DONG Chong,GAO Wei,YANG Tao,SUN Liying,QU Wei,RAO Wei,SUN Xiaoye,SHEN Zhongyang,.. Use of Liver Graft from Pediatric Donor of Donation after Cardiac Death in Adult Recipient （Report of One Case）. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(5): 490-492. doi: Copy

1.	Shore PM, Huang R, Roy L, et al．Potential for liver and kidney donation after circulatory death in infants and children [J]. Pediatrics,2011, 128(3)： e631-e638．.
2.	Grewal HP, Willingham DL, Nguyen J, et al．Liver transplantation using controlled donation after cardiac death donors：an analysis of a large single-center experience [J]. Liver Transpl,2009, 15(9)：1028-1035．.
3.	Chaib E, Massad E．The potential impact of using donations after cardiac death on the liver transplantation program and waiting list in the state of Sao Paulo, Brazil [J]. Liver Transpl, 2008, 14(12)：1732-1736．.
4.	Klein AS, Messersmith EE, Ratner LE, et al．Organ donation and utilization in the United States, 1999-2008 [J]. Am J Transplant,2010, 10(4 Pt 2)：973-986．.
5.	Mateo R, Cho Y, Singh G, et al．Risk factors for graft survival after liver transplantation from donation after cardiac death donors：an analysis of OPTN/UNOS data [J]. Am J Transplant,2006, 6(4)：791-796．.
6.	Merion RM, Pelletier SJ, Goodrich N, et al．Donation after cardiac death as a strategy to increase deceased donor liver availability [J]. Ann Surg, 2006, 244(4)：555-562．.
7.	Selck FW, Grossman EB, Ratner LE, et al．Utilization, outcomes,and retransplantation of liver allografts from donation after cardiac death：implications for further expansion of the deceased-donor pool [J]. Ann Surg, 2008, 248(4)：599-607．.
8.	Chan EY, Olson LC, Kisthard JA, et al．Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors [J]. Liver Transpl, 2008, 14(5)：604-610．.
9.	Fujita S, Mizuno S, Fujikawa T, et al．Liver transplantation from donation after cardiac death：a single center experience [J].Transplantation, 2007, 84(1)：46-49．.
10.	de Vera ME, Lopez-Solis R, Dvorchik I, et al．Liver transplantation using donation after cardiac death donors：long-term followup from a single center [J]. Am J Transplant, 2009, 9(4)：773-781．.
11.	中华人民共和国卫生部医疗服务监管司. 卫生部办公厅关于启动心脏死亡捐献器官移植试点工作的通知( 附件1 －中国心脏死亡器官捐献分类标准.doc) [EB/OL]. http://www. moh.gov. cn/publicfiles/business/htmlfiles/zwgkzt/s9968/201104/51516.htm.
12.	Kolovos NS, Webster P, Bratton SL．Donation after cardiac death in pediatric critical care [J]. Pediatr Crit Care Med, 2007, 8(1)：47-49．.
13.	Emre S, Soejima Y, Altaca G, et al．Safety and risk of using pediatric donor livers in adult liver transplantation [J]. Liver Transpl,2001, 7(1)：41-47．.
14.	Adam R, Castaing D, Bismuth H．Transplantation of small donor livers in adult recipients [J]. Transplant Proc, 1993, 25(1 Pt 2)：1105-1106．.
15.	Yasutomi M, Harmsmen S, Innocenti F, et al．Outcome of the use of pediatric donor livers in adult recipients [J]. Liver Transpl,2001, 7(1)：38-40．.
16.	Ghabril M, Dickson RC, Krishna M, et al．Liver transplantation using young pediatric donor grafts in adults with hepatitis C infection [J]. Transplantation, 2009, 87(8)：1174-1179．.

1. Shore PM, Huang R, Roy L, et al．Potential for liver and kidney donation after circulatory death in infants and children [J]. Pediatrics,2011, 128(3)： e631-e638．.
2. Grewal HP, Willingham DL, Nguyen J, et al．Liver transplantation using controlled donation after cardiac death donors：an analysis of a large single-center experience [J]. Liver Transpl,2009, 15(9)：1028-1035．.
3. Chaib E, Massad E．The potential impact of using donations after cardiac death on the liver transplantation program and waiting list in the state of Sao Paulo, Brazil [J]. Liver Transpl, 2008, 14(12)：1732-1736．.
4. Klein AS, Messersmith EE, Ratner LE, et al．Organ donation and utilization in the United States, 1999-2008 [J]. Am J Transplant,2010, 10(4 Pt 2)：973-986．.
5. Mateo R, Cho Y, Singh G, et al．Risk factors for graft survival after liver transplantation from donation after cardiac death donors：an analysis of OPTN/UNOS data [J]. Am J Transplant,2006, 6(4)：791-796．.
6. Merion RM, Pelletier SJ, Goodrich N, et al．Donation after cardiac death as a strategy to increase deceased donor liver availability [J]. Ann Surg, 2006, 244(4)：555-562．.
7. Selck FW, Grossman EB, Ratner LE, et al．Utilization, outcomes,and retransplantation of liver allografts from donation after cardiac death：implications for further expansion of the deceased-donor pool [J]. Ann Surg, 2008, 248(4)：599-607．.
8. Chan EY, Olson LC, Kisthard JA, et al．Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors [J]. Liver Transpl, 2008, 14(5)：604-610．.
9. Fujita S, Mizuno S, Fujikawa T, et al．Liver transplantation from donation after cardiac death：a single center experience [J].Transplantation, 2007, 84(1)：46-49．.
10. de Vera ME, Lopez-Solis R, Dvorchik I, et al．Liver transplantation using donation after cardiac death donors：long-term followup from a single center [J]. Am J Transplant, 2009, 9(4)：773-781．.
11. 中华人民共和国卫生部医疗服务监管司. 卫生部办公厅关于启动心脏死亡捐献器官移植试点工作的通知( 附件1 －中国心脏死亡器官捐献分类标准.doc) [EB/OL]. http://www. moh.gov. cn/publicfiles/business/htmlfiles/zwgkzt/s9968/201104/51516.htm.
12. Kolovos NS, Webster P, Bratton SL．Donation after cardiac death in pediatric critical care [J]. Pediatr Crit Care Med, 2007, 8(1)：47-49．.
13. Emre S, Soejima Y, Altaca G, et al．Safety and risk of using pediatric donor livers in adult liver transplantation [J]. Liver Transpl,2001, 7(1)：41-47．.
14. Adam R, Castaing D, Bismuth H．Transplantation of small donor livers in adult recipients [J]. Transplant Proc, 1993, 25(1 Pt 2)：1105-1106．.
15. Yasutomi M, Harmsmen S, Innocenti F, et al．Outcome of the use of pediatric donor livers in adult recipients [J]. Liver Transpl,2001, 7(1)：38-40．.
16. Ghabril M, Dickson RC, Krishna M, et al．Liver transplantation using young pediatric donor grafts in adults with hepatitis C infection [J]. Transplantation, 2009, 87(8)：1174-1179．.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Use of Liver Graft from Pediatric Donor of Donation after Cardiac Death in Adult Recipient （Report of One Case）

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