Analysis on Prognostic Factors of 351 Patients with Gastric Cancer Underwent Gastrectomy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Bei , LU ChengYu , XIE HongHu

Department of General Surgery, Affiliated Nanjing Hospital (First Hospital of Nanjing City), Nanjing Medical University, Nanjing 210006, Jiangsu Province, China;

Corresponding author：

Keywords：

Gastric cancer; Prognostic factor; Survival rate

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Objective 　To investigate the prognostic factors related to long-term survival after gastrectomy.
Methods 　A total of 351 patients with gastric cancer who underwent gastrectomy were successfully followed-up in our hospital had been selected from January 2004 to December 2009. The clinicopathological and follow-up data were studied by univariate and multivariate analysis.
Results 　The age, location of tumors, T stage, N stage, TNM stage, and differentiation were related with postoperative survival of patients with gastric cancer by using univariate analysis（P＜0.05）. By using multivariate analysis, location of tumors, T stage, N stage, and chemotherapy were independent prognostic factors（P＜0.05）. Conclusions 　Location of tumors, depth of tumor invation, lymph node metastasis, and chem-otherapy were independent prognostic factors for gastric cancer patients who underwent gastrectomy. Chemotherapy after surgery could increase the survival rate of gastric cancer patients with lymph node metastasis or in TNM stage Ⅲ.

Citation： WANG Bei,LU ChengYu,XIE HongHu,.. Analysis on Prognostic Factors of 351 Patients with Gastric Cancer Underwent Gastrectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(7): 743-748. doi: Copy

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1. Jemal A， Siegel R， Ward E， et al. Cancer Statistics， 2008 [J].CA Cancer J Clin， 2008， 58：71-96.
2. 孙秀娣，牧人，周有尚，等. 中国胃癌死亡率20 年变化情况分析及其发展趋势预测 [J]. 中华肿瘤杂志， 2004， 26(5)：4-9.
3. Hmilton SR， Aahonen LA. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System [M]. Lyon：IARC Press， 2000：38-39.
4. Washington K. 7th Edition of the AJCC Cancer Staging Manual：Stomach [J]. Ann Surg Oncol， 2010， 17(12)：3077-3079.
5. Ling Yang. Incidence and mortality of gastric cancer in China[J]. World J Gastroenterol， 2006， 12(1)：17-20.
6. Steevens J， Schouten LJ， Goldbohm RA， et al. Alcohol consumption，cigarette smoking and risk of subtypes of oesophageal and gastric cancer：a prospective cohort study [J]. Gut， 2010，59(1)：39-48.
7. Furukawa H， Iwanaga T， Koyama H， et al. Effects of sex hormones on carcinogenesis in the stomach of rats [J]. Cancer Res，1982，42(12)：5181-5182.
8. Lee SA， Kang D， Shim KN， et al. Effect of diet and helicobacter pylori inection to the risk of early gastric cancer [J]. J Epidemiol，2003， 13(9)：162-168.
9. Maguire A， Porta M， Sanz-Anquela JM， et al. Sex as a prognostic factor in gastric cancer [J]. Eur J Cancer， 1996， 32A(8)：1303-1309.
10. Alici S， Kaya S， Izmirli M， et al. Analysis of survival factors in patients with advanced-stage gastric adenocarcinoma [J]. Med Sci Monit， 2006， 12(5)：221-229.
11. 彭俊生，詹文华，陈正煊，等. 不同年龄段胃癌患者的临床病理特点与预后分析 [J]. 中华胃肠外科杂志， 2004， 7(5)：349-352.
12. Rabunal RR， Pita SF， Rigueiro MT， et al. Presentation and Prognosis of gastric cancer in patients aged 80 years and older[J].World J Surg， 2004， 28(2)：155-159.
13. Cunningham SC， Kamangar F， Kim MP， et al. Survival after gastric adenocarcinoma resection：eighteen-year experience at a single institution [J]. J Gastrointest Surg， 2005， 9(5)：718-725.
14. Hassan HA， Sharma VK， Raufman JP. Changing trends in gastric carcinoma at a university medical center：a twelve year retrospective analysis [J]. J Clin Gastroenterol， 2001， 32(1)：37-40.
15. Pacelli F， Papa V， Caprino P， et al. Proximal compared with distal gastric cancer：multivariate analysis of prognostic factors [J]. Am Surg， 2001， 67(7)：697-703.
16. 封凯，刘智毅，林飞. 近远端胃癌预后差异及临床病理特点分析 [J]. 中华现代外科学杂志， 2009， 6(9)：533-537.
17. Piso P， Werner U， Lang H， et al. Proxmal versus distal gastric carcinoma——what are the differences？[ J]. Ann Surg Oncol，2000， 7(7)：520-525.
18. Siewert JR， Bottcher K， Stein HJ， et al. Relevant prognostic factors in gastric cancer：ten-years results of the German Gastric Cancer Study [J]. Ann Surg， 1998， 228(4)：449-461.
19. 冯润华，朱正纲，燕敏，等. 淋巴结转移率对T2 ～ T3 期胃癌患者预后评估的价值 [J]. 中华胃肠外科杂志， 2007， 10(5)：431-435.
20. 谢洪虎，吕成余，陈维，等. 958 例胃癌临床病理资料分析 [J]. 中国普外基础与临床杂志， 2011， 18(2)：153-158.
21. Maruyama K. The most important prognostic factors for gastric cancer patients：a study using univariate and multivariate analyses [J]. Scand J Gastroenterol， 1987， 22：63-68.
22. 詹友庆，孙晓卫，李威. 影响根治术后胃癌预后的多因素分析 [J]. 癌症， 2005， 24(5)：596.
23. 陈凛，张勇，卫勃，等. 2335 例胃癌外科治疗的临床分析 [J].中华胃肠外科杂志， 2007， 10(5)：421-424.
24. Panzini I， Gianni L， Fattori PP， et al. Adjuvant chemotherapy in agstric cancer：a meta-analysis of randomised trials and a comparison with privious meta-analyses [J]. Tumori， 2002， 88(1)：21-27.
25. Sun P， Xiang JB， Chen ZY. Meta-analysis of adjuvant chemotherapy after radical surgery for advanced gastric cancer [J]. Br J Surg， 2009， 96(1)：26-33.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis on Prognostic Factors of 351 Patients with Gastric Cancer Underwent Gastrectomy

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