Expression of Chemokine Receptor CXCR7 in Papillary Thyroid Carcinoma and Its Significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Zhen , SUN Daxin , MENG Xiangpeng , XU Weixue , WANG Baosheng

Department of Pancreas and Thyroid Surgery， Affiliated Shengjing Hospital， China Medical University， Shenyang 110004， Liaoning Province， China;

Corresponding author：

Keywords：

Thyroid neoplasm; Chemokine receptor; CXCR7

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective 　To investigate the expression of chemokine receptor CXCR7 and the relation between its expression and clinicopathologic characteristics in papillary thyroid carcinoma.
Method 　The expressions of CXCR7 in 79 cases of papillary thyroid carcinoma and their paracancerous tissues，and 33 cases of benign thyroid lesion tissues were detected by immunohistochemistry.
Results 　The positive expression rates of CXCR7 were 0（0/79），65.8%（52/79），and 30.3%（10/33） in the paracancerous tissues，papillary thyroid carcinoma tissues，and benign thyroid lesions tissues，respectively. The positive expression rate of CXCR7 in the papillary thyroid carcinoma tissues was significantly higher than that in the paracancerous tissues （P＜0.05） or benign thyroid lesion tissues（P＜0.05）. The expression of CXCR7 was correlated with lymph node metastasis （P＜0.05）.
Conclusion 　CXCR7 might take part in tumorigenesis，progression，and lymph node metastasis of papillary thyroid carcinoma.

Citation： LIU Zhen,SUN Daxin,MENG Xiangpeng,XU Weixue,WANG Baosheng,.. Expression of Chemokine Receptor CXCR7 in Papillary Thyroid Carcinoma and Its Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(8): 828-830. doi: Copy

1.	Raman D， Baugher PJ， Yee MT， et al. Role of chemokines in tumor growth[J]. Cancer Lett， 2007， 256(2)：137-165.
2.	Müller A， Homey B， Soto H， et al. Involvement of chemokine receptors in breast cancer metastasis[J]. Nature， 2001， 410(6824)：50-56.
3.	Kucia M， Reca R， Miekus K， et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms：pivotal role of the SDF-1-CXCR4 axis[J]. Stem Cells， 2005， 23(7)：879-894.
4.	Hartmann TN， Burger JA， Glodek A， et al. CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells[J]. Oncogene， 2005， 24(27)：4462-4471.
5.	Libura J， Drukala J， Majka M， et al. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion， chemotaxis， and adhesion[J]. Blood， 2002， 100(7)：2597-2606.
6.	熊斌，王崇树. 趋化因子受体CXCR4和CCR7在甲状腺癌中的表达及其临床病理意义[J]. 中国普外基础与临床杂志， 2011， 18(12)：1301-1304.
7.	Iwakiri S， Mino N， Takahashi T， et al. Higher expression of chemokine receptor CXCR7 is linked to early and metastaticrecurrence in pathological stageⅠ nonsmall cell lung cancer[J]. Cancer， 2009， 115(11)：2580-2593.
8.	Hattermann K， Held-Feindt J， Lucius R， et al. The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects[J]. Cancer Res， 2010， 70(8)：3299-3308.
9.	Zheng K， Li HY， Su XL， et al. Chemokine receptor CXCR7 regulates the invasion， angiogenesis and tumor growth of humanhepatocellular carcinoma cells[J]. J Exp Clin Cancer Res， 2010， 29：31.
10.	Singh RK， Lokeshwar BL. The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth[J]. Cancer Res， 2011， 71(9)：3268-3277.
11.	Rahman MA， Dhar DK， Yamaguchi E， et al. Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver：possible involvement of COX-2 in the angiogenesis of hepatitis C virus-positive cases[J]. Clin Cancer Res， 2001， 7(5)：1325-1332.
12.	Burns JM， Summers BC， Wang Y， et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival， celladhesion， and tumor development[J]. J Exp Med， 2006， 203(9)：2201-2213.
13.	郑芳，李慧玉，黄士昂. SDF-1/CXCR7轴与肿瘤的研究进展[J]. 肿瘤学杂志， 2010， 16(9)：740-743.
14.	Wang JH， Shiozawa Y， Wang JC， et al. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer[J]. J Biol Chem， 2008， 283(7)：4283-4294.
15.	Miao Z， Luker KE， Summers BC， et al. CXCR7(RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature[J]. Proc Natl Acad Sci U S A， 2007， 104(40)：15735-15740.
16.	Schutyser E， Su Y， Yu Y， et al. Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cells[J]. Eur Cytokine Netw， 2007， 18(2)：59-70.
17.	Goldmann T， Drömann D， Radtke J， et al. CXCR7 transcription in human non-small cell lung cancer and tumor-free lung tissues； possible regulation upon chemotherapy[J]. Virchows Arch， 2008， 452(3)：347-348.
18.	Meijer J， Ogink J， Roos E. Effect of the chemokine receptor CXCR7 on proliferation of carcinoma cells in vitro and in vivo[J]. Br J Cancer， 2008， 99(9)：1493-1501.

1. Raman D， Baugher PJ， Yee MT， et al. Role of chemokines in tumor growth[J]. Cancer Lett， 2007， 256(2)：137-165.
2. Müller A， Homey B， Soto H， et al. Involvement of chemokine receptors in breast cancer metastasis[J]. Nature， 2001， 410(6824)：50-56.
3. Kucia M， Reca R， Miekus K， et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms：pivotal role of the SDF-1-CXCR4 axis[J]. Stem Cells， 2005， 23(7)：879-894.
4. Hartmann TN， Burger JA， Glodek A， et al. CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells[J]. Oncogene， 2005， 24(27)：4462-4471.
5. Libura J， Drukala J， Majka M， et al. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion， chemotaxis， and adhesion[J]. Blood， 2002， 100(7)：2597-2606.
6. 熊斌，王崇树. 趋化因子受体CXCR4和CCR7在甲状腺癌中的表达及其临床病理意义[J]. 中国普外基础与临床杂志， 2011， 18(12)：1301-1304.
7. Iwakiri S， Mino N， Takahashi T， et al. Higher expression of chemokine receptor CXCR7 is linked to early and metastaticrecurrence in pathological stageⅠ nonsmall cell lung cancer[J]. Cancer， 2009， 115(11)：2580-2593.
8. Hattermann K， Held-Feindt J， Lucius R， et al. The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects[J]. Cancer Res， 2010， 70(8)：3299-3308.
9. Zheng K， Li HY， Su XL， et al. Chemokine receptor CXCR7 regulates the invasion， angiogenesis and tumor growth of humanhepatocellular carcinoma cells[J]. J Exp Clin Cancer Res， 2010， 29：31.
10. Singh RK， Lokeshwar BL. The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth[J]. Cancer Res， 2011， 71(9)：3268-3277.
11. Rahman MA， Dhar DK， Yamaguchi E， et al. Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver：possible involvement of COX-2 in the angiogenesis of hepatitis C virus-positive cases[J]. Clin Cancer Res， 2001， 7(5)：1325-1332.
12. Burns JM， Summers BC， Wang Y， et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival， celladhesion， and tumor development[J]. J Exp Med， 2006， 203(9)：2201-2213.
13. 郑芳，李慧玉，黄士昂. SDF-1/CXCR7轴与肿瘤的研究进展[J]. 肿瘤学杂志， 2010， 16(9)：740-743.
14. Wang JH， Shiozawa Y， Wang JC， et al. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer[J]. J Biol Chem， 2008， 283(7)：4283-4294.
15. Miao Z， Luker KE， Summers BC， et al. CXCR7(RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature[J]. Proc Natl Acad Sci U S A， 2007， 104(40)：15735-15740.
16. Schutyser E， Su Y， Yu Y， et al. Hypoxia enhances CXCR4 expression in human microvascular endothelial cells and human melanoma cells[J]. Eur Cytokine Netw， 2007， 18(2)：59-70.
17. Goldmann T， Drömann D， Radtke J， et al. CXCR7 transcription in human non-small cell lung cancer and tumor-free lung tissues； possible regulation upon chemotherapy[J]. Virchows Arch， 2008， 452(3)：347-348.
18. Meijer J， Ogink J， Roos E. Effect of the chemokine receptor CXCR7 on proliferation of carcinoma cells in vitro and in vivo[J]. Br J Cancer， 2008， 99(9)：1493-1501.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Chemokine Receptor CXCR7 in Papillary Thyroid Carcinoma and Its Significance

Abstract Full text Figures/Tables Video References Cited by

Format

Content