Expression and Correlation of XIAP and Survivin in Primary Hepatocellular Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

HOU Ping , JIAN Zhiyuan , ZHANG Min , LAN Haoming

The First General Surgery Department of Taihe Hospital， Hubei University of Medicine， Shiyan 442000， Hubei Province， China;

Corresponding author：

Keywords：

Primary hepatocellular carcinoma; X-linked inhibitor of apoptosis protein; Survivin

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Objective 　To investigate the expressions of X-linked inhibitor of apoptosis protein （XIAP） and survivin in primary hepatocellular carcinoma tissues，and to explore the relationship between them.
Methods 　The expressions of XIAP and survivin protein in 38 primary hepatocellular carcinoma tissues and 16 paracancerous tissues were detected by using immunohistochemistry and the expressions were scored.
Results 　The positive expression rate of XIAP and survivin in primary hepatocellular carcinoma tissues was 81.6% （31/38）and 78.9% （30/38），respctively （P＜0.001）， and in paracancerous tissues was 12.5% （2/16）and 6.3% （1/16）， respectively （P＜0.001）. The score of XIAP expression in the well， middle，and low differentiated tissues of primary hepatocellular carcinoma was （2.91±1.31），（9.27±3.25）， and （13.08±2.26） score， respectively （F=118.948，P＜0.001）， and the score of survivin expression was （4.85±1.83），（11.08±3.72），and （13.38±1.76） score， respectively （F=72.202，P＜0.001）. They both significantly correlated with the histological grade，but not with the size of tumor（P＞0.05）. There was significantly correlation between the expression intensity of XIAP and survivin in primary hepatocellular carcinoma tissues （r=0.764， P＜0.001）.
Conclusions 　The expression intensity of XIAP and survivin in primary hepatocellular carcinoma tissues are both related with the differentiation of primary hepatocellular carcinoma. The expression intensity of XIAP is related with the survivin， and they may play an important role in the tumor progression and chemical resistances.

Citation： HOU Ping,JIAN Zhiyuan,ZHANG Min,LAN Haoming. Expression and Correlation of XIAP and Survivin in Primary Hepatocellular Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(9): 967-970. doi: Copy

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14.	菅志远，张玉环，江斌，等. 胰腺癌中XIAP和Survivin的表达及其相关性[J]. 中国普通外科进展， 2011，12(7)：584-587.
15.	孙德光，吴益峰，高振明，等. 凋亡抑制蛋白PED/PEA-15和XIAP在肝细胞肝癌中的表达及意义[J]. 中华医学杂志， 2010， 90(24)：1660-1664.
16.	Yang Y， Zhu J， Gou H， et al. Clinical significance of Cox-2，Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC) [J]. Med Oncol， 2011， 28(3)：796-803.
17.	郭晓冬，曲建慧，熊璐，等. X连锁凋亡抑制蛋白在肝细胞癌中的表达及其对患者术后复发的影响[J]. 肝脏，2011， 16(3)：206-208.
18.	Wang L， Huang J， Jiang M， et al. Survivin (BIRC5) cell cycle computational network in human no-tumor hepatitis/cirrhosis and hepatocellular carcinoma transformation[J]. J Cell Biochem， 2011， 112(5)：1286-1294.
19.	Hu H， Li Z， Chen J， et al. P16 reactivation induces anoikis and exhibits antitumour potency by downregulating Akt/survivin signalling in hepatocellular carcinoma cells[J] . Gut， 2011， 60(5)：710-721.

1. 樊佳，王征. 原发性肝癌的手术切除[J]. 中华外科杂志， 2010， 48(2)：167-168.
2. Yang L， Cao Z， Yan H， et al. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells：implication for cancer specific therapy[J]. Cancer Res， 2003， 63(2)：6815-6842.
3. Che Y， Ye F， Xu R， et al. Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma[J]. Am J Pathol， 2012， 180(5)：1798-1807.
4. Adamkov M， Kajo K， Vybohova D， et al. Correlations of survivin expression with clinicomorphological parameters and hormonal receptor status in breast ductal carcinoma[J]. Neoplasma， 2012， 59(1)：30-37.
5. Hu W， Wang F， Tang J， et al. Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101[J]. J Biol Chem， 2012， 287(1)：68-80.
6. Messmer UK， Pereda-Fernandez C， Manderscheid M， et al. Dexamethasone inhibits TNF-alpha-induced apoptosis and IAP protein downregulation in MCF-7 cells[J]. Br J Pharmacol， 2001， 133(4)：467-476.
7. Jiang C， Tan T， Yi XP， et al. Lentivirus-mediated shRNA targeting XIAP and survivin inhibit SW1990 pancreatic cancer cell proliferation in vitro and in vivo[J]. Mol Med Report， 2011， 4(4)：667-674.
8. Holt SV， Brookes KE， Dive C， et al. Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents[J] . Oncol Rep， 2011， 25(4)：1177-1181.
9. Hussain AR， Uddin S， Ahmed M， et al. Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling[J]. J Pathol， 2010， 222(2)：180-190.
10. Eckelman BP， Salvesen GS， Scott FL， et al. Human inhibitor of apoptosis proteins：why XIAP is the black sheep of the family[J]. EMBO Rep， 2006， 7(10)：988-994.
11. Mita AC， Mita MM， Nawrocki ST， et al. Survivin：key regulator of mitosis and apoptosis and novel target for cancer therapeutics[J]. Clin Cancer Res， 2008， 14(16)：5000-5005.
12. Hernandez JM， Farma JM， Coppola D， et al. Expression of the antiapoptotic protein survivin in colon cancer[J]. Clin ColorectalCancer， 2011， 10(3)：188-193.
13. Li Y， Jian Z， Xia K， et al. XIAP is related to the chemoresistance and inhibited its expression by RNAi sensitize pancreatic carcinoma cells to chemotherapeutics[J]. Pancreas， 2006， 32(3)：288-296.
14. 菅志远，张玉环，江斌，等. 胰腺癌中XIAP和Survivin的表达及其相关性[J]. 中国普通外科进展， 2011，12(7)：584-587.
15. 孙德光，吴益峰，高振明，等. 凋亡抑制蛋白PED/PEA-15和XIAP在肝细胞肝癌中的表达及意义[J]. 中华医学杂志， 2010， 90(24)：1660-1664.
16. Yang Y， Zhu J， Gou H， et al. Clinical significance of Cox-2，Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC) [J]. Med Oncol， 2011， 28(3)：796-803.
17. 郭晓冬，曲建慧，熊璐，等. X连锁凋亡抑制蛋白在肝细胞癌中的表达及其对患者术后复发的影响[J]. 肝脏，2011， 16(3)：206-208.
18. Wang L， Huang J， Jiang M， et al. Survivin (BIRC5) cell cycle computational network in human no-tumor hepatitis/cirrhosis and hepatocellular carcinoma transformation[J]. J Cell Biochem， 2011， 112(5)：1286-1294.
19. Hu H， Li Z， Chen J， et al. P16 reactivation induces anoikis and exhibits antitumour potency by downregulating Akt/survivin signalling in hepatocellular carcinoma cells[J] . Gut， 2011， 60(5)：710-721.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression and Correlation of XIAP and Survivin in Primary Hepatocellular Carcinoma

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