Application of Octreotide in Treatment for Acute Adhesive Intestinal Obstruction_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI He , XIANG Heping , CHENG Jun.

Department of Emergency Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China;

Corresponding author：

Keywords：

Adhesive intestinal obstruction; Octreotide

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Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo study the effect of octreotide on acute adhesive intestinal obstruction． MethodsFifty-two patients with adhesive intestinal obstruction from January 2009 to January 2011 in this hospital were divided into octreotide treatment group (n=28) and routine treatment group (n=24) according to the treatment methods. Apart from routine treatments, octreotide was administrated in the octreotide treatment group while traditional treatment in the routine treatment group．The effectiveness was observed and compared between two groups. ResultsThe cure rate of the octreotide treatment group was significantly higher than that of the routine treatment group (P lt;0.05). The anus exhausting and defecating time was earlier, hospitalization time was shorter, and gastrointestinal decompression of the treatment octreotide group as compared with the routine treatment group (P lt;0.05)． ConclusionConventional therapy combining with intravenous infusion of octreotide in patients with acute adhesive intestinal obstruction can improve the clinical symptoms and success rate of treatment．

Citation： LI He,XIANG Heping,CHENG Jun.. Application of Octreotide in Treatment for Acute Adhesive Intestinal Obstruction. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(10): 1077-1079. doi: Copy

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1. 吴在德, 吴肇汉. 外科学 [M]. 第7版. 北京: 人民卫生出版社, 2008: 456.
2. 李幼生, 黎介寿．肠梗阻－一个老问题的新思考 [J]. 实用临床医药杂志, 2005, 9(9): 2832.
3. 黎介寿. 改善粘连性小肠梗阻的手术质量 [J]. 中国实用外科杂志, 2000, 20(8): 450452.
4. 吴阶平, 裘法祖. 黄家驷外科学 [M]. 第6版. 北京: 人民卫生出版社, 2000: 10751076.
5. Mercadante S, Ripamonti C, Casuccio A, et al. Comparison of octreotide and hyoscine butylbromide in controlling gastrointestinal symptoms due to malignant inoperable bowel obstruction [J]. Support Care Cancer, 2000, 8(3): 188191.
6. Ripamonti C, Bruera E. Palliative management of malignant bowel obstruction [J]. Int J Gynecol Cancer, 2002, 12(2): 135143.
7. Gtzsche PC, Hróbjartsson A. Somatostatin analogues for acute bleeding oesophageal varices [J]. Cochrane Database Syst Rev, 2008, 16(3): CD000193.
8. Kutun S, Ulucanlar H, Celik A, et al. Effects of octreotide on healing of mechanicalileusin rats [J]. Saudimed J, 2008, 29(4): 539543.
9. Nellgrd P, Boj L, Cassuto J. Importance of vasoactive intestinal peptide and somatostatin for fluid losses in smallbowel obstruction [J]. Scand J Gastroenterol, 1995, 30(5): 464469.
10. Dharmsathaphorn K, Binder HJ, Dobbins JW. Somatostatin stimulates sodium and chloride absorption in the rabbit ileum [J]. Gastroenterology, 1980, 78(6): 15591565.
11. Gong AY, Tietz PS, Muff MA, et al. Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes [J]. Am J Physiol Cell Physiol, 2003, 284(5): C1205C1214.
12. Ripamonti C, Twycross R, Baines M, et al. Clinicalpractice recommendations for the management of bowel obstruction in patients with endstage cancer[J]. Support Care Cancer, 2001, 9(4): 223233.
13. 龚剑峰, 朱维铭, 李宁, 等. 营养支持在术后早期炎性肠梗阻治疗中的应用 [J]. 腹部外科, 2004, 17(4): 209211.
14. 陈雷, 高杰, 王顺福, 等. 生长抑素类似物在急性机械性肠梗阻肿的应用 [J]. 中华普外手术学杂志(电子版), 2009, 3(3): 3032.
15. Tabibian JH. Management of highgrade smallbowel obstruction [J]. Arch Surg, 2010, 145(4): 404405.
16. 任建安, 黎介寿. 粘连性肠梗阻的手术防治 [J]. 中国实用外科杂志, 2008, 28(9): 697699.
17. Maglinte DD, Heitkamp DE, Howard TJ, et al. Current concepts in imaging of small bowel obstruction [J]. Radiol Clin North Am, 2003, 41(2): 263283.
18. 胡孔旺, 朱化刚, 耿小平, 等. 粘连性肠梗阻手术指征多因素分析 [J]. 中国普外基础与临床杂志, 2010, 17(9): 939943.
19. 马广友, 刘延锋. 小肠粘连性肠梗阻术后复发及其影响因素的研究 [J]. 山东医药, 2010, 50(48): 6465.
20. 张毅, 侯勇, 侯昌映, 等. 泛影葡胺胃肠道造影在粘连性肠梗阻中的临床应用 [J]. 中国普外基础与临床杂志, 2006, 13(5): 595596.
21. Fevang BT, Fevang J, Lie SA, et al. Longterm prognosis after operation for adhesive small bowel obstruction [J]. Ann Surg, 2004, 240(2): 193201.
22. 李宁. 重视腹部手术后肠梗阻的非手术治疗 [J]. 中国实用外科杂志, 2008, 28(9): 689691.
23. 王甘露, 侍立志, 贺德, 等. 术后粘连性不完全性肠梗阻的非手术治疗 [J]. 中国普外基础与临床杂志, 2011, 18(3): 286289.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Application of Octreotide in Treatment for Acute Adhesive Intestinal Obstruction

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