Changes of Gastrin and Motilin for Patients with Hepatocellular Carcinoma Complicated with Diabetes Mellitus before and after Operation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LIU Binwei ¹ , LIU Bowei ² , LIU Junru ² , LI Fangning. ³

1.Department of General Surgery, The First Hospital of Qinhuangdao， Hebei Medical University, Qinhuangdao 066000, Hebei Province, China;;
2.Department of Endocrinology, The First Hospital of Qinhuangdao， Qinhuangdao 066000, Hebei Province, China;;
3.Department of Stomatology, The First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, China;

Corresponding author：

Keywords：

Diabetes mellitus; Hepatocellular carcinoma; Gastrin; Motilin

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ObjectiveTo discuss the effects of diabetes mellitus (DM) on gastrointestinal hormone changes before and after hepatocellular carcinoma (HCC) operation. MethodsThe clinical data of 143 patients with HCC treated in this hospital from April 2007 to Febuary 2010 were analyzed, which 43 patients with DM (DM group) and 100 patients without DM (NDM group). Gastrin (GAS) and motilin (MTL) levels were measured on day 3 before operation and on day 1, 2, and 7 after operation. Results① The blood MTL levels decreased and GAS levels increased on day 1, 2, and 7 after operation as compared with the levels before operation (all P lt;0.05). ② The blood MTL level and GAS level before operation in the DM group was higher than that in the NDM group (P lt;0.05), MTL level decreased while GAS level increased more significantly on day 1, 2, and 7 after operation (P lt;0.05). ③ The first anus exhausting time of patients with NDM was much earlier than that with DM (P lt;0.05). ④ The first anus exhausting time with DM over 10 years and fasting plasma glucose over 10 mmo1/L was obviously extended (P lt;0.05). ConclusionDM affectes GAS and MTL level changes after HCC operation, recovery of gastrointestinal function would be delayed if patients with long course of DM and poor control of plasma glucose.

Citation： LIU Binwei,LIU Bowei,LIU Junru,LI Fangning.. Changes of Gastrin and Motilin for Patients with Hepatocellular Carcinoma Complicated with Diabetes Mellitus before and after Operation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(10): 1087-1090. doi: Copy

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8.	王万鹏, 贾德兴, 褚瑞海. 肝炎肝硬化胃动素、胃泌素水平与肝功能损害的关系 [J]. 潍坊医学院学报, 2009, 31(3): 211212．.
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1. Miedema BW, Johnson JO. Methods for decreasing postoperative gut dysmotility [J]. Lancet Oncol, 2003, 4(6): 365372.
2. 中华医学会糖尿病学分会慢性并发症调查组. 1991～2000年全国住院糖尿病患者慢性并发症及相关大血管病变回顾性分析 [J]. 中国医学科学院学报, 2002, 24(5): 447451．.
3. Lovino P, Bilancio G. Gastrointestinal function in simulated space fight microgravity [J]. Dig Liver Dis, 2009, 41(1): 140.
4. Hornbuckle WI, Tennant BC. Gastrointestinal function//Kaneko JJ, Harvey JW, Bruss ML. Clinical Biochemistry of Domestic Animals [M]. Sand Diego: Academic Press, 1997: 367406.
5. 余佩武, 王代科, 文亚渊, 等. 高选择性迷走神经切断加胃窦粘膜切除术对胃泌素和胃排空的影响 [J]. 普外基础与临床杂志, 1995, 2(2)： 7678．.
6. 董军, 张淑文, 王宝恩. 肠功能障碍与多器官功能障碍综合征 [J]. 中国危重病急救医学, 2005, 17(12): 764767．.
7. Luiking YC, Akkermans LM, Van der Reijden AC, et al. Differential effects of motilin on interdigestive motility of the human gastric antrum,pylorus,small intestine and gallbladder [J]. Neurogastroenterol Motil, 2003, 15(2): 103111.
8. 王万鹏, 贾德兴, 褚瑞海. 肝炎肝硬化胃动素、胃泌素水平与肝功能损害的关系 [J]. 潍坊医学院学报, 2009, 31(3): 211212．.
9. Kawagishi T, Nishizawa Y, Okuno Y, et al. Effect of cisapride on gastric emptying of indigestible solids and plasma motilin concentration in diabetic autonomic neuropathy [J]. Am J Gastroenterol, 1993, 88(6): 933938.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Changes of Gastrin and Motilin for Patients with Hepatocellular Carcinoma Complicated with Diabetes Mellitus before and after Operation

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