Clinical Application of Nano-Carbon Particles for Radical Gastrectomy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

CHEN Haining , ZHANG Bo , CHEN Xiufeng , YANG Kun , CHEN Xinzu , HU Jiankun , CHEN Zhixin , CHEN Jiaping.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding author：

Keywords：

Gastric cancer; Nano-carbon particles; Lymph nodes; Radical gastrectomy; Lymphatic tracer

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ObjectiveTo evaluate the lymphatic tracing effects of nano-carbon particles for radical gastrectomy. MethodsTotally eighty-six cases of gastric cancer patients were randomly divided into experimental group (n=43) and control group (n=43). In the experimental group, nanocarbon was injected into the subserosa around the tumor for lymphatic tracing before operation, while no tracer was given in the control group. Then the number of lymph nodes dissected, operation time, and postoperative complications of patients were compared. ResultsThe number of lymph nodes dissected in patients of experimental group was 30.20±11.63 (17-45), which was significantly more than that of control group 〔22.47±7.60 (15-31)〕, P lt;0.05. The blacken rate of lymph nodes in patients of the experimental group was 74.56% (1 260/1 690). Of 302 metastatic lymph nodes, the blacken rate of metastatic lymph nodes was 61.26% (185/302), which was significantly higher than the nonblacken rate of metastatic lymph nodes (38.74%, 117/302), P lt;0.05. The operation time of patients in experimental group 〔(3.51±0.43) h〕 was not different from that in control group 〔(3.49±0.51) h〕, P gt;0.05. The postoperative complications of patients in two groups was not different and no local or systemic adverse reaction occurred in patients of experimental group. ConclusionSubserosal injection of nanocarbon particles around the tumor is safe and can provide the guidance to lymph node dissection in radical gastrectomy.

Citation： CHEN Haining,ZHANG Bo,CHEN Xiufeng,YANG Kun,CHEN Xinzu,HU Jiankun,CHEN Zhixin,CHEN Jiaping.. Clinical Application of Nano-Carbon Particles for Radical Gastrectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(2): 149-152. doi: Copy

1.	田大宇, 胡翔, 袁波. 101例早期胃癌个体化手术治疗的临床分析 [J]. 中国医师进修杂志, 2006, 29(6C): 13.
2.	朱海涛, 赵宜良, 吴云飞, 等. 胃癌各组淋巴结的转移特点及其在实施合理根治术中的指导意义 [J]. 中华肿瘤杂志, 2008, 30(11): 863865.
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4.	黄斌, 李昂, 张波, 等. 纳米炭吸附5FU淋巴靶向化疗对胃癌组织及转移淋巴结bcl2、bax及caspase3表达的影响 [J]. 中国普外基础与临床杂志, 2009, 16(1): 1822.
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10.	Yoshida K, Ohta K, Ohhashi I, et al. Studies on gastric lymphatics by using activated carbon particle (CH44) and lymph node metastasis of gastric cancer [J]. Nippon Geka Gakkai Zasshi, 1988, 89(5): 664670.
11.	谢萍, 谢永美, 宋鑫, 等. 亲水性接枝纳米炭的制备及其淋巴靶向特性的研究 [J]. 华西药学杂志, 2006, 21(4): 337339.
12.	黄广建, 陈忠清, 刘懿, 等. 活性炭纳米粒对胃癌淋巴清扫的指导作用 [J]. 中国现代医学杂志, 2005, 15(2): 233235.
13.	于永扬, 王存, 郑阳春, 等. 比较研究纳米炭示踪剂在低位直肠癌淋巴结清扫及病理检查中的价值 [J]. 中国普外基础与临床杂志, 2008, 15(5): 358361.
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16.	曲秋莲, 张英鸽, 杨留中, 等. 纳米活性炭吸附丝裂霉素C腹腔化疗的实验研究 [J]. 中华肿瘤杂志, 2006, 28(4): 257260.
17.	李伟, 徐亮. 纳米炭在胃癌淋巴靶向化疗中的应用研究进展 [J]. 泸州医学院学报, 2009, 32(4): 439441.
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19.	季加孚. 胃癌外科的现状与发展趋势 [J]. 中国普外基础与临床杂志, 2006, 13(1): 13.
20.	贺岭风, 杨克虎, 田金徽, 等. 胃癌新辅助化疗疗效的系统评价-Meta分析 [J]. 癌症, 2008, 27(4): 407412.
21.	Kim HH, Hyung WJ, Cho GS, et al. Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report-a phase Ⅲ multicenter, prospective, randomized Trial (KLASS Trial) [J]. Ann Surg, 2010, 251(3): 417420.
22.	Chen XZ, Hu JK, Yang K, et al. Shortterm evaluation of laparoscopyassisted distal gastrectomy for predictive early gastric cancer: a metaanalysis of randomized controlled trials [J]. Surg Laparosc Endosc Percutan Tech, 2009, 19(4): 277284.
23.	Sano T, Hollowood A. Early gastric cancer: diagnosis and less invasive treatments [J]. Scand J Surg, 2006, 95(4): 249255.
24.	吴星宇, 席时富. 胃癌病理学的变化及其与外科治疗的关系 [J]. 现代医学, 2004, 32(6): 399400.
25.	Songun I, van de Velde CJ. Optimal surgery for advanced gastric cancer [J]. Expert Rev Anticancer Ther, 2009, 9(12): 18491858.

1. 田大宇, 胡翔, 袁波. 101例早期胃癌个体化手术治疗的临床分析 [J]. 中国医师进修杂志, 2006, 29(6C): 13.
2. 朱海涛, 赵宜良, 吴云飞, 等. 胃癌各组淋巴结的转移特点及其在实施合理根治术中的指导意义 [J]. 中华肿瘤杂志, 2008, 30(11): 863865.
3. Saito H, Tsujitani S, Oka S, et al. Prediction of survival period for patients with postoperative recurrence after curative resection for advanced gastric carcinoma [J]. Hepatogastroenterology, 2001, 48(37): 290293.
4. 黄斌, 李昂, 张波, 等. 纳米炭吸附5FU淋巴靶向化疗对胃癌组织及转移淋巴结bcl2、bax及caspase3表达的影响 [J]. 中国普外基础与临床杂志, 2009, 16(1): 1822.
5. 所剑. 胃癌的淋巴结清扫及意义 [J]. 中国普外基础与临床杂志, 2010, 17(1): 57.
6. 胡祥. 日本《胃癌治疗指南》(第3版)解读 [J]. 中国实用外科杂志, 2010, 30(1): 2530.
7. 陈峻青. 胃癌外科治疗几个问题的新进展 [J]. 中国普外基础与临床杂志, 2010, 17(1): 14.
8. Okamoto K, Sawai K, Minato H, et al. Number and anatomical extent of lymph node metastases in gastric cancer: analysis using intralymph node injection of activated carbon particles (CH40) [J]. Jpn J Clin Oncol, 1999, 29(2): 7477.
9. 苏向前, 邢加迪. 示踪技术在胃癌诊治中的应用 [J]. 中国实用外科杂志, 2005, 25(7): 392394.
10. Yoshida K, Ohta K, Ohhashi I, et al. Studies on gastric lymphatics by using activated carbon particle (CH44) and lymph node metastasis of gastric cancer [J]. Nippon Geka Gakkai Zasshi, 1988, 89(5): 664670.
11. 谢萍, 谢永美, 宋鑫, 等. 亲水性接枝纳米炭的制备及其淋巴靶向特性的研究 [J]. 华西药学杂志, 2006, 21(4): 337339.
12. 黄广建, 陈忠清, 刘懿, 等. 活性炭纳米粒对胃癌淋巴清扫的指导作用 [J]. 中国现代医学杂志, 2005, 15(2): 233235.
13. 于永扬, 王存, 郑阳春, 等. 比较研究纳米炭示踪剂在低位直肠癌淋巴结清扫及病理检查中的价值 [J]. 中国普外基础与临床杂志, 2008, 15(5): 358361.
14. 瞿欢, 张亚男, 陈卫东. 纳米炭在乳腺癌前哨淋巴结示踪的实验研究 [J]. 中国普通外科杂志, 2010, 19(5): 489492.
15. 范新, 陈卫东, 汤文浩, 等. 纳米炭示踪胃癌前哨淋巴结的实验研究 [J]. 东南大学学报(医学版), 2010, 29(3): 287290.
16. 曲秋莲, 张英鸽, 杨留中, 等. 纳米活性炭吸附丝裂霉素C腹腔化疗的实验研究 [J]. 中华肿瘤杂志, 2006, 28(4): 257260.
17. 李伟, 徐亮. 纳米炭在胃癌淋巴靶向化疗中的应用研究进展 [J]. 泸州医学院学报, 2009, 32(4): 439441.
18. 张海燕, 孙立波. 胃癌术前分期诊断的研究进展 [J]. 中国普外基础与临床杂志, 2010, 17(1): 3436.
19. 季加孚. 胃癌外科的现状与发展趋势 [J]. 中国普外基础与临床杂志, 2006, 13(1): 13.
20. 贺岭风, 杨克虎, 田金徽, 等. 胃癌新辅助化疗疗效的系统评价-Meta分析 [J]. 癌症, 2008, 27(4): 407412.
21. Kim HH, Hyung WJ, Cho GS, et al. Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report-a phase Ⅲ multicenter, prospective, randomized Trial (KLASS Trial) [J]. Ann Surg, 2010, 251(3): 417420.
22. Chen XZ, Hu JK, Yang K, et al. Shortterm evaluation of laparoscopyassisted distal gastrectomy for predictive early gastric cancer: a metaanalysis of randomized controlled trials [J]. Surg Laparosc Endosc Percutan Tech, 2009, 19(4): 277284.
23. Sano T, Hollowood A. Early gastric cancer: diagnosis and less invasive treatments [J]. Scand J Surg, 2006, 95(4): 249255.
24. 吴星宇, 席时富. 胃癌病理学的变化及其与外科治疗的关系 [J]. 现代医学, 2004, 32(6): 399400.
25. Songun I, van de Velde CJ. Optimal surgery for advanced gastric cancer [J]. Expert Rev Anticancer Ther, 2009, 9(12): 18491858.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Application of Nano-Carbon Particles for Radical Gastrectomy

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