Neck Lymph Node Metastasis and Related Factors in Thyroiditis Coexisting Thyroid Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Guang , ZHANG Chunhai , FU Yantao , BIAN Xuehai , SUN Hui.

Department of Thyroid Surgery, ChinaJapan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China;

Corresponding author：

Keywords：

Thyroiditis; Thyroid cancer; Lymph node; Metastasis

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo investigate the condition of neck lymph node metastasis and related factors in thyroiditis coexisting thyroid cancer, and make clear the indication of neck lymph node dissection. MethodsA retrospective cohort study was conducted with the clinical data of 147 patients with thyroiditis coexisting thyroid cancer who underwent radical resection of thyroid cancer (total thyroidectomy or subtotal thyroidectomy) and neck lymph node dissection, including age, gender, tumor size, number of focuses, and lymph node metastasis. Results Among 147 patients, 65 patients with neck lymph node metastasis (44.22%), central cervical lymph node metastasis rate was 36.05% （53/147）， which was higher than that of lateral lymph node metastasis rate (20.41%, 30/147), P lt;0.05. Neck lymph node metastasis rate was correlated with patient’s gender and tumor size （P lt;0.05）, while it was not correlated with patient’s age and number of focuses (P gt;0.05). ConclusionCentral neck lymph node metastasis rate is higher in patients with thyroiditis coexisting thyroid cancer, then routine prophylactic central neck lymph node dissection is significant. Patient’s gender and tumor size are correlated with neck lymph node metastasis. When tumor is larger or in male, ipsilateral lymph node dissection should be considered to done.

Citation： ZHANG Guang,ZHANG Chunhai,FU Yantao,BIAN Xuehai,SUN Hui.. Neck Lymph Node Metastasis and Related Factors in Thyroiditis Coexisting Thyroid Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(6): 625-628. doi: Copy

1.	Shindo M, Wu JC, Park EE, et al. The importance of central compartment elective lymph node excision in the staging and treatment of papillary thyroid cancer [J]. Arch Otolaryngol Head Neck Surg, 2006, 132(6): 650654.
2.	周春阳, 王德尚, 金华芬, 等. 桥本甲状腺炎合并甲状腺乳头状癌20例病理分析 [J]. 现代实用医学, 2009, 21(12): 13031304.
3.	McKee RF, Krukowski ZH, Matheson NA. Thyroid neoplasia coexistent with chronic lymphocytic thyroiditis [J]. Br J Surg, 1993, 80(10): 13031304.
4.	孙源. 桥本氏甲状腺肿合并甲状腺癌的治疗分析(附32例报告) [J]. 医学理论与实践， 2008， 21(6): 669670.
5.	Dionigi G, Dionigi R, Bartalena L, et al. Surgery of lymph nodes in papillary thyroid cancer [J]. Expert Rev Anticancer Ther, 2006, 6（9）: 12171229.
6.	Mc Gregor GI, Luoma A, Jackson SM. Lymph node metastases from well differentiated thyroid cancer [J]. Am J Surg, 1985, 149(5): 610612.
7.	Sato N, Oyamatsu M, Koyama Y, et al. Do the level of nodal disease according to the TNM classification and the number of involved cervical nodes reflect prognosis in patients with differentiated carcinoma of the thyroid gland? [J]. J Surg Oncol, 1998, 69(3): 151155.
8.	刘跃武，高维生，唐伟松. 应更好地规范甲状腺癌的初次手术 [J]. 中国普外基础与临床杂志, 2006, 13(3): 254255.
9.	Mathonnet M. Lymph node dissection in nonmedullary differentiated thyroid carcinoma [J]. Ann Chir, 2006, 131（67）: 361368.
10.	Melliere D, Hindie E, Becquemin JP, et al. Differentiated thyroid carcinomahow to improve the longterm results? Twentyfiveyear outcomes of 850 patients [J].Bull Acad Natl Med, 2006, 190(1): 89109.
11.	Ito Y, Tomoda C, Uruno T, et al. Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid [J]. World J Surg, 2006, 30(1): 9199.
12.	李日增，周宏，潘黎静. 甲状腺微小癌预后因素分析 [J]. 实用医学杂志, 2009, 25(21): 36533655.
13.	Caron NR, Clark OH. Papillary thyroid cancer: surgical management of lymph node metastases [J]. Curr Treat Options Oncol, 2005, 6(4): 311322.
14.	Machens A, Holzhausen HJ, Dralle H. The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma [J]. Cancer, 2005, 103(11): 22692273.
15.	Roti E， Rsssi R， Trasforini G， et al. Clinical and histological characteristics of papillary thyroid microcarcinoma： results of a retrospective study in 243 patients [J]. J Clin Endocrinol Metab， 2006， 91（6）： 21712178.
16.	刘永峰. 加强分化型甲状腺癌的规范化治疗 [J]. 中国普外基础与临床杂志, 2009, 16(5): 341343.
17.	Del Rio P, Cataldo S, Sommaruga L， et al. The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer? [J]. Minerva Endocrinologica, 2008, 33(1): 15.

1. Shindo M, Wu JC, Park EE, et al. The importance of central compartment elective lymph node excision in the staging and treatment of papillary thyroid cancer [J]. Arch Otolaryngol Head Neck Surg, 2006, 132(6): 650654.
2. 周春阳, 王德尚, 金华芬, 等. 桥本甲状腺炎合并甲状腺乳头状癌20例病理分析 [J]. 现代实用医学, 2009, 21(12): 13031304.
3. McKee RF, Krukowski ZH, Matheson NA. Thyroid neoplasia coexistent with chronic lymphocytic thyroiditis [J]. Br J Surg, 1993, 80(10): 13031304.
4. 孙源. 桥本氏甲状腺肿合并甲状腺癌的治疗分析(附32例报告) [J]. 医学理论与实践， 2008， 21(6): 669670.
5. Dionigi G, Dionigi R, Bartalena L, et al. Surgery of lymph nodes in papillary thyroid cancer [J]. Expert Rev Anticancer Ther, 2006, 6（9）: 12171229.
6. Mc Gregor GI, Luoma A, Jackson SM. Lymph node metastases from well differentiated thyroid cancer [J]. Am J Surg, 1985, 149(5): 610612.
7. Sato N, Oyamatsu M, Koyama Y, et al. Do the level of nodal disease according to the TNM classification and the number of involved cervical nodes reflect prognosis in patients with differentiated carcinoma of the thyroid gland? [J]. J Surg Oncol, 1998, 69(3): 151155.
8. 刘跃武，高维生，唐伟松. 应更好地规范甲状腺癌的初次手术 [J]. 中国普外基础与临床杂志, 2006, 13(3): 254255.
9. Mathonnet M. Lymph node dissection in nonmedullary differentiated thyroid carcinoma [J]. Ann Chir, 2006, 131（67）: 361368.
10. Melliere D, Hindie E, Becquemin JP, et al. Differentiated thyroid carcinomahow to improve the longterm results? Twentyfiveyear outcomes of 850 patients [J].Bull Acad Natl Med, 2006, 190(1): 89109.
11. Ito Y, Tomoda C, Uruno T, et al. Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid [J]. World J Surg, 2006, 30(1): 9199.
12. 李日增，周宏，潘黎静. 甲状腺微小癌预后因素分析 [J]. 实用医学杂志, 2009, 25(21): 36533655.
13. Caron NR, Clark OH. Papillary thyroid cancer: surgical management of lymph node metastases [J]. Curr Treat Options Oncol, 2005, 6(4): 311322.
14. Machens A, Holzhausen HJ, Dralle H. The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma [J]. Cancer, 2005, 103(11): 22692273.
15. Roti E， Rsssi R， Trasforini G， et al. Clinical and histological characteristics of papillary thyroid microcarcinoma： results of a retrospective study in 243 patients [J]. J Clin Endocrinol Metab， 2006， 91（6）： 21712178.
16. 刘永峰. 加强分化型甲状腺癌的规范化治疗 [J]. 中国普外基础与临床杂志, 2009, 16(5): 341343.
17. Del Rio P, Cataldo S, Sommaruga L， et al. The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer? [J]. Minerva Endocrinologica, 2008, 33(1): 15.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Neck Lymph Node Metastasis and Related Factors in Thyroiditis Coexisting Thyroid Cancer

Abstract Full text Figures/Tables Video References Cited by

Format

Content