Expressions of Galectin-3 and CD105 Protein in Colorectal Cancer and Their Significances_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Hongwei ¹ , LI Yanhong ² , HUANG Yong ¹ , ZHANG Hai ¹ , WANG Tieshan ¹ , HU Haixia ¹ , XIONG Zhengwen. ¹

1.Department of Pathology, PLA 251th Hospital, Zhangjiakou 075000, Hebei Province, China;;
2.Department of Medical Insurance Office, PLA 261th Hospital, Beijing 100094, China;

Corresponding author：

Keywords：

Galectin-3 protein; CD105 protein; Microvessel density; Colorectal cancer; Immunohistochemistry

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo explore the expressions of galectin-3 protein and CD105 protein in colorectal cancer and the relationship with clinicopathologic features. MethodsThe expressions of galectin-3 protein and CD105 protein 〔microvessel density (MVD)〕 were detected in 60 cases of colorectal cancer tissues, 30 cases of adenoma tissues, and 30 cases of normal mucosa tissues (at least 4 cm far from carcinoma) by MicrowaveEliVisionTM immunohistochemistry, and the relationship with clinicopathologic features was analyzed. ResultsThe expressions of galectin3 protein and MVD in normal mucosa tissues, adenoma tissues, and cancer tissues gradually increased (P lt;0.05). The expression of galectin-3 protein and MVD in colorectal cancer tissues were correlated to TNM stage, invasive depth, and lymph node metastasis (P lt;0.05， P lt;0.01), and the expression of glectin-3 protein was also correlated to differentiated degree (P lt;0.05). The expression of galectin-3 protein in colorectal cancer tissues was positively correlated to MVD (r=0.420， P lt;0.01). ConclusionsThe high expressions of galectin-3 protein and CD105 protein are correlated to the high invasion ability and lymph node metastasis, which may be potential sensitive index to predict the invasion and metastasis of colorectal cancer.

Citation： LI Hongwei,LI Yanhong,HUANG Yong,ZHANG Hai,WANG Tieshan,HU Haixia,XIONG Zhengwen.. Expressions of Galectin-3 and CD105 Protein in Colorectal Cancer and Their Significances. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(8): 871-875. doi: Copy

1.	Hirakawa S, Hong YK, Harvey N, et al. Identification of vascular lineagespecific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells [J]. Am J Pathol, 2003, 162(2): 575586.
2.	李颖, 陈平, 段世刚. CD105 mRNA在原发性肝细胞癌的表达与术后复发的关系 [J]. 中华消化外科杂志, 2007, 6(1): 4851.
3.	Ellerhorst JA, Stephens LC, Nguyen T, et al. Effects of galectin3 expression on growth and tumorigenicity of the prostate cancer cell line LNCaP [J]. Prostate, 2002, 50(1): 6470.
4.	Castronovo V, Van Den Brle FA, Jackers P, et al. Decreased expression of galectin3 is associated with progression of human breast cancer [J]. J Pathol, 1996, 179(1): 4348.
5.	van den Brule FA, Buicu C, Berchuck A, et al. Expression of the 67kD laminin receptor, galectin1, and galectin3 in advanced human uterine adenocarcinoma [J]. Hum Pathol, 1996, 27(11): 11851191.
6.	虞积耀, 崔全才主译. Hamilton SR, Aaltonen LA著. 世界卫生组织肿瘤分类及诊断标准系列：消化系统肿瘤病理学和遗传学 [M]. 北京: 人民卫生出版社, 2006: 122131.
7.	熊正文. 免疫组织化学技术中抗原修复的研究进展 [J]. 中华病理学杂志, 1997, 26(2): 124126.
8.	许良中，杨文涛．免疫组织化学反应结果的判断标准 [J]．中国癌症杂志， 1996， 6（4）： 229231.
9.	Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in earlystage breast carcinoma [J]. J Natl Cancer Inst, 1992, 84(24): 18751887.
10.	Szke T, Kayser K, Trojan I, et al. The role of microvascularization and growth/adhesionregulatory lectins in the prognosis of nonsmall cell lung cancer in stage Ⅱ [J]. Eur J Cardiothorac Surg, 2007, 31(5): 783787.
11.	Miyazaki J, Hokari R, Kato S, et al. Increased expression of galectin3 in primary gastric cancer and the metastatic lymph nodes [J]. Oncol Rep, 2002, 9(6): 13071312.
12.	杨志明, 伍晓汀, 何涛, 等. 胃癌腹膜转移中galectin3 mRNA的表达与意义 [J]. 四川大学学报(医学版), 2006, 37(1): 105108.
13.	Ulmer TA, Keeler V, Loh L, et al. Tumorassociated antigen 90K/Mac2binding protein: possible role in colon cancer [J]. J Cell Biochem, 2006, 98(5): 13511366.
14.	Folkman J, Klagsbrun M. Angiogenic factors [J]. Science, 1987, 235(4787): 442447.
15.	张江宇，王颀，朱彩霞，等． CD105在乳腺癌发生发展过程中表达的研究 [J]．中华肿瘤防治杂志， 2007， 14（19）： 14721474．.
16.	Wang X, Hershman DL, Abrams JA, et al. Predictors of survival after hepatic resection among patients with colorectal liver metastasis [J]. Br J Cancer, 2007, 97(12): 16061612.
17.	牛保华，皇甫超申，赵卫． CD105及微血管密度与胃癌的关系 [J]．河南大学学报(医学版)， 2008， 27（2）： 2425．.
18.	Wang JM, Kumar S, Pye D, et al. A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues [J]. Int J Cancer, 1993, 54(3): 363370.
19.	Kumar P, Wang JM, Bernabeu C. CD105 and angiogenesis [J]. J Pathol, 1996, 178(4): 363366.
20.	张英辉，陈素琴．肿瘤血管标志物CD105的研究及应用进展 [J]．医学综述， 2009， 15（1）： 6870.
21.	姚永忠，潘一明，孙喜太，等．血管新生过程中CD105的表达变化及其作用 [J]．中国普外基础与临床杂志， 2009， 16（10）： 824829.
22.	韩玉贞，吕增华，朱玉红，等． Galectin3 VEGF Ki67 MVD在青年乳腺癌淋巴结转移灶中的表达及意义 [J]．中国肿瘤临床， 2008， 35（15）： 874876.

1. Hirakawa S, Hong YK, Harvey N, et al. Identification of vascular lineagespecific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells [J]. Am J Pathol, 2003, 162(2): 575586.
2. 李颖, 陈平, 段世刚. CD105 mRNA在原发性肝细胞癌的表达与术后复发的关系 [J]. 中华消化外科杂志, 2007, 6(1): 4851.
3. Ellerhorst JA, Stephens LC, Nguyen T, et al. Effects of galectin3 expression on growth and tumorigenicity of the prostate cancer cell line LNCaP [J]. Prostate, 2002, 50(1): 6470.
4. Castronovo V, Van Den Brle FA, Jackers P, et al. Decreased expression of galectin3 is associated with progression of human breast cancer [J]. J Pathol, 1996, 179(1): 4348.
5. van den Brule FA, Buicu C, Berchuck A, et al. Expression of the 67kD laminin receptor, galectin1, and galectin3 in advanced human uterine adenocarcinoma [J]. Hum Pathol, 1996, 27(11): 11851191.
6. 虞积耀, 崔全才主译. Hamilton SR, Aaltonen LA著. 世界卫生组织肿瘤分类及诊断标准系列：消化系统肿瘤病理学和遗传学 [M]. 北京: 人民卫生出版社, 2006: 122131.
7. 熊正文. 免疫组织化学技术中抗原修复的研究进展 [J]. 中华病理学杂志, 1997, 26(2): 124126.
8. 许良中，杨文涛．免疫组织化学反应结果的判断标准 [J]．中国癌症杂志， 1996， 6（4）： 229231.
9. Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in earlystage breast carcinoma [J]. J Natl Cancer Inst, 1992, 84(24): 18751887.
10. Szke T, Kayser K, Trojan I, et al. The role of microvascularization and growth/adhesionregulatory lectins in the prognosis of nonsmall cell lung cancer in stage Ⅱ [J]. Eur J Cardiothorac Surg, 2007, 31(5): 783787.
11. Miyazaki J, Hokari R, Kato S, et al. Increased expression of galectin3 in primary gastric cancer and the metastatic lymph nodes [J]. Oncol Rep, 2002, 9(6): 13071312.
12. 杨志明, 伍晓汀, 何涛, 等. 胃癌腹膜转移中galectin3 mRNA的表达与意义 [J]. 四川大学学报(医学版), 2006, 37(1): 105108.
13. Ulmer TA, Keeler V, Loh L, et al. Tumorassociated antigen 90K/Mac2binding protein: possible role in colon cancer [J]. J Cell Biochem, 2006, 98(5): 13511366.
14. Folkman J, Klagsbrun M. Angiogenic factors [J]. Science, 1987, 235(4787): 442447.
15. 张江宇，王颀，朱彩霞，等． CD105在乳腺癌发生发展过程中表达的研究 [J]．中华肿瘤防治杂志， 2007， 14（19）： 14721474．.
16. Wang X, Hershman DL, Abrams JA, et al. Predictors of survival after hepatic resection among patients with colorectal liver metastasis [J]. Br J Cancer, 2007, 97(12): 16061612.
17. 牛保华，皇甫超申，赵卫． CD105及微血管密度与胃癌的关系 [J]．河南大学学报(医学版)， 2008， 27（2）： 2425．.
18. Wang JM, Kumar S, Pye D, et al. A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues [J]. Int J Cancer, 1993, 54(3): 363370.
19. Kumar P, Wang JM, Bernabeu C. CD105 and angiogenesis [J]. J Pathol, 1996, 178(4): 363366.
20. 张英辉，陈素琴．肿瘤血管标志物CD105的研究及应用进展 [J]．医学综述， 2009， 15（1）： 6870.
21. 姚永忠，潘一明，孙喜太，等．血管新生过程中CD105的表达变化及其作用 [J]．中国普外基础与临床杂志， 2009， 16（10）： 824829.
22. 韩玉贞，吕增华，朱玉红，等． Galectin3 VEGF Ki67 MVD在青年乳腺癌淋巴结转移灶中的表达及意义 [J]．中国肿瘤临床， 2008， 35（15）： 874876.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expressions of Galectin-3 and CD105 Protein in Colorectal Cancer and Their Significances

Abstract Full text Figures/Tables Video References Cited by

Format

Content