Effects of Edaravone on Lung Injury of Severe Acute Pancreatitis in Rats_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHOU Lin , LIANG Daoming , CHEN Jiayong , GAN Ping , ZHANG Jiahua

Department of General Surgery, The Second Affiliated Hospital of Kunming Medical College, Kunming 650101， China;

Corresponding author：

Keywords：

Edaravone; Severe acute pancreatitis; Lung injury; Rat

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Objective To study the effects of edaravone on the lung injury of severe acute pancreatitis （SAP） in rats. Methods Thirty-six SD rats were randomly divided into three groups: normal control group, model group and edaravone group, and SAP was induced by intraductal administration of 5% sodium taurocholate. Edaravone was given in edaravone group, while normal saline was given in normal control group and model group. After operation 6 h rats were executed, and dry/wet weight (D/W) ratio of lung was counted, and malondialdehyde (MDA) content, superoxide dismutase (SOD) activity in serum and lung were detected, respectively. In addition, the levels of tumor necrosis factor-α (TNF-α), interleukin-1, -6 (IL-1, -6) of serum were detected.
Results The MDA contentof serum and lung and the levels of TNF-α, IL-1, IL-6 in model group were markedly higher than those in normal control group and edaravone group, but D/W ratio of lung, SOD activity of serum and lung were significantly lower (P lt;0.05).
Conclusion Edaravone can alleviate lung injury of rats caused by SAP.

Citation： ZHOU Lin,LIANG Daoming,CHEN Jiayong,GAN Ping,ZHANG Jiahua. Effects of Edaravone on Lung Injury of Severe Acute Pancreatitis in Rats. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(2): 152-155. doi: Copy

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2.	Yang YL, Li JP, Li KZ, et al. Tumor necrosis factor alpha antibody prevents brain damage of rats with acute necrotizing pancreatitis [J]. World J Gastroenterol， 2004； 10(19): 28982900.
3.	Granger J, Remick D. Acute pancreatitis: models markers, and mediators [J]. Shock, 2005； 24(Suppl 1): 4551.
4.	Norman JG, Fink GW, Messina J, et al. Timing of tumor necrosis factor antagonism is critical in determining outcome in murine lethal acute pancreatitis [J]. Surgery, 1996； 120(3): 515521.
5.	薛东波, 王海洋, 张伟辉. 急性胰腺炎大鼠核因子κB、TNFα 及胰腺病理损伤的动态变化 [J]. 中国现代医学杂志, 2005; 15(10): 15121514.
6.	Malleo G, Mazzon E, Siriwardena AK, et al. TNFalpha as a therapeutic target in acute pancreastitis-lessons from experimental models [J]. Scientific World J, 2007； 30(7): 431438.
7.	Gultekin FA, Kerem M, Tatlicoglu E, et al. Leptin treatment ameliorates acute lung in rats with ceruleaninduced acute pancreastitis [J]. World J Gastroenterol, 2007； 13(21): 29322938.
8.	Satoh M, Kashihara N, Fujimoto S, et al. A novel free radical scavenger， edarabone, protects against ciaplatininduced acute renal damage in vitro and in vivo [J]. J Pharmacol Exp Ther, 2003； 305(3): 11831190.
9.	蔡志友, 晏勇, 张骏, 等. 依达拉奉对血管性认知功能损害大鼠IL1β、TNFα与VEGF表达的影响 [J]. 重庆医科大学学报, 2009; 34（1）: 6670.
10.	王小红, 沈云志, 黄中伟. 依达拉奉对重症急性胰腺炎大鼠脑损伤保护作用的试验研究 [J]. 新医学, 2009; 40（6）: 361365.
11.	林峥, 李兴旺, 刘中砥. 依达拉奉对肠部分缺血再灌注损伤大鼠肠组织TNFα和IL6的影响 [J]. 江西医药, 2008; 43（4）: 298300.
12.	邹俊, 张中军. 依达拉奉预给药对缺血再灌注损伤大鼠心肌梗死范围及血中TNFα、IL1β的影响 [J]. 中国微循环, 2008; 12（5）: 287289.
13.	石凤玲. 依达拉奉治疗急性脑出血的临床观察 [J]. 齐齐哈尔医学院学报, 2009; 30(12): 14651466.
14.	赵序元, 孟祥德, 李胜军, 等. 依达拉奉对大鼠脑外伤后细胞凋亡率及Bcl2／Bax表达的影响 [J]. 临床神经外科杂志, 2009; 5(2): 7678.
15.	单若莹, 张艳华, 朱艳玲, 等. 依达拉奉治疗急性脑梗死临床观察 [J]. 中国实用神经疾病杂志， 2009; 12(10): 47.
16.	董凌琳, 郭富强, 杨友松, 等. 自由基清除剂依达拉奉对大鼠脑出血的治疗作用 [J]. 中华神经科杂志, 2007; 40(1): 5053.
17.	曹士奇, 陈明智, 刘尊涛. 依达拉奉与抑肽酶对兔急性肺损伤的保护作用比较 [J]. 江苏大学学报（医学版）， 2008; 18(5): 413415.
18.	Ito K, Ozasa H, Horikawa S, Horikawa S. Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat [J]. Free Radical Biol Med, 2005； 38(3): 369374.
19.	潘佳容, 肖志辉. 依达拉奉对新生鼠高氧肺损伤的影响 [J]. 中国实用儿科杂志, 2007； 22(1): 4951.
20.	Nakamoto N, Tada S, Kameyama K, et al. A free radical scavenger, edalavone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury [J]. Free Radical Res, 2003； 37(8): 849859.
21.	Tsuji K, Kwon AH, Yoshida H, et al. Free radical scavenger (edalavone) prevents endotoxininduced liver injury after partilhepatectomy in rats [J]. J Hepatol, 2005； 42(1): 94101.
22.	张中军, 邹俊, 丁娴, 等. 依达拉奉对大鼠烧伤休克性急性肺损伤的保护作用 [J]. 江苏医药, 2009; 35（5）: 547548.
23.	邢海波, 李刚, 徐亚平, 等. 依达拉奉对脓毒症大鼠肺损伤的保护作用 [J]. 中国呼吸与危重监护杂志, 2009; 8（2）: 176180.
24.	尤再春, 史忠, 高全杰, 等. 依达拉奉对百草枯中毒致急性肺损伤预防及治疗作用研究 [J]. 重庆医学, 2008; 37（22）: 25172519.
25.	张卓一, 徐秋萍. 依达拉奉在急性肺损伤大鼠中的抗氧自由基作用 [J]. 浙江医学, 2007; 29（6）: 542544.

1. Andrulli A, Perri F, Annese V. Guidelines for treatment of acute pancreatitis [J]. Gut, 1999; 44(4): 579580.
2. Yang YL, Li JP, Li KZ, et al. Tumor necrosis factor alpha antibody prevents brain damage of rats with acute necrotizing pancreatitis [J]. World J Gastroenterol， 2004； 10(19): 28982900.
3. Granger J, Remick D. Acute pancreatitis: models markers, and mediators [J]. Shock, 2005； 24(Suppl 1): 4551.
4. Norman JG, Fink GW, Messina J, et al. Timing of tumor necrosis factor antagonism is critical in determining outcome in murine lethal acute pancreatitis [J]. Surgery, 1996； 120(3): 515521.
5. 薛东波, 王海洋, 张伟辉. 急性胰腺炎大鼠核因子κB、TNFα 及胰腺病理损伤的动态变化 [J]. 中国现代医学杂志, 2005; 15(10): 15121514.
6. Malleo G, Mazzon E, Siriwardena AK, et al. TNFalpha as a therapeutic target in acute pancreastitis-lessons from experimental models [J]. Scientific World J, 2007； 30(7): 431438.
7. Gultekin FA, Kerem M, Tatlicoglu E, et al. Leptin treatment ameliorates acute lung in rats with ceruleaninduced acute pancreastitis [J]. World J Gastroenterol, 2007； 13(21): 29322938.
8. Satoh M, Kashihara N, Fujimoto S, et al. A novel free radical scavenger， edarabone, protects against ciaplatininduced acute renal damage in vitro and in vivo [J]. J Pharmacol Exp Ther, 2003； 305(3): 11831190.
9. 蔡志友, 晏勇, 张骏, 等. 依达拉奉对血管性认知功能损害大鼠IL1β、TNFα与VEGF表达的影响 [J]. 重庆医科大学学报, 2009; 34（1）: 6670.
10. 王小红, 沈云志, 黄中伟. 依达拉奉对重症急性胰腺炎大鼠脑损伤保护作用的试验研究 [J]. 新医学, 2009; 40（6）: 361365.
11. 林峥, 李兴旺, 刘中砥. 依达拉奉对肠部分缺血再灌注损伤大鼠肠组织TNFα和IL6的影响 [J]. 江西医药, 2008; 43（4）: 298300.
12. 邹俊, 张中军. 依达拉奉预给药对缺血再灌注损伤大鼠心肌梗死范围及血中TNFα、IL1β的影响 [J]. 中国微循环, 2008; 12（5）: 287289.
13. 石凤玲. 依达拉奉治疗急性脑出血的临床观察 [J]. 齐齐哈尔医学院学报, 2009; 30(12): 14651466.
14. 赵序元, 孟祥德, 李胜军, 等. 依达拉奉对大鼠脑外伤后细胞凋亡率及Bcl2／Bax表达的影响 [J]. 临床神经外科杂志, 2009; 5(2): 7678.
15. 单若莹, 张艳华, 朱艳玲, 等. 依达拉奉治疗急性脑梗死临床观察 [J]. 中国实用神经疾病杂志， 2009; 12(10): 47.
16. 董凌琳, 郭富强, 杨友松, 等. 自由基清除剂依达拉奉对大鼠脑出血的治疗作用 [J]. 中华神经科杂志, 2007; 40(1): 5053.
17. 曹士奇, 陈明智, 刘尊涛. 依达拉奉与抑肽酶对兔急性肺损伤的保护作用比较 [J]. 江苏大学学报（医学版）， 2008; 18(5): 413415.
18. Ito K, Ozasa H, Horikawa S, Horikawa S. Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat [J]. Free Radical Biol Med, 2005； 38(3): 369374.
19. 潘佳容, 肖志辉. 依达拉奉对新生鼠高氧肺损伤的影响 [J]. 中国实用儿科杂志, 2007； 22(1): 4951.
20. Nakamoto N, Tada S, Kameyama K, et al. A free radical scavenger, edalavone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury [J]. Free Radical Res, 2003； 37(8): 849859.
21. Tsuji K, Kwon AH, Yoshida H, et al. Free radical scavenger (edalavone) prevents endotoxininduced liver injury after partilhepatectomy in rats [J]. J Hepatol, 2005； 42(1): 94101.
22. 张中军, 邹俊, 丁娴, 等. 依达拉奉对大鼠烧伤休克性急性肺损伤的保护作用 [J]. 江苏医药, 2009; 35（5）: 547548.
23. 邢海波, 李刚, 徐亚平, 等. 依达拉奉对脓毒症大鼠肺损伤的保护作用 [J]. 中国呼吸与危重监护杂志, 2009; 8（2）: 176180.
24. 尤再春, 史忠, 高全杰, 等. 依达拉奉对百草枯中毒致急性肺损伤预防及治疗作用研究 [J]. 重庆医学, 2008; 37（22）: 25172519.
25. 张卓一, 徐秋萍. 依达拉奉在急性肺损伤大鼠中的抗氧自由基作用 [J]. 浙江医学, 2007; 29（6）: 542544.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effects of Edaravone on Lung Injury of Severe Acute Pancreatitis in Rats

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