Clinical Analysis of Therapeutic Effects of Ultrasound-Guided Percutaneous Microwave Ablation for Hepatic Metastases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIN Zhongtian ¹ , PENG Jirun ¹ , ZHU Weihua ¹ , ZHANG Dafang ¹ , GAN Liyun ² , LI Shu ¹ , WANG Fushun ¹ , ZHU Jiye ¹ , LENG Xisheng ¹

1.Center of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing 100044, China;;
2.Department of Ultrasound, Peking University People’s Hospital, Beijing 100044, China;

Corresponding author：

Keywords：

Liver neoplasm; Ultrasound; Microwave; Ablation; Neoplasm metastasis

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the therapeutic effects of percutaneous microwave ablation (MWA) for metastatic liver cancer.
Methods Ultrasound-guided percutaneous MWA technique was used to treat 27 cases of hepatic metastases with 69 nodules 〔0.9-13.2 (3.0±2.0) cm in diameter〕. Local therapeutic effect, local and distant recurrence rate and survival rate were evaluated respectively.
Results The complete ablation (CA) rate which was used to evaluate the local therapeutic effects was 92.8% (64/69), with 100% (34/34), 92.3%(24/26) and 66.7% (6/9) in a diameter of nodules lt;3.0 cm, 3.0-5.0 cm and ≥5.0 cm respectively. The CA rate was lower in the group of a diameter of nodules ≥5.0 cm as compared with other two groups (P lt;0.05). The local recurrence rate was 9.4% (6/64), with 2.9% (1/34), 16.7% (4/24) and 16.7% (1/6) in a diameter of nodules lt;3.0 cm, 3.0-5.0 cm and ≥5.0 cm respectively. The intrahepatic distant recurrence rate was 44.4% (12/27). The follow-up time after MWA was 3－34 (17.0±8.7) months. During the follow-up period, 6 months, 1 and 2-year cumulative survival rate was 88.9%, 63.0% and 34.4% respectively, with a mean survival time of 17.8 months, and with a median survival time of 19.0 months.
Conclusion Percutaneous MWA treatment offers satisfactory local tumoricidal efficacy to metastatic liver cancer and the patients with recurrence and new metastases can be therapy repeatedly to improve long-term survival.

Citation： JIN Zhongtian ,PENG Jirun,ZHU Weihua,ZHANG Dafang,GAN Liyun,LI Shu,WANG Fushun,ZHU Jiye,LENG Xisheng. Clinical Analysis of Therapeutic Effects of Ultrasound-Guided Percutaneous Microwave Ablation for Hepatic Metastases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(3): 229-232. doi: Copy

1.	Taylor I. Liver metastases from colorectal cancer: lessons from past and present clinical studies [J]. Br J Surg, 1996; 83(4): 456460.
2.	Dromain C, de Baere T, Elias D, et al. Hepatic tumors treated with percutaneous radiofrequency ablation: CT and MR imaging followup [J]. Radiology, 2002; 223(1): 255262.
3.	Cascinu S, Catalano V, Baldelli AM, et al. Locoregional treatments of unresectable liver metastases from colorectal cancer [J]. Cancer Treat Rev, 1998; 24(1): 314.
4.	Seki T, Wakabayashi M, Nakagawa T, et al. Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular carcinoma [J]. Cancer, 1994; 74(3): 817825.
5.	吕明德. 影像引导肝癌消融治疗的效果和临床地位 [J]. 中国普外基础与临床杂志, 2006; 13(2): 138139.
6.	谢晓燕，殷晓煜，吕明德，等. 超声引导经皮射频消融治疗肝癌局部疗效影响因素的探讨 [J]. 中华肝胆外科杂志, 2004; 10(10): 676678.
7.	Seki T, Tamai T, Nakagawa T, et al. Combination therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation therapy for hepatocellular carcinoma [J]. Cancer, 2000; 89(6): 12451251.
8.	梁萍，董宝玮，于晓玲，等. 超声引导经皮微波消融治疗肝转移癌疗效评价 [J]. 中华医学杂志， 2006; 86(12): 806810.
9.	黄韬，李波，林浩铭，等. 转移性肝癌的外科治疗(附208例报告) [J]. 中国普外基础与临床杂志, 2005; 12(3): 294295.

1. Taylor I. Liver metastases from colorectal cancer: lessons from past and present clinical studies [J]. Br J Surg, 1996; 83(4): 456460.
2. Dromain C, de Baere T, Elias D, et al. Hepatic tumors treated with percutaneous radiofrequency ablation: CT and MR imaging followup [J]. Radiology, 2002; 223(1): 255262.
3. Cascinu S, Catalano V, Baldelli AM, et al. Locoregional treatments of unresectable liver metastases from colorectal cancer [J]. Cancer Treat Rev, 1998; 24(1): 314.
4. Seki T, Wakabayashi M, Nakagawa T, et al. Ultrasonically guided percutaneous microwave coagulation therapy for small hepatocellular carcinoma [J]. Cancer, 1994; 74(3): 817825.
5. 吕明德. 影像引导肝癌消融治疗的效果和临床地位 [J]. 中国普外基础与临床杂志, 2006; 13(2): 138139.
6. 谢晓燕，殷晓煜，吕明德，等. 超声引导经皮射频消融治疗肝癌局部疗效影响因素的探讨 [J]. 中华肝胆外科杂志, 2004; 10(10): 676678.
7. Seki T, Tamai T, Nakagawa T, et al. Combination therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation therapy for hepatocellular carcinoma [J]. Cancer, 2000; 89(6): 12451251.
8. 梁萍，董宝玮，于晓玲，等. 超声引导经皮微波消融治疗肝转移癌疗效评价 [J]. 中华医学杂志， 2006; 86(12): 806810.
9. 黄韬，李波，林浩铭，等. 转移性肝癌的外科治疗(附208例报告) [J]. 中国普外基础与临床杂志, 2005; 12(3): 294295.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Analysis of Therapeutic Effects of Ultrasound-Guided Percutaneous Microwave Ablation for Hepatic Metastases

Abstract Full text Figures/Tables Video References Cited by

Format

Content