Relationship Between Postoperative Blood Glucose and Complications and Different Nutrition for Patients with Gastric Cancer Combinated Diabetes_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

1.Department of General Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022;;
2.Department of Gastrointestinal Surgery, Hubei Provincial Crops Hospital of Chinese People’s Armed Police Force, Wuhan 430061;;
3.Department of Tumor Surgery,4.Department of Endocrine,, Affiliated Hospital of Medical College of Chinese People’s Armed Police Force, Tianjin 300162;

Corresponding author：

Keywords：

Gastric cancer; Diabetes; Enteral nutrition; Total parenteral nutrition; FresubinTM diabetes

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

　　　　Methods 　Sixty-six postoperative patients with gastric cancer combined diabetes were divided into 3 groups according to the balanced principle. In the frist group (FD group), FD was the nutrition preparation for 21 patients. In the second group (fresubin group), fresubin and the ordinary insulin injection were the nutrition preparation for 21 patients. In the third group (TPN group), the nutrition preparation came from TPN and the ordinary insulin injection for 24 patients. FD, fresubin or TPN were given at 24 h after operation, the levels of blood glucose for empty stomach, after meal (enteral nutrition or TPN) and the common complications
compared among 3 groups of postoperative patients.
　　Results 　① In FD group, the levels of blood glucose of postoperative empty stomach and after enteral nutrition were stable with little fluctuation and no insulin was needed with 1 case of hyperglycemia (4.8%). In fresubin group and TPN group, the levels of blood glucose of postoperative empty stomach and after enteral nutrition or TPN were unstable with big fluctuation, with 6 cases (28.6%) and 8 cases (33.3%) of hyperglycemia, 5 cases (23.8%) and 6 cases (25.0%) of hypoglycemia in fresubin group and TPN group, respectively. Compared with fresubin group and TPN group, the rate of pathoglycemia was lower in FD group, the difference had statistical significance separately (P lt;0.05); There was no significant difference between fresubin group and TPN group (P gt;0.05). ② The rates of infection of incisional wound in FD group (4.8%) and fresubin group (23.8%) were lower than that of TPN group (33.3%), there was significant difference among 3 groups (P lt;0.05); The time of passage of gas by anus in FD group and fresubin group were shorter than that in TPN group (P lt;0.05); There was no significant difference between FD group and fresubin group (P gt;0.05). There were no significant differences of the rates of abdominal distension or diarrhea among 3 groups (P gt;0.05).
　　Conclusion 　Regarding postoperative patients with gastric cancer combined diabetes, in the early time field test group of the nutrition preparation, FD is better than fresubin or TPN, which does not increase the risk of the blood glucose change and have few complications.

Citation： REN Guibing,WANG Jiliang,WANG Guobin,TAO Kaixiong,XIA Zefeng,ZHAO Duanyi,MAO Zhongpeng,WU Fengyun,ZHAO Cailing. Relationship Between Postoperative Blood Glucose and Complications and Different Nutrition for Patients with Gastric Cancer Combinated Diabetes. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(4): 352-356. doi: Copy

1.	卢晓明, 牛彦锋, 王国斌, 等. 肠内营养对胃癌术后近期的免疫和营养状况的影响 [J]. 世界华人消化杂志, 2004; 12(9): 2225-2227.
2.	罗世成, 郭建辉, 朱军, 等. 胃肠道肿瘤患者术后早期肠内营养与肠外营养支持的随机对照研究 [J]. 中国普外基础与临床杂志, 2007; 14(3): 324-328.
3.	徐向进, 潘长玉, 田慧, 等. WHO及美国糖尿病学会糖尿病诊断标准在老年人群中应用的分析和评估 [J]. 中华内分泌代谢杂志, 2002; 18(5): 357-358.
4.	舒晓亮, 李萍, 陈欢欢, 等. 含缓释淀粉的肠内营养剂对高血糖危重患者的影响 [J]. 同济大学学报(医学版), 2006; 27(1): 65-67.
5.	彭宏伟, 史平淮. 胃癌合并糖尿病患者术后早期肠内营养效果分析 [J]. 苏州大学学报(医学版), 2009; 29(2): 364-365.
6.	李江, 刘斌, 侯宇, 等. 腹部外科术后早期肠内营养的临床研究与应用 [J]. 中国普外基础与临床杂志, 2006; 13(3): 355-357.
7.	徐红, 庄文, 周勇. 消化道肿瘤病人术后应用肠内营养的临床研究 [J]. 华西医学, 2004; 19(1): 60-61.
8.	赵素斌, 谷俊霞, 张宪斌, 等. 胃肠道术后瑞素早期肠内营养的应用 [J]. 肠外与肠内营养, 2003; 10(3): 134-136.
9.	胡建昆. 外科手术后早期肠内营养 [J]. 中国普外基础与临床杂志, 2003; 10(4): 407-409.
10.	黎介寿. 肠内营养-外科临床营养支持的首选途径 [J]. 肠外与肠内营养, 2003; 10(3): 129-130.
11.	秦环龙, 杨俊. 外科营养的现状与展望 [J]. 中国普外基础与临床杂志, 2008; 111(5): 791-793.
12.	尹华, 周玮, 卢爱国. 43例胃癌合并糖尿病围手术期治疗分析 [J]. 中国现代医学杂志, 2005; 15(4): 558-559, 562.
13.	李红浪, 熊炳贤, 王梦龙. 老年胃癌合并糖尿病95例的外科治疗 [J]. 实用癌症杂志, 2005; 20(2): 164-165, 168.
14.	王定明, 梁一举, 杨军. 28例糖尿病患者胃癌围手术期处理体会 [J]. 现代医药卫生, 2006; 22(3): 341-342.
15.	张伟, 赵高平, 杨春, 等. 胃肠道肿瘤合并糖尿病患者术后早期肠内营养支持及血糖控制 [J]. 中国普外基础与临床杂志, 2008; 15(6): 444-447.
16.	Pomposelli JJ, Baxter JK 3rd, Babineau TJ, et al. Early postoperative glucose control predicts nosocomial infection rate in diabetic patients [J]. JPEN J Parenter Enteral Nutr, 1998; 22(2): 77-81.
17.	王姮, 蒋朱明, 袁申元, 等. 含缓释淀粉的整蛋白型肠内营养剂对脏器功能、血胰岛素/血糖曲线下面积及血糖的影响(120例随机、对照、多中心临床研究) [J]. 中国临床营养杂志, 2002; 10(2): 75-78.
18.	Elia M, Carrillo A, Labe H, et al. Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes. A systematic review and meta-analysis [J]. Diabetes Care, 2005; 28(9): 2267-2279.
19.	周莹霞, 陈钦达, 王琴琴, 等. 富含缓释淀粉的肠内营养乳剂对2型糖尿病血糖及胰岛素的影响 [J]. 上海医学, 2004; 27(2): 116-118.
20.	Corpe CP, Burant CF, Hoekstra JH. Intestinal fructose absorption: clinical and molecular aspects [J]. J Pediatr Gastroenterol Nutr, 1999; 28(4): 364-374.

1. 卢晓明, 牛彦锋, 王国斌, 等. 肠内营养对胃癌术后近期的免疫和营养状况的影响 [J]. 世界华人消化杂志, 2004; 12(9): 2225-2227.
2. 　罗世成, 郭建辉, 朱军, 等. 胃肠道肿瘤患者术后早期肠内营养与肠外营养支持的随机对照研究 [J]. 中国普外基础与临床杂志, 2007; 14(3): 324-328.
3. 　徐向进, 潘长玉, 田慧, 等. WHO及美国糖尿病学会糖尿病诊断标准在老年人群中应用的分析和评估 [J]. 中华内分泌代谢杂志, 2002; 18(5): 357-358.
4. 　舒晓亮, 李萍, 陈欢欢, 等. 含缓释淀粉的肠内营养剂对高血糖危重患者的影响 [J]. 同济大学学报(医学版), 2006; 27(1): 65-67.
5. 　彭宏伟, 史平淮. 胃癌合并糖尿病患者术后早期肠内营养效果分析 [J]. 苏州大学学报(医学版), 2009; 29(2): 364-365.
6. 　李江, 刘斌, 侯宇, 等. 腹部外科术后早期肠内营养的临床研究与应用 [J]. 中国普外基础与临床杂志, 2006; 13(3): 355-357.
7. 　徐红, 庄文, 周勇. 消化道肿瘤病人术后应用肠内营养的临床研究 [J]. 华西医学, 2004; 19(1): 60-61.
8. 　赵素斌, 谷俊霞, 张宪斌, 等. 胃肠道术后瑞素早期肠内营养的应用 [J]. 肠外与肠内营养, 2003; 10(3): 134-136.
9. 　胡建昆. 外科手术后早期肠内营养 [J]. 中国普外基础与临床杂志, 2003; 10(4): 407-409.
10. 　黎介寿. 肠内营养-外科临床营养支持的首选途径 [J]. 肠外与肠内营养, 2003; 10(3): 129-130.
11. 　秦环龙, 杨俊. 外科营养的现状与展望 [J]. 中国普外基础与临床杂志, 2008; 111(5): 791-793.
12. 　尹华, 周玮, 卢爱国. 43例胃癌合并糖尿病围手术期治疗分析 [J]. 中国现代医学杂志, 2005; 15(4): 558-559, 562.
13. 　李红浪, 熊炳贤, 王梦龙. 老年胃癌合并糖尿病95例的外科治疗 [J]. 实用癌症杂志, 2005; 20(2): 164-165, 168.
14. 　王定明, 梁一举, 杨军. 28例糖尿病患者胃癌围手术期处理体会 [J]. 现代医药卫生, 2006; 22(3): 341-342.
15. 　张伟, 赵高平, 杨春, 等. 胃肠道肿瘤合并糖尿病患者术后早期肠内营养支持及血糖控制 [J]. 中国普外基础与临床杂志, 2008; 15(6): 444-447.
16. 　Pomposelli JJ, Baxter JK 3rd, Babineau TJ, et al. Early postoperative glucose control predicts nosocomial infection rate in diabetic patients [J]. JPEN J Parenter Enteral Nutr, 1998; 22(2): 77-81.
17. 　王姮, 蒋朱明, 袁申元, 等. 含缓释淀粉的整蛋白型肠内营养剂对脏器功能、血胰岛素/血糖曲线下面积及血糖的影响(120例随机、对照、多中心临床研究) [J]. 中国临床营养杂志, 2002; 10(2): 75-78.
18. 　Elia M, Carrillo A, Labe H, et al. Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes. A systematic review and meta-analysis [J]. Diabetes Care, 2005; 28(9): 2267-2279.
19. 　周莹霞, 陈钦达, 王琴琴, 等. 富含缓释淀粉的肠内营养乳剂对2型糖尿病血糖及胰岛素的影响 [J]. 上海医学, 2004; 27(2): 116-118.
20. 　Corpe CP, Burant CF, Hoekstra JH. Intestinal fructose absorption: clinical and molecular aspects [J]. J Pediatr Gastroenterol Nutr, 1999; 28(4): 364-374.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between Postoperative Blood Glucose and Complications and Different Nutrition for Patients with Gastric Cancer Combinated Diabetes

Abstract Full text Figures/Tables Video References Cited by

Format

Content