Expressions and Significance of EGFR， C-erbB-2， VEGF and COX-2 in Human Gastric Cancer Tissues_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WEI Xueming ¹ , GU Guoli ¹ , REN Li ² , XIONG Mei ² , WANG Shilin ¹ , LI Dechang ²

1.Department of General Surgery， The General Hospital of Chinese PLA Air Force， Beijing 100142， China;;
2.Department of Pathology， The General Hospital of Chinese PLA Air Force， Beijing 100142， China;

Corresponding author：

Keywords：

Gastric cancer; Epidermal growth factor receptor; Vascular endothelial growth factor; Cyclooxygenase-2; Immunohistochemistry

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Objective To detect the expressions of epidermal growth factor receptor (EGFR), epidermal growth factor receptor-2 (C-erbB-2), vascular endothelial growth factor (VEGF) and cyclooxgenase-2 (COX-2) in gastric cancer tissues, and to analyze the relationship among them and the clinicopathologic factors of gastric cancer. Methods The SP immunohistochemical stain was used to detect EGFR, C-erbB-2, VEGF and COX-2 protein expressions in sample of 68 gastric cancer tissues. And their corresponding clinical data were analyzed retrospectively. Results The expression rates of EGFR, C-erbB-2, VEGF and COX-2 protein in gastric cancer tissue were 38.2% (26/68), 42.6% (29/68), 52.9% (36/68) and 60.3% (41/68) corresponding. An obvious increasing tendency as the differentiation of the cancer degraded, invasion depth deepened, lymphatic metastasis occurred and TNM stage upgraded was showed by the positive expression rates of them （P＜0.05，P＜0.01）; but there was no correlation with the patient’s sex, age, tumour site and size （P gt;0.05）. There was a stable positive correlation among EGFR, C-erbB-2, VEGF and COX-2 expressions in gastric cancer tissue, respectively （P＜0.05）. Conclusion EGFR, C-erbB-2, VEGF and COX-2 expressions participate in the development, invasion and metastasis process of gastric cancer. Joint detection of them can be looked as an important symbol for judging the prognosis of gastric cancer and screening the high-risk metastasis patients, and guiding the molecular targeting therapy of gastric cancer.

Citation： WEI Xueming,GU Guoli,REN Li,XIONG Mei,WANG Shilin,LI Dechang. Expressions and Significance of EGFR， C-erbB-2， VEGF and COX-2 in Human Gastric Cancer Tissues. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(11): 900-905. doi: Copy

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24.	邓渝林, 陶霞, 周静, 等. 第二代COX-2抑制剂的研究进展 [Ｊ]. 解放军药学学报, 2005; 21(3): 209-213.
25.	王广义, 王旭. 人胃癌VEGF和NOS的表达与肿瘤血管生成的关系 [Ｊ]. 中国普外基础与临床杂志, 2004; 11(1): 55-57.
26.	李敏, 陈健, 蒋敏, 等. 胃癌组织中c-erbB-2和组织蛋白酶D的表达及其与胃癌生物学行为间的关系 [Ｊ]. 中国普外基础与临床杂志, 2002; 9(2): 108-111.

1. 陈志新, 张波. 胃癌综合治疗现状及展望 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(1): 71-73.
2. 姜波健, 吴巨钢, 俞继卫, 等. 胃癌淋巴管生成、淋巴管浸润及淋巴结微转移的临床意义 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(12): 903-909.
3. 夏宝妹, 周怀君. 血管内皮生长因子家族与抗肿瘤血管生成 [Ｊ]. 国际妇产科学杂志, 2009; 36(2): 105-108.
4. 杜京涛, 许新华. 血管内皮生长因子在肿瘤中的研究进展 [Ｊ]. 肿瘤防治研究, 2009; 36(2): 162-165.
5. 肖炜明, 施瑞华, 丁岩冰, 等. 胃癌组织中EGFR和COX-2表达的意义及其相关性 [Ｊ]. 世界华人消化杂志, 2007; 15(2): 123-128.
6. Rocha-Lima CM, Soares HP, Raez LE, et al. EGFR targeting of solid tumors [Ｊ]. Cancer Control, 2007; 14(3): 295-304.
7. 刘磊, 白玉贤. EGFR靶向药物治疗胃肠道肿瘤的新进展 [Ｊ]. 实用肿瘤学杂志, 2008; 22(4): 382-384.
8. Alekshun T, Garrett C. Targeted therapies in the treatment of colorectal cancers [Ｊ]. Cancer Control, 2005; 12(2): 105-110.
9. 陈波, 孙继元, 金锋, 等. 关于胃癌TNM分期系统中最少淋巴结检出数目的研究 [Ｊ]. 中华外科杂志, 2005; 43 (11): 702-705.
10. Ciardiello F, Tortora G. EGFR antagonists in cancer treatment [Ｊ]. N Engl J Med, 2008; 358(11): 1160-1174.
11. 付建华, 赵曼, 胡国强, 等. EGFR和E-cadherin与肿瘤的发生发展及其调控机制的研究进展 [Ｊ]. 实用癌症杂志, 2008; 23(1): 107-109.
12. Molinari F, Martin V, Saletti P, et al. Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant [Ｊ]. Br J Cancer, 2009; 100(7): 1087-1094.
13. 郁宝铭. 结直肠癌分子靶向治疗药物研究现状 [Ｊ]. 世界华人消化杂志, 2008; 16(33): 3705-3712.
14. 吴军, 叶正宝, 马韬, 等. 西妥昔单抗联合FOLFOX4治疗晚期胃癌一例报道 [Ｊ]. 外科理论与实践, 2008; 13(3): 282-283.
15. Sirica AE. Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma [Ｊ]. World J Gastroenterol, 2008; 14(46): 7033-7058.
16. Ochs AM, Wong L, Kakani V, et al. Expression of vascular endothelial growth factor and HER2/neu in stage II colon cancer and correlation with survival [Ｊ]. Clin Colorectal Cancer, 2004; 4(4): 262-267.
17. 杨春明. 乳腺癌治疗的现代概念 [Ｊ]. 中国普外基础与临床杂志, 2008; 15(7): 467-470.
18. 欧希龙, 关云艳, 颜芳, 等. 血管内皮生长因子165基因对人胃癌细胞凋亡的影响及机制 [Ｊ]. 世界华人消化杂志, 2008; 16(3): 307-310.
19. Su JL, Yang PC, Shih JY, et al. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells [Ｊ]. Cancer Cell, 2006; 9(3): 209-223.
20. Goldberg RM, Carrato A. Accomplishments in 2007 in the treatment of advanced colorectal cancer [Ｊ]. Gastrointest Cancer Res, 2008; 2(3 Suppl): S19-S24.
21. Morabito A, De Maio E, Di Maio M, et al. Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions [Ｊ]. Oncologist, 2006; 11(7): 753-764.
22. Cutler NS, Graves-Deal R, LaFleur BJ, et al. Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells [Ｊ]. Cancer Res, 2003; 63(8): 1748-1751.
23. 汪斐, 莫烨, 周世权, 等. COX-2和HER-2在结直肠癌中的表达及其意义 [Ｊ]. 中国普通外科杂志, 2007; 16(7): 693-695.
24. 邓渝林, 陶霞, 周静, 等. 第二代COX-2抑制剂的研究进展 [Ｊ]. 解放军药学学报, 2005; 21(3): 209-213.
25. 王广义, 王旭. 人胃癌VEGF和NOS的表达与肿瘤血管生成的关系 [Ｊ]. 中国普外基础与临床杂志, 2004; 11(1): 55-57.
26. 李敏, 陈健, 蒋敏, 等. 胃癌组织中c-erbB-2和组织蛋白酶D的表达及其与胃癌生物学行为间的关系 [Ｊ]. 中国普外基础与临床杂志, 2002; 9(2): 108-111.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expressions and Significance of EGFR， C-erbB-2， VEGF and COX-2 in Human Gastric Cancer Tissues

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