Value of Preoperative Serum Amyloid A Protein Concentration in Choice of Surgical Treatment in Low Locally Advanced Rectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Xiaodong ¹ , DENG Lei ² , QIN Changlong ² , Lu Donghao ² , PENG Xiaying ² , NA Feifei ² , LI Zhengyan ³ , LI Li ¹

1.Department of Anal-Colorectal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;;
2.West China School of Medicine, Sichuan University, Chengdu 610041, China;;
3.Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Rectal neoplasm; Locally advanced rectal cancer; Surgical operation; Serum amyloid A protein; Preoperative evaluation

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the relationship of serum amyloid A protein (SAA) and surgical choice in low locally advanced rectal cancer (LLARC).
Methods Fifty-two patients with LLARC at West China Hospital of Sichuan University were retrospectively analyzed. According to operative methods the patients were divided into 2 groups: curative surgery group (n=35) and palliative surgery group (n=17). Then, venous blood specimens were taken to measure preoperative serum SAA level.
Results The analysis showed the option of surgical procedures was associated with preoperative SAA concentration (P=0.004) in LLARC, but irrelative with pathological characteristics and preoperative imaginologic staging (P gt;0.05). High concentration of serum SAA (≥10.5 mg/L) significantly increased the odds of palliative surgery 〔OR=7.47, 95% CI (1.62-34.40), P＝0.010〕.
Conclusion High level of SAA is a useful marker to predict the possibility of palliative surgery in LLARC, which is helpful to screen the patients for the surgical decision and adjuvant therapy.

Citation： WANG Xiaodong ,DENG Lei,QIN Changlong,Lu Donghao,PENG Xiaying,NA Feifei,LI Zhengyan,LI Li. Value of Preoperative Serum Amyloid A Protein Concentration in Choice of Surgical Treatment in Low Locally Advanced Rectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2009, 16(8): 667-670. doi: Copy

1.	Lafrenière R. What’s new in general surgery: surgical oncology [Ｊ]. J Am Coll Surg, 2004; 198(6): 966-988.
2.	吴俊华, 汪晓东, 高强, 等. 64排多层螺旋CT和血清淀粉样蛋白A联合评估下段直肠癌对手术方案选择的影响 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(2): 156-161.
3.	汪晓东, 宋欢, 吕东昊, 等. 术前联合评估直肠上段癌与手术方案选择的随机对照试验 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(4): 322-326.
4.	汪晓东, 尹源, 陆玫竹, 等. 经直肠超声联合血清淀粉样蛋白A术前评估中低位直肠癌与手术决策的随机对照试验 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(5): 407-412.
5.	汪晓东, 吕东昊, 宋欢, 等. 多模式术前评估系统对中低位直肠癌手术方案选择的价值：一项随机对照试验 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(6): 487-492.
6.	Theoni RF. Colorectal cancer: cross-sectional imaging for st-aging of primary tumor and detection of local recurrence [Ｊ]. AJR Am J Roentgenol, 1991; 156(5): 909-915.
7.	Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual [M]. 6th ed. New York (NY). Springer-Verlag, 2002: 113-124.
8.	Nelson H, Petrelli N, Carlin A, et al. Guidelines 2000 for colon and rectal cancer surgery [Ｊ]. J Natl Cancer Inst, 2001; 93(8): 583-596.
9.	汪晓东, 宋欢, 卢聪, 等. 骨盆测量在直肠癌手术中的应用进展 [Ｊ]. 医学与哲学, 2009; 30(4): 45-46.
10.	汪晓东, 何帆, 邓窈窕, 等. 直肠癌术前经直肠超声评估保肛或非保肛手术方案的临床前瞻性研究 [Ｊ]. 临床外科杂志, 2008; 16(11): 755-757.
11.	Abbas MA. Sphincter preservation for distal rectal cancer: how low is too low? [Ｊ]. Am J Clin Oncol, 2008; 31(2): 195-198.
12.	汪晓东, 吕东昊, 宋欢, 等. 64排螺旋CT术前评估对直肠癌手术方案选择的价值 [Ｊ]. 中华普通外科杂志, 2009; 24(3): 210-214.
13.	汪晓东, 吕东昊, 崔贝贝, 等. 术前经直肠超声评估直肠癌手术方案的随机对照试验 [Ｊ]. 中国循证医学杂志, 2008; 8(12): 1043-1046.
14.	Leroy J, Jamali F, Forbes L, et al. Laparoscopic total mesorectal excision (TME) for rectal cancer surgery: long-term outcomes [Ｊ]. Surg Endosc, 2004; 18(2): 281-289.
15.	Sugarbaker PH, Corlew S. Influence of surgical techniques on survival in patients with colorectal cancer [Ｊ]. Dis Colon Rectum, 1982; 25(6): 545-557.
16.	Lindsetmo RO, Joh YG, Delaney CP. Surgical treatment for rectal cancer: an international perspective on what the medical gastroenterologist needs to know [Ｊ]. World J Gastroenterol, 2008; 14(21): 3281-3289.
17.	Strassburg J, Lewin A, Ludwig K, et al. Optimised surgery (so-called TME surgery) and high-resolution MRI in the planning of treatment of rectal carcinoma [Ｊ]. Langenbecks Arch Surg, 2007; 392(2): 179-188.
18.	Wibe A, Mller B, Norstein J, et al. A national strategic change in treatment policy for rectal cancer-implementation of total mesorectal excision as routine treatment in Norway. A national audit [Ｊ]. Dis Colon Rectum, 2002; 45(7): 857-866.
19.	汪晓东, 高强, 周小雁, 等. 多层螺旋CT联合纤维蛋白原或血清淀粉样蛋白A对直肠癌外科决策的随机对照研究 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(7): 575-580.
20.	Gutfeld O, Prus D, Ackerman Z, et al. Expression of serum amyloid A, in normal, dysplastic, and neoplastic human colonic mucosa: implication for a role in colonic tumorigenesis [Ｊ]. J Histochem Cytochem, 2006; 54(1): 63-73.
21.	汪晓东, 吕东昊, 高命, 等. 结直肠癌患者术前血清CRP与SAA检测的意义 [Ｊ]. 中国肿瘤, 2009; 18(5): 416-419.
22.	汪晓东, 邓磊, 吕东昊, 等. 结直肠癌患者术前SAA、CRP、CEA和CA19-9水平的临床诊断价值 [Ｊ]. 四川医学, 2009; 30(3): 340-342.
23.	刘展, 汪晓东, 李立. 在结直肠癌领域引入多学科协作管理模式的现状 [Ｊ]. 中国普外基础与临床杂志, 2007; 14(1): 114-116.
24.	Daniels IR, Fisher SE, Heald RJ, et al. Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence [Ｊ]. Colorectal Dis, 2007; 9(4): 290-301.

1. Lafrenière R. What’s new in general surgery: surgical oncology [Ｊ]. J Am Coll Surg, 2004; 198(6): 966-988.
2. 吴俊华, 汪晓东, 高强, 等. 64排多层螺旋CT和血清淀粉样蛋白A联合评估下段直肠癌对手术方案选择的影响 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(2): 156-161.
3. 汪晓东, 宋欢, 吕东昊, 等. 术前联合评估直肠上段癌与手术方案选择的随机对照试验 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(4): 322-326.
4. 汪晓东, 尹源, 陆玫竹, 等. 经直肠超声联合血清淀粉样蛋白A术前评估中低位直肠癌与手术决策的随机对照试验 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(5): 407-412.
5. 汪晓东, 吕东昊, 宋欢, 等. 多模式术前评估系统对中低位直肠癌手术方案选择的价值：一项随机对照试验 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(6): 487-492.
6. Theoni RF. Colorectal cancer: cross-sectional imaging for st-aging of primary tumor and detection of local recurrence [Ｊ]. AJR Am J Roentgenol, 1991; 156(5): 909-915.
7. Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual [M]. 6th ed. New York (NY). Springer-Verlag, 2002: 113-124.
8. Nelson H, Petrelli N, Carlin A, et al. Guidelines 2000 for colon and rectal cancer surgery [Ｊ]. J Natl Cancer Inst, 2001; 93(8): 583-596.
9. 汪晓东, 宋欢, 卢聪, 等. 骨盆测量在直肠癌手术中的应用进展 [Ｊ]. 医学与哲学, 2009; 30(4): 45-46.
10. 汪晓东, 何帆, 邓窈窕, 等. 直肠癌术前经直肠超声评估保肛或非保肛手术方案的临床前瞻性研究 [Ｊ]. 临床外科杂志, 2008; 16(11): 755-757.
11. Abbas MA. Sphincter preservation for distal rectal cancer: how low is too low? [Ｊ]. Am J Clin Oncol, 2008; 31(2): 195-198.
12. 汪晓东, 吕东昊, 宋欢, 等. 64排螺旋CT术前评估对直肠癌手术方案选择的价值 [Ｊ]. 中华普通外科杂志, 2009; 24(3): 210-214.
13. 汪晓东, 吕东昊, 崔贝贝, 等. 术前经直肠超声评估直肠癌手术方案的随机对照试验 [Ｊ]. 中国循证医学杂志, 2008; 8(12): 1043-1046.
14. Leroy J, Jamali F, Forbes L, et al. Laparoscopic total mesorectal excision (TME) for rectal cancer surgery: long-term outcomes [Ｊ]. Surg Endosc, 2004; 18(2): 281-289.
15. Sugarbaker PH, Corlew S. Influence of surgical techniques on survival in patients with colorectal cancer [Ｊ]. Dis Colon Rectum, 1982; 25(6): 545-557.
16. Lindsetmo RO, Joh YG, Delaney CP. Surgical treatment for rectal cancer: an international perspective on what the medical gastroenterologist needs to know [Ｊ]. World J Gastroenterol, 2008; 14(21): 3281-3289.
17. Strassburg J, Lewin A, Ludwig K, et al. Optimised surgery (so-called TME surgery) and high-resolution MRI in the planning of treatment of rectal carcinoma [Ｊ]. Langenbecks Arch Surg, 2007; 392(2): 179-188.
18. Wibe A, Mller B, Norstein J, et al. A national strategic change in treatment policy for rectal cancer-implementation of total mesorectal excision as routine treatment in Norway. A national audit [Ｊ]. Dis Colon Rectum, 2002; 45(7): 857-866.
19. 汪晓东, 高强, 周小雁, 等. 多层螺旋CT联合纤维蛋白原或血清淀粉样蛋白A对直肠癌外科决策的随机对照研究 [Ｊ]. 中国普外基础与临床杂志, 2009; 16(7): 575-580.
20. Gutfeld O, Prus D, Ackerman Z, et al. Expression of serum amyloid A, in normal, dysplastic, and neoplastic human colonic mucosa: implication for a role in colonic tumorigenesis [Ｊ]. J Histochem Cytochem, 2006; 54(1): 63-73.
21. 汪晓东, 吕东昊, 高命, 等. 结直肠癌患者术前血清CRP与SAA检测的意义 [Ｊ]. 中国肿瘤, 2009; 18(5): 416-419.
22. 汪晓东, 邓磊, 吕东昊, 等. 结直肠癌患者术前SAA、CRP、CEA和CA19-9水平的临床诊断价值 [Ｊ]. 四川医学, 2009; 30(3): 340-342.
23. 刘展, 汪晓东, 李立. 在结直肠癌领域引入多学科协作管理模式的现状 [Ｊ]. 中国普外基础与临床杂志, 2007; 14(1): 114-116.
24. Daniels IR, Fisher SE, Heald RJ, et al. Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence [Ｊ]. Colorectal Dis, 2007; 9(4): 290-301.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Value of Preoperative Serum Amyloid A Protein Concentration in Choice of Surgical Treatment in Low Locally Advanced Rectal Cancer

Abstract Full text Figures/Tables Video References Cited by

Format

Content