c-met Expression in Tall Cell Variant Papillary Carcinoma of The Thyroid_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Chunxu ¹ , WANG Qiang ² , LI Yanfu ¹

1.Department of General Surgery, 153 Hospital of PLA, Zhengzhou 450007, China;;
2. Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China;

Corresponding author：

Keywords：

c-met protein; 　　Papillary thyroid carcinoma; 　　Tall cell variant; 　　Invasion

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the expression of c-met in tall cell variant of papillary thyroid carcinoma, and to compare it with other types of thyroid carcinoma and benign thyroid tissue. Methods The expressions of c-met in 60 cases of thyroid specimens were tested by immunohistochemical staining. Results The levels of expressed c-met in tall cell variant specimens were significantly higher than those in other types of papillary thyroid carcinoma and benign thyroid tissue. c-met expressions were significantly different in the following pairs of types: tall cell variant vs common papillary carcinoma of thyroid (P=0.000 1), tall cell variant vs follicular variant papillary thyroid carcinoma (P=0.000 1), and tall cell variant vs benign thyroid tissue (P=0.000 1). In addition, for all types of papillary carcinomas evaluated, c-met expression was significantly higher in specimens with extracapsular spread (P=0.010 0) and skeletal muscle invasion (P=0.020 0). Conclusion The high expression of c-met is a significant marker for tall cell variant papillary carcinoma of thyroid and its invasive behavior. This finding may explain the unusually aggressive behavior of this tumor and suggest a role for c-met in the early identification of patients with tall cell variant thyroid carcinoma.

Citation： ZHANG Chunxu,WANG Qiang,LI Yanfu. c-met Expression in Tall Cell Variant Papillary Carcinoma of The Thyroid. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(5): 318-322. doi: Copy

1.	魏韬哲主编. 现代甲状腺外科学 [M]. 河南：河南医科大学出版社， 1997∶22.
2.	Di Renzo MF, Olivero M, Ferro S, et al. Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas [Ｊ]. Oncogene, 1992; 7(12)∶2549.
3.	Ruco LP, Stoppacciaro A, Ballarini F, et al. Met protein and hepatocyte growth factor (HGF) in papillary carcinoma of the thyroid: evidence for a pathogenetic role in tumourigenesis [Ｊ]. J Pathol, 2001; 194(1)∶4.
4.	Rosen EM, Nigam SK, Goldberg ID. Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction [Ｊ]. J Cell Biol, 1994; 127(6 Pt 2)∶1783.
5.	唐波，姜军. RET原癌基因与分化性甲状腺癌关系的研究进展 [Ｊ]. 中国普外基础与临床杂志, 2004; 11（1）∶90.
6.	Johnson TL, Lloyd RV, Thompson NW, et al. Prognostic implications of the tall cell variant of papillary thyroid carcinoma [Ｊ]. Am J Surg Pathol, 1988; 12(1)∶22.
7.	Hawk WA, Hazard JB. The many appearances of papillary carcinoma of the thyroid [Ｊ]. Cleve Clin Q, 1976; 43(4)∶207.
8.	Bottaro DP, Rubin JS, Faletto DL, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product [Ｊ]. Science, 1991; 251(4995)∶802.
9.	Di Renzo MF, Narsimhan RP, Olivero M, et al. Expression of the Met/HGF receptor in normal and neoplastic human tissues [Ｊ]. Oncogene, 1991; 6(11)∶1997.
10.	Jeffers M, Rao MS, Rulong S, et al. Hepatocyte growth factor/scatter factor-Met signaling induces proliferation, migration, and morphogenesis of pancreatic oval cells [Ｊ]. Cell Growth Differ, 1996; 7(12)∶1805.
11.	杨卫军，黄志刚，李春来，等. c-met mRNA在乳腺癌术后腋窝引流液中表达的意义 [Ｊ]. 中国普外基础与临床杂志, 2007; 14（3）∶261.
12.	Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family [Ｊ]. Cell, 1994; 77(2)∶261.
13.	De Luca A, Arena N, Sena LM, et al. Met overexpression confers HGF-dependent invasive phenotype to human thyroid carcinoma cells in vitro [Ｊ]. J Cell Physiol, 1999; 180(2)∶365.
14.	Giordano S, Di Renzo MF, Narsimhan RP, et al. Biosynthesis of the protein encoded by the c-met proto-oncogene [Ｊ]. Oncogene, 1989; 4(11)∶1383.
15.	Giordano S, Ponzetto C, Di Renzo MF, et al. Tyrosine kinase receptor indistinguishable from the c-met protein [Ｊ]. Nature, 1989; 339(6220)∶155.
16.	Zanetti A, Stoppacciaro A, Marzullo A, et al. Expression of Met protein and urokinase-type plasminogen activator receptor (uPA-R) in papillary carcinoma of the thyroid [Ｊ]. J Pathol, 1998; 186(3)∶287.
17.	Ramirez R, Hsu D, Patel A, et al. Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma [Ｊ]. Clin Endocrinol (Oxf), 2000; 53(5)∶635.
18.	Scarpino S, Stoppacciaro A, Colarossi C, et al. Hepatocyte growth factor (HGF) stimulates tumour invasiveness in papillary carcinoma of the thyroid [Ｊ]. J Pathol, 1999; 189(4)∶570.
19.	Lorenzato A, Olivero M, Patanè S, et al. Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion [Ｊ]. Cancer Res, 2002; 62(23)∶7025.
20.	Ghoussoub RA, Dillon DA, D’Aquila, et al. Expression of c-met is a strong independent prognostic factor in breast carcinoma [Ｊ]. Cancer, 1998; 82(8)∶1513.
21.	Chen BK, Ohtsuki Y, Furihata M, et al. Overexpression of c-Met protein in human thyroid tumors correlated with lymph node metastasis and clinicopathologic stage [Ｊ]. Pathol Res Pract, 1999; 195(6)∶427.
22.	Ruco LP, Ranalli T, Marzullo A, et al. Expression of Met protein in thyroid tumours [Ｊ]. J Pathol, 1996; 180(3)∶266.
23.	Belfiore A, Gangemi P, Costantino A, et al. Negative/low expression of the Met/hepatocyte growth factor receptor identifies papillary thyroid carcinomas with high risk of distant metastases [Ｊ]. J Clin Endocrinol Metab, 1997; 82(7)∶2322.

1. 魏韬哲主编. 现代甲状腺外科学 [M]. 河南：河南医科大学出版社， 1997∶22.
2. Di Renzo MF, Olivero M, Ferro S, et al. Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas [Ｊ]. Oncogene, 1992; 7(12)∶2549.
3. Ruco LP, Stoppacciaro A, Ballarini F, et al. Met protein and hepatocyte growth factor (HGF) in papillary carcinoma of the thyroid: evidence for a pathogenetic role in tumourigenesis [Ｊ]. J Pathol, 2001; 194(1)∶4.
4. Rosen EM, Nigam SK, Goldberg ID. Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction [Ｊ]. J Cell Biol, 1994; 127(6 Pt 2)∶1783.
5. 唐波，姜军. RET原癌基因与分化性甲状腺癌关系的研究进展 [Ｊ]. 中国普外基础与临床杂志, 2004; 11（1）∶90.
6. Johnson TL, Lloyd RV, Thompson NW, et al. Prognostic implications of the tall cell variant of papillary thyroid carcinoma [Ｊ]. Am J Surg Pathol, 1988; 12(1)∶22.
7. Hawk WA, Hazard JB. The many appearances of papillary carcinoma of the thyroid [Ｊ]. Cleve Clin Q, 1976; 43(4)∶207.
8. Bottaro DP, Rubin JS, Faletto DL, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product [Ｊ]. Science, 1991; 251(4995)∶802.
9. Di Renzo MF, Narsimhan RP, Olivero M, et al. Expression of the Met/HGF receptor in normal and neoplastic human tissues [Ｊ]. Oncogene, 1991; 6(11)∶1997.
10. Jeffers M, Rao MS, Rulong S, et al. Hepatocyte growth factor/scatter factor-Met signaling induces proliferation, migration, and morphogenesis of pancreatic oval cells [Ｊ]. Cell Growth Differ, 1996; 7(12)∶1805.
11. 杨卫军，黄志刚，李春来，等. c-met mRNA在乳腺癌术后腋窝引流液中表达的意义 [Ｊ]. 中国普外基础与临床杂志, 2007; 14（3）∶261.
12. Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family [Ｊ]. Cell, 1994; 77(2)∶261.
13. De Luca A, Arena N, Sena LM, et al. Met overexpression confers HGF-dependent invasive phenotype to human thyroid carcinoma cells in vitro [Ｊ]. J Cell Physiol, 1999; 180(2)∶365.
14. Giordano S, Di Renzo MF, Narsimhan RP, et al. Biosynthesis of the protein encoded by the c-met proto-oncogene [Ｊ]. Oncogene, 1989; 4(11)∶1383.
15. Giordano S, Ponzetto C, Di Renzo MF, et al. Tyrosine kinase receptor indistinguishable from the c-met protein [Ｊ]. Nature, 1989; 339(6220)∶155.
16. Zanetti A, Stoppacciaro A, Marzullo A, et al. Expression of Met protein and urokinase-type plasminogen activator receptor (uPA-R) in papillary carcinoma of the thyroid [Ｊ]. J Pathol, 1998; 186(3)∶287.
17. Ramirez R, Hsu D, Patel A, et al. Over-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma [Ｊ]. Clin Endocrinol (Oxf), 2000; 53(5)∶635.
18. Scarpino S, Stoppacciaro A, Colarossi C, et al. Hepatocyte growth factor (HGF) stimulates tumour invasiveness in papillary carcinoma of the thyroid [Ｊ]. J Pathol, 1999; 189(4)∶570.
19. Lorenzato A, Olivero M, Patanè S, et al. Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion [Ｊ]. Cancer Res, 2002; 62(23)∶7025.
20. Ghoussoub RA, Dillon DA, D’Aquila, et al. Expression of c-met is a strong independent prognostic factor in breast carcinoma [Ｊ]. Cancer, 1998; 82(8)∶1513.
21. Chen BK, Ohtsuki Y, Furihata M, et al. Overexpression of c-Met protein in human thyroid tumors correlated with lymph node metastasis and clinicopathologic stage [Ｊ]. Pathol Res Pract, 1999; 195(6)∶427.
22. Ruco LP, Ranalli T, Marzullo A, et al. Expression of Met protein in thyroid tumours [Ｊ]. J Pathol, 1996; 180(3)∶266.
23. Belfiore A, Gangemi P, Costantino A, et al. Negative/low expression of the Met/hepatocyte growth factor receptor identifies papillary thyroid carcinomas with high risk of distant metastases [Ｊ]. J Clin Endocrinol Metab, 1997; 82(7)∶2322.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

c-met Expression in Tall Cell Variant Papillary Carcinoma of The Thyroid

Abstract Full text Figures/Tables Video References Cited by

Format

Content