• 1. Department of Vascular Surgery;;
  • 2. Department of Dermatology, The First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China;
Vascular reconstruction; 　　Restenosis; 　　Prevention and treatment
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Objective　To review various kinds of therapeutic methods for restenosis after reconstructive vascular operation. Methods　The literatures about prevention and treatment for restenosis after reconstructive vascular operation were reviewed. Results　Therapeutic methods for vascular restenosis include gene therapy, drug treatment, placing external stent around the vein graft and physical therapy. The methods of gene therapy include transferring genes that inhibit the proliferation of vascular smooth muscle cell (VSMC) and inactivating genes that promote the proliferation of VSMC through technology of antisensenucleic acids or RNA interference. Conclusion　Current treatment for restenosis after reconstructive varscular operation have both advantages and disadvantages, some of which are still being disputed. With the development of the technology of molecular biology, gene therapy would be the most effective therapy method for vascular restenosis.

Citation： WU Guo,DING Xiaojie,SHI De. Status Quo in Prevention and Treatment for Restenosis after Reconstructive Vascular Operation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(6): 418-421. doi: Copy