Effect of Cholecystokinine on Nervous System_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

FENG Ning , WU Xiaoting

Department of General Surgery, West China Hospital Sichuan University, Chengdu 610041, ChinaCorresponding Author： WU Xiao-ting, E-mail： WXT1@medmail.com.cn;

Corresponding author：

Keywords：

Cholecystokinine; Nervous system; Neurotransmitter

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Objective 　To review the biologic characteristics and biologic effect of cholecystokinine (CCK) on the central nervous system.
Methods 　The literatures of recent years on research advancement of cholecystokinine as neurotransmitters/peptides in signal transduction, neuron protection and pain management in the central nervous system are reviewed.
Results 　CCK possesses the ability to suppress the convulsant effects of convulsants. CCK8 is able to reduce the neural damage caused and delay the neural aging. CCK antagonists play an important role in human pain transduction.
Conclusion 　CCK has been proven to be one of the richest neurotransmitters/neuropeptides as well as an important signal factor in the brain, and its important biologic effect is being confirmed.

Citation： FENG Ning,WU Xiaoting. Effect of Cholecystokinine on Nervous System. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(8): 628-630. doi: Copy

1.	20　孙登群, 孟翔凌. 胆囊收缩素在糖尿病并发胆囊结石中的地位与作用 [J]. 中国普外基础与临床杂志, 2006; 13(4)∶ 406 21　Manni L, Lundeberg T, Tirassa P, et al. Cholecystokinin-8 enhances nerve growth factor synthesis and promotes recovery of capsaicin-induced sensory deficit [J]. Br J Pharmacol, 2000; 129(4)∶ 744.
2.	Ghijsen WE, Leenders AG, Wiegant VM. Regulation of cholecystokinin release from central nerve terminals [J]. Peptides, 2001; 22 (8)∶ 1213.
3.	Tanganelli S, Fuxe K, Antonelli T, et al. Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates [J]. Peptides, 2001; 22(8)∶ 1229.
4.	Hkfelt T, Holmberg K, Shi TJ, et al. CCK-ergic mechanisms in sensory systems [J]. Scand J Clin Lab Invest Suppl, 2001; 234∶ 69.
5.	Blevins JE, Stanley BG, Reidelberger RD. Brain regions where cholecystokinin suppresses feeding in rats [J]. Brain Res, 2000; 860 (1-2)∶ 1.
6.	Migrenne S, Marsollier N, Cruciani-Guglielmacci C, et al. Importance of the gut-brain axis in the control of glucose homeostasis [J]. Curr Opin Pharmacol, 2006; 6(6)∶ 592.
7.	Eser D, Schüle C, Baghai TC, et al. Neuroactive steroids in depression and anxiety disorders: clinical studies [J]. Neuroendocrinology, 2006; 84(4)∶ 244.
8.	Graf R, Klauser S, Fukuoka SI, et al. The bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provides protection against premature activation of pancreatic juice[J]. Pancreatology, 2003; 3(3)∶ 195.
9.	Van de Wiele C, Signore A, Dierckx RA. Peptide receptor imaging: advances in the diagnosis of pulmonary diseases [J]. Am J Respir Med, 2002; 1(3)∶ 177.
10.	Eguiagaray JG, Egea J, Bravo-Cordero JJ, et al. Neurotransmitters, calcium signalling and neuronal communication [J]. Neurocirugia (Astur), 2004; 15(2)∶ 109.
11.	Schiffmann S. Localization and role of cholecystokinin and its receptors in the functional organization of the basal ganglia [J]. Bull Mem Acad R Med Belg, 1993; 148(10)∶ 370.
12.	Pommier B, Beslot F, Simon A, et al. Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system [J]. J Neurosci, 2002; 22(5)∶ 2005.
13.	Tirassa P, Costa N, Aloe L. CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus of pentylenetetrazole (PTZ)-treated adult rats [J]. Neuropharmacology, 2005; 48(5)∶ 732.
14.	Crespi F, Corsi M, Reggiani A, et al. Involvement of cholecystokinin within craving for cocaine: role of cholecystokinin receptor ligands [J]. Expert Opin Investig Drugs, 2000; 9(10)∶ 2249.
15.	Simasko SM, Wiens J, Karpiel A, et al. Cholecystokinin increases cytosolic calcium in a subpopulation of cultured vagal afferent neurons [J]. Am J Physiol Regul Integr Comp Physiol, 2002; 283(6)∶ R1303.
16.	Miyasaka K, Ichikawa M, Ohta M, et al. Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor [J]. J Nutr, 2002; 132(4)∶ 739.
17.	Tapia JA, García-Marin LJ, Jensen RT. Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells [J]. J Biol Chem, 2003; 278(37)∶ 35220.
18.	Tirassa P, Costa N. CCK-8 induces NGF and BDNF synthesis and modulates TrkA and TrkB expression in the rat hippocampus and septum: Effects on kindling development [J]. Neurochem Int, 2007; 50(1)∶ 130.
19.	Tirassa P, Manni L, Aloe L, et al. Cholecystokinin-8 and nerve growth factor: two endogenous molecules working for the upkeep and repair of the nervous system [J]. Curr Drug Targets CNS Neurol Disord, 2002; 1(5)∶ 495.
20.	Manni L, Lundeberg T, Fiorito S, et al. Nerve growth factor release by human synovial fibroblasts prior to and following exposure to tumor necrosis factor-alpha, interleukin-1 beta and cholecystokinin-8: the possible role of NGF in the inflammatory response [J]. Clin Exp Rheumatol, 2003; 21(5)∶ 617.
21.	Manni L, Aloe L, Tirassa P, et al. Cholecystokinin-8 promotes recovery of sympathectomy induced by 6-hydroxydopamine in adult mice [J]. Neuroreport, 2001; 12(8)∶ 1621.
22.	Harkany T, Dobszay MB, Cayetanot F, et al. Redistribution of CB1 cannabinoid receptors during evolution of cholinergic basal forebrain territories and their cortical projection areas: a comparison between the gray mouse lemur (Microcebus murinus, primates) and rat [J]. Neuroscience, 2005; 135(2)∶ 595.
23.	Gatewood JD, Morgan MD, Eaton M, et al. Motherhood mitigates aging-related decrements in learning and memory and positively affects brain aging in the rat [J]. Brain Res Bull, 2005; 66(2)∶ 91.
24.	Sun XJ, Lu QC, Cai Y. Effect of cholecystokinin on experimental neuronal aging [J]. World J Gastroenterol, 2005; 11(4)∶ 551.
25.	Mátyás F, Freund TF, Gulyás AI. Convergence of excitatory and inhibitory inputs onto CCK-containing basket cells in the CA1 area of the rat hippocampus [J]. Eur J Neurosci, 2004; 19(5)∶ 1243.
26.	McCleane G. Cholecystokinin antagonists a new way to improve the analgesia from old analgesics? [J]. Curr Pharm Des, 2004; 10(3)∶ 303.
27.	Veraksits A, Rünkorg K, Kurrikoff K, et al. Altered pain sensitivity and morphine-induced anti-nociception in mice lacking CCK2 receptors [J]. Psychopharmacology(Berl), 2003; 166(2)∶ 168.
28.	Loonam TM, Noailles PA, Yu J, et al. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum [J]. Life Sci, 2003; 73(6)∶ 727.
29.	Rehfeld JF, Lindberg I, Friis-Hansen L. Increased synthesis but decreased processing of neuronal proCCK in prohormone convertase 2 and 7B2 knockout animals [J]. J Neurochem, 2002; 83(6)∶ 1329.

1. 20　孙登群, 孟翔凌. 胆囊收缩素在糖尿病并发胆囊结石中的地位与作用 [J]. 中国普外基础与临床杂志, 2006; 13(4)∶ 406 21　Manni L, Lundeberg T, Tirassa P, et al. Cholecystokinin-8 enhances nerve growth factor synthesis and promotes recovery of capsaicin-induced sensory deficit [J]. Br J Pharmacol, 2000; 129(4)∶ 744.
2. 　Ghijsen WE, Leenders AG, Wiegant VM. Regulation of cholecystokinin release from central nerve terminals [J]. Peptides, 2001; 22 (8)∶ 1213.
3. 　Tanganelli S, Fuxe K, Antonelli T, et al. Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates [J]. Peptides, 2001; 22(8)∶ 1229.
4. 　Hkfelt T, Holmberg K, Shi TJ, et al. CCK-ergic mechanisms in sensory systems [J]. Scand J Clin Lab Invest Suppl, 2001; 234∶ 69.
5. 　Blevins JE, Stanley BG, Reidelberger RD. Brain regions where cholecystokinin suppresses feeding in rats [J]. Brain Res, 2000; 860 (1-2)∶ 1.
6. 　Migrenne S, Marsollier N, Cruciani-Guglielmacci C, et al. Importance of the gut-brain axis in the control of glucose homeostasis [J]. Curr Opin Pharmacol, 2006; 6(6)∶ 592.
7. 　Eser D, Schüle C, Baghai TC, et al. Neuroactive steroids in depression and anxiety disorders: clinical studies [J]. Neuroendocrinology, 2006; 84(4)∶ 244.
8. 　Graf R, Klauser S, Fukuoka SI, et al. The bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provides protection against premature activation of pancreatic juice[J]. Pancreatology, 2003; 3(3)∶ 195.
9. 　Van de Wiele C, Signore A, Dierckx RA. Peptide receptor imaging: advances in the diagnosis of pulmonary diseases [J]. Am J Respir Med, 2002; 1(3)∶ 177.
10. 　Eguiagaray JG, Egea J, Bravo-Cordero JJ, et al. Neurotransmitters, calcium signalling and neuronal communication [J]. Neurocirugia (Astur), 2004; 15(2)∶ 109.
11. 　Schiffmann S. Localization and role of cholecystokinin and its receptors in the functional organization of the basal ganglia [J]. Bull Mem Acad R Med Belg, 1993; 148(10)∶ 370.
12. 　Pommier B, Beslot F, Simon A, et al. Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system [J]. J Neurosci, 2002; 22(5)∶ 2005.
13. 　Tirassa P, Costa N, Aloe L. CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus of pentylenetetrazole (PTZ)-treated adult rats [J]. Neuropharmacology, 2005; 48(5)∶ 732.
14. 　Crespi F, Corsi M, Reggiani A, et al. Involvement of cholecystokinin within craving for cocaine: role of cholecystokinin receptor ligands [J]. Expert Opin Investig Drugs, 2000; 9(10)∶ 2249.
15. 　Simasko SM, Wiens J, Karpiel A, et al. Cholecystokinin increases cytosolic calcium in a subpopulation of cultured vagal afferent neurons [J]. Am J Physiol Regul Integr Comp Physiol, 2002; 283(6)∶ R1303.
16. 　Miyasaka K, Ichikawa M, Ohta M, et al. Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor [J]. J Nutr, 2002; 132(4)∶ 739.
17. 　Tapia JA, García-Marin LJ, Jensen RT. Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells [J]. J Biol Chem, 2003; 278(37)∶ 35220.
18. 　Tirassa P, Costa N. CCK-8 induces NGF and BDNF synthesis and modulates TrkA and TrkB expression in the rat hippocampus and septum: Effects on kindling development [J]. Neurochem Int, 2007; 50(1)∶ 130.
19. 　Tirassa P, Manni L, Aloe L, et al. Cholecystokinin-8 and nerve growth factor: two endogenous molecules working for the upkeep and repair of the nervous system [J]. Curr Drug Targets CNS Neurol Disord, 2002; 1(5)∶ 495.
20. 　Manni L, Lundeberg T, Fiorito S, et al. Nerve growth factor release by human synovial fibroblasts prior to and following exposure to tumor necrosis factor-alpha, interleukin-1 beta and cholecystokinin-8: the possible role of NGF in the inflammatory response [J]. Clin Exp Rheumatol, 2003; 21(5)∶ 617.
21. 　Manni L, Aloe L, Tirassa P, et al. Cholecystokinin-8 promotes recovery of sympathectomy induced by 6-hydroxydopamine in adult mice [J]. Neuroreport, 2001; 12(8)∶ 1621.
22. 　Harkany T, Dobszay MB, Cayetanot F, et al. Redistribution of CB1 cannabinoid receptors during evolution of cholinergic basal forebrain territories and their cortical projection areas: a comparison between the gray mouse lemur (Microcebus murinus, primates) and rat [J]. Neuroscience, 2005; 135(2)∶ 595.
23. 　Gatewood JD, Morgan MD, Eaton M, et al. Motherhood mitigates aging-related decrements in learning and memory and positively affects brain aging in the rat [J]. Brain Res Bull, 2005; 66(2)∶ 91.
24. 　Sun XJ, Lu QC, Cai Y. Effect of cholecystokinin on experimental neuronal aging [J]. World J Gastroenterol, 2005; 11(4)∶ 551.
25. 　Mátyás F, Freund TF, Gulyás AI. Convergence of excitatory and inhibitory inputs onto CCK-containing basket cells in the CA1 area of the rat hippocampus [J]. Eur J Neurosci, 2004; 19(5)∶ 1243.
26. 　McCleane G. Cholecystokinin antagonists a new way to improve the analgesia from old analgesics? [J]. Curr Pharm Des, 2004; 10(3)∶ 303.
27. 　Veraksits A, Rünkorg K, Kurrikoff K, et al. Altered pain sensitivity and morphine-induced anti-nociception in mice lacking CCK2 receptors [J]. Psychopharmacology(Berl), 2003; 166(2)∶ 168.
28. 　Loonam TM, Noailles PA, Yu J, et al. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum [J]. Life Sci, 2003; 73(6)∶ 727.
29. 　Rehfeld JF, Lindberg I, Friis-Hansen L. Increased synthesis but decreased processing of neuronal proCCK in prohormone convertase 2 and 7B2 knockout animals [J]. J Neurochem, 2002; 83(6)∶ 1329.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Cholecystokinine on Nervous System

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