Steroid Receptor Coactivator Family and Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

TANG Peng , JIANG Jun

Breast Disease Center of Southwest Hospital, The Third Military Medical University, Chongqing 400038, China;

Corresponding author：

Keywords：

Steroid receptor coactivator; Breast cancer; Steroid hormone; Steroid receptor

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Objective　 To investigate the effect of steroid receptor coactivator family in initiation, development, treatment and prognosis of breast cancer.
Methods 　The literatures in recent years which have related to the effect of steroid receptor coactivators in breast cancer are reviewed.
Results 　Steroid receptor coactivators are essential for several kinds of steroid hormones binding to steroid receptors, so they are important accessory factors that induce the initiation, development and recurrence of breast cancer, and predictive factors that estimate the prognosis of breast cancer.
Conclusion 　Inhibition of the expression and signaling pathway of steroid receptor coactivators may be effective for breast cancer prevention and treatment.

Citation： TANG Peng,JIANG Jun. Steroid Receptor Coactivator Family and Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(3): 265-268. doi: Copy

1.	McKenna NJ, O’Malley BW. Combinatorial control of gene expression by nuclear receptors and coregulators [J]. Cell, 2002; 108(4)∶465.
2.	Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: the second decade [J]. Cell, 1995; 83(6)∶835.
3.	Onate SA, Tsai SY, Tsai MJ, et al. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily [J]. Science, 1995; 270(5240)∶1354.
4.	Takeshita A, Yen PM, Misiti S, et al. Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator [J]. Endocrinology, 1996; 137(8)∶3594.
5.	Kamei Y, Xu L, Heinzel T, et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors [J]. Cell, 1996; 85(3)∶403.
6.	Hong H, Kohli K, Trivedi A, et al. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors [J]. Proc Natl Acad Sci USA, 1996; 93(10)∶4948.
7.	Anzick SL, Kononen J, Walker RL, et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer [J]. Science, 1997; 277(5328)∶965.
8.	Shiau AK, Barstad D, Loria PM, et al. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen [J]. Cell, 1998; 95(7)∶927.
9.	Li J, O’Malley BW, Wong J. p300 requires its histone acetyltransferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin [J]. Mol Cell Biol, 2000; 20(6)∶2031.
10.	Koh SS, Chen D, Lee YH, et al. Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities [J]. J Biol Chem, 2001; 276(2)∶1089.
11.	Carapeti M, Aguiar RC, Chase A, et al. Assignment of the st-eroid receptor coactivator-1 (SRC-1) gene to human chromosome band 2p23 [J]. Genomics, 1998; 52(2)∶242.
12.	Ning G, Jurecic V, Baldini A, et al. Structure and chromosomal locations of mouse steroid receptor coactivator gene family [J]. In Vitro Cell Dev Biol Anim, 1999; 35(8)∶481.
13.	Puustinen R, Sarvilinna N, Manninen T, et al. Localization of glucocorticoid receptor interacting protein 1 in murine tissues using two novel polyclonal antibodies [J]. Eur J Endocrinol, 2001; 145(3)∶323.
14.	Xu J, Liao L, Ning G, et al. The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development [J]. Proc Natl Acad Sci USA, 2000; 97(12)∶6379.
15.	Xu J, Qiu Y, DeMayo FJ, et al. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene [J]. Science, 1998; 279(5358)∶1922.
16.	Picard F, Gehin M, Annicotte J, et al. SRC-1 and TIF2 control energy balance between white and brown adipose tissues [J]. Cell, 2002; 111(7)∶931.
17.	Gehin M, Mark M, Dennefeld C, et al. The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP [J]. Mol Cell Biol, 2002; 22(16)∶5923.
18.	Bouras T, Southey MC, Venter DJ. Overexpression of the st-eroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu [J]. Cancer Res, 2001; 61(3)∶903.
19.	List HJ, Reiter R, Singh B, et al. Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue [J]. Breast Cancer Res Treat, 2001; 68(1)∶21.
20.	Osborne CK, Bardou V, Hopp TA, et al. Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer [J]. J Natl Cancer Inst, 2003; 95(5)∶353.
21.	Mc Ilroy M, Fleming FJ, Buggy Y, et al. Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence [J]. Endocr Relat Cancer, 2006; 13(4)∶1135.
22.	Shou J, Massarweh S, Osborne CK, et al. Mechanisms of ta-moxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer [J]. J Natl Cancer Inst, 2004; 96(12)∶926.
23.	Louie MC, Zou JX, Rabinovich A, et al. ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance [J]. Mol Cell Biol, 2004; 24(12)∶5157.
24.	Tilli MT, Reiter R, Oh AS, et al. Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice [J]. Mol Endocrinol, 2005; 19(3)∶644.
25.	Planas-Silva MD, Shang Y, Donaher JL, et al. AIB1 enhances estrogen-dependent induction of cyclin D1 expression [J]. Cancer Res, 2001; 61(10)∶3858.
26.	Yan J, Yu CT, Ozen M, et al. Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway [J]. Cancer Res, 2006; 66(22)∶11039.
27.	Kuang SQ, Liao L, Zhang H, et al. AIB1/SRC-3 deficiency affects insulin-like growth factor Ⅰ signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice [J]. Cancer Res, 2004; 64(5)∶1875.
28.	Liao L, Kuang SQ, Yuan Y, et al. Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1 [J]. J Steroid Biochem Mol Biol, 2002; 83(1-5)∶3.
29.	List HJ, Lauritsen KJ, Reiter R,et al. Ribozyme targeting demonstrates that the nuclear receptor coactivator AIB1 is a rate-limiting factor for estrogen-dependent growth of human MCF-7 breast cancer cells [J]. J Biol Chem, 2001; 276(26)∶23763.
30.	Mussi P, Yu C, O’Malley BW, et al. Stimulation of steroid receptor coactivator-3 (SRC-3) gene overexpression by a positive regulatory loop of E2F1 and SRC-3 [J]. Mol Endocrinol, 2006; 20(12)∶3105.
31.	Myers E, Fleming FJ, Crotty TB, et al. Inverse relationship between ER-beta and SRC-1 predicts outcome in endocrine-resistant breast cancer [J]. Br J Cancer, 2004; 91(9)∶1687.
32.	Fleming FJ, Myers E, Kelly G, et al. Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1 [J]. J Clin Pathol, 2004; 57(10)∶1069.
33.	Newman SP, Bates NP, Vernimmen D, et al. Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer [J]. Oncogene, 2000; 19(4)∶490.
34.	Eddie M, Arnold H, Enda MD, et al. Recurrence in HER2 over-expressing breast cancer-a predictive role for PEA3 and SRC-1 [J]. J American College of Surgeons, 2004; 199(3)∶89.
35.	Kishimoto H, Wang Z, Bhat-Nakshatri P, et al. The p160 fa-mily coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12 [J]. Carcinogenesis, 2005; 26(10)∶1706.
36.	康骅, Robert E Mansel, Wen G Jiang. 基质细胞衍化因子-1的表达及其与乳腺癌患者预后的关系 [J]. 中国普外基础与临床杂志, 2005; 12(5)∶483.
37.	Lee SK, Kim HJ, Kim JW, et al. Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53 [J]. Mol Endocrinol, 1999; 13(11)∶1924.
38.	Cascio S, Bartella V, Garofalo C, et al. Insulin-like growth factor 1 differentially regulates estrogen receptor-dependent transcription at estrogen response element and AP-1 sites in breast cancer cells [J]. J Biol Chem, 2007; 282(6)∶3498.

1. McKenna NJ, O’Malley BW. Combinatorial control of gene expression by nuclear receptors and coregulators [J]. Cell, 2002; 108(4)∶465.
2. Mangelsdorf DJ, Thummel C, Beato M, et al. The nuclear receptor superfamily: the second decade [J]. Cell, 1995; 83(6)∶835.
3. Onate SA, Tsai SY, Tsai MJ, et al. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily [J]. Science, 1995; 270(5240)∶1354.
4. Takeshita A, Yen PM, Misiti S, et al. Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator [J]. Endocrinology, 1996; 137(8)∶3594.
5. Kamei Y, Xu L, Heinzel T, et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors [J]. Cell, 1996; 85(3)∶403.
6. Hong H, Kohli K, Trivedi A, et al. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors [J]. Proc Natl Acad Sci USA, 1996; 93(10)∶4948.
7. Anzick SL, Kononen J, Walker RL, et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer [J]. Science, 1997; 277(5328)∶965.
8. Shiau AK, Barstad D, Loria PM, et al. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen [J]. Cell, 1998; 95(7)∶927.
9. Li J, O’Malley BW, Wong J. p300 requires its histone acetyltransferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin [J]. Mol Cell Biol, 2000; 20(6)∶2031.
10. Koh SS, Chen D, Lee YH, et al. Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities [J]. J Biol Chem, 2001; 276(2)∶1089.
11. Carapeti M, Aguiar RC, Chase A, et al. Assignment of the st-eroid receptor coactivator-1 (SRC-1) gene to human chromosome band 2p23 [J]. Genomics, 1998; 52(2)∶242.
12. Ning G, Jurecic V, Baldini A, et al. Structure and chromosomal locations of mouse steroid receptor coactivator gene family [J]. In Vitro Cell Dev Biol Anim, 1999; 35(8)∶481.
13. Puustinen R, Sarvilinna N, Manninen T, et al. Localization of glucocorticoid receptor interacting protein 1 in murine tissues using two novel polyclonal antibodies [J]. Eur J Endocrinol, 2001; 145(3)∶323.
14. Xu J, Liao L, Ning G, et al. The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development [J]. Proc Natl Acad Sci USA, 2000; 97(12)∶6379.
15. Xu J, Qiu Y, DeMayo FJ, et al. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene [J]. Science, 1998; 279(5358)∶1922.
16. Picard F, Gehin M, Annicotte J, et al. SRC-1 and TIF2 control energy balance between white and brown adipose tissues [J]. Cell, 2002; 111(7)∶931.
17. Gehin M, Mark M, Dennefeld C, et al. The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP [J]. Mol Cell Biol, 2002; 22(16)∶5923.
18. Bouras T, Southey MC, Venter DJ. Overexpression of the st-eroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu [J]. Cancer Res, 2001; 61(3)∶903.
19. List HJ, Reiter R, Singh B, et al. Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue [J]. Breast Cancer Res Treat, 2001; 68(1)∶21.
20. Osborne CK, Bardou V, Hopp TA, et al. Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer [J]. J Natl Cancer Inst, 2003; 95(5)∶353.
21. Mc Ilroy M, Fleming FJ, Buggy Y, et al. Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence [J]. Endocr Relat Cancer, 2006; 13(4)∶1135.
22. Shou J, Massarweh S, Osborne CK, et al. Mechanisms of ta-moxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer [J]. J Natl Cancer Inst, 2004; 96(12)∶926.
23. Louie MC, Zou JX, Rabinovich A, et al. ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance [J]. Mol Cell Biol, 2004; 24(12)∶5157.
24. Tilli MT, Reiter R, Oh AS, et al. Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice [J]. Mol Endocrinol, 2005; 19(3)∶644.
25. Planas-Silva MD, Shang Y, Donaher JL, et al. AIB1 enhances estrogen-dependent induction of cyclin D1 expression [J]. Cancer Res, 2001; 61(10)∶3858.
26. Yan J, Yu CT, Ozen M, et al. Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway [J]. Cancer Res, 2006; 66(22)∶11039.
27. Kuang SQ, Liao L, Zhang H, et al. AIB1/SRC-3 deficiency affects insulin-like growth factor Ⅰ signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice [J]. Cancer Res, 2004; 64(5)∶1875.
28. Liao L, Kuang SQ, Yuan Y, et al. Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1 [J]. J Steroid Biochem Mol Biol, 2002; 83(1-5)∶3.
29. List HJ, Lauritsen KJ, Reiter R,et al. Ribozyme targeting demonstrates that the nuclear receptor coactivator AIB1 is a rate-limiting factor for estrogen-dependent growth of human MCF-7 breast cancer cells [J]. J Biol Chem, 2001; 276(26)∶23763.
30. Mussi P, Yu C, O’Malley BW, et al. Stimulation of steroid receptor coactivator-3 (SRC-3) gene overexpression by a positive regulatory loop of E2F1 and SRC-3 [J]. Mol Endocrinol, 2006; 20(12)∶3105.
31. Myers E, Fleming FJ, Crotty TB, et al. Inverse relationship between ER-beta and SRC-1 predicts outcome in endocrine-resistant breast cancer [J]. Br J Cancer, 2004; 91(9)∶1687.
32. Fleming FJ, Myers E, Kelly G, et al. Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1 [J]. J Clin Pathol, 2004; 57(10)∶1069.
33. Newman SP, Bates NP, Vernimmen D, et al. Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer [J]. Oncogene, 2000; 19(4)∶490.
34. Eddie M, Arnold H, Enda MD, et al. Recurrence in HER2 over-expressing breast cancer-a predictive role for PEA3 and SRC-1 [J]. J American College of Surgeons, 2004; 199(3)∶89.
35. Kishimoto H, Wang Z, Bhat-Nakshatri P, et al. The p160 fa-mily coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12 [J]. Carcinogenesis, 2005; 26(10)∶1706.
36. 康骅, Robert E Mansel, Wen G Jiang. 基质细胞衍化因子-1的表达及其与乳腺癌患者预后的关系 [J]. 中国普外基础与临床杂志, 2005; 12(5)∶483.
37. Lee SK, Kim HJ, Kim JW, et al. Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53 [J]. Mol Endocrinol, 1999; 13(11)∶1924.
38. Cascio S, Bartella V, Garofalo C, et al. Insulin-like growth factor 1 differentially regulates estrogen receptor-dependent transcription at estrogen response element and AP-1 sites in breast cancer cells [J]. J Biol Chem, 2007; 282(6)∶3498.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Steroid Receptor Coactivator Family and Breast Cancer

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