Suppressing Function of Breast Cancer Metastasis Suppressor 1 in Breast Cancer Metastasis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

XIE Jing , JIANG Jun

Breast Disease Center of Southwest Hospital, The Third Military Medical University， Chongqing 400038, China;

Corresponding author：

Keywords：

Breast cancer metastasis suppressor 1; Breast cancer; Metastasis

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Objective 　To review the recent studies on the suppressing function of breast cancer metastasis suppressor 1 (BRMS1) in breast cancer metastasis.
Methods 　The recent literatures on the mechanisms of BRMS1 in the breast cancer that were published in and abroad were reviewed and summarized.
Results 　BRMS1, similar to the other anti-metastasis genes, only suppresses the metastasis of breast cancer cells but has nothing to do with the growth of tumor. BRMS1 could suppress metastasis of tumor cells by reestablishing both the homospecific and the heterospecific gap junctional intercellular comminications (GJIC) and by altering the expressions of relevant metastasis genes in the breast cancer.
Conclusion 　Further studies on BRMS1 may be helpful to understand the metastasis of breast cancer, which may provide a new way for the diagnosis and treatment of breast cancer.

Citation： XIE Jing,JIANG Jun. Suppressing Function of Breast Cancer Metastasis Suppressor 1 in Breast Cancer Metastasis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(3): 269-272. doi: Copy

1.	Seraj MJ, Samant RS, Verderame MF, et al. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13 [J]. Cancer Res， 2000; 60(11)∶2764.
2.	Samant RS, Debies MT, Shevde LA, et al. Identification and characterization ofthe murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1) [J]. Int J Cancer， 2002; 97(1)∶15.
3.	Shevde LA, Samant RS, Goldberg SF, et al. Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1 [J]. Exp Cell Res， 2002; 273(2)∶229.
4.	Seraj MJ, Harding MA, Gildea JJ, et al. The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines [J]. Clin Exp Metastasis， 2000; 18(6)∶519.
5.	Kauffman EC, Robinson VL, Stadler WM, et al. Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site [J]. J Urol， 2003; 169(3)∶1122.
6.	张殊，林其德，狄文. BRMS1和fascin基因在卵巢上皮癌中的表达及其意义 [J]. 现代妇产科进展， 2003； 12(3)∶167.
7.	Samant RS, Seraj MJ, Saunders MM, et al. Analysis of mechanisms underlying BRMS1 suppression of metastasis [J]. Clin Exp Metastasis， 2000; 18(8)∶683.
8.	Saunders MM, Seraj MJ, Li Z, et al. Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication [J]. Cancer Res， 2001; 61(5)∶1765.
9.	Meehan WJ, Samant RS, Hopper JE, et al. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription [J]. J Biol Chem， 2004; 279(2)∶1562.
10.	Meehan WJ, Welch DR. Breast cancer metastasis suppressor 1: update [J]. Clin Exp Metastasis， 2003; 20(1)∶45.
11.	Samant RS, Debies MT, Hurst DR, et al. Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1) [J]. Cancer Lett， 2006; 235(2)∶260.
12.	DeWald DB, Torabinejad J, Samant RS, et al. Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells [J]. Cancer Res， 2005; 65(3)∶713.
13.	Cicek M, Samant RS, Kinter M, et al. Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells [J]. Clin Exp Metastasis， 2004; 21(2)∶149.
14.	Ahn SH, Sawada H, Ro JY, et al. Differential expression of annexin Ⅰ in human mammary ductal epithelial cells in normal and benign and malignant breast tissues [J]. Clin Exp Metastasis， 1997; 15(2)∶151.
15.	Wulfkuhle JD, Sgroi DC, Krutzsch H, et al. Proteomics of human breast ductal carcinoma in situ [J]. Cancer Res， 2002; 62(22)∶6740.
16.	Yokota S, Yamamoto Y, Shimizu K, et al. Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma [J]. Cell Stress Chaperones， 2001; 6(4)∶345.
17.	Cicek M, Fukuyama R, Welch DR, et al. Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity [J]. Cancer Res， 2005; 65(9)∶3586.
18.	Baek SH, Ohqi KA, Rose DW, et al. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappa B and beta-amyloid precursor protien [J]. Cell, 2002; 110(10)∶55.
19.	Kleer CG, Griffith KA, Sabel MS, et al.RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast [J]. Breast Cancer Res Treat， 2005; 93(2)∶101.
20.	Stark AM, Tongers K, Maass N, et al. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases [J]. J Cancer Res Clin Oncol， 2005; 131(3)∶191.
21.	唐鲁兵，高海东，刘焕涛，等. BRMS1 mRNA在乳腺癌中的表达与腋淋巴结转移的关系 [J]. 山东大学学报（医学版）， 2005； 43(12)∶1163.
22.	Kelly LM, Buggy Y, Hill A, et al. Expression of the breast cancer metastasis suppressor gene, BRMS1, in human breast carcinoma: lack of correlation with metastasis to axillary lymph nodes [J]. Tumour Biol， 2005; 26(4)∶213.

1. Seraj MJ, Samant RS, Verderame MF, et al. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13 [J]. Cancer Res， 2000; 60(11)∶2764.
2. Samant RS, Debies MT, Shevde LA, et al. Identification and characterization ofthe murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1) [J]. Int J Cancer， 2002; 97(1)∶15.
3. Shevde LA, Samant RS, Goldberg SF, et al. Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1 [J]. Exp Cell Res， 2002; 273(2)∶229.
4. Seraj MJ, Harding MA, Gildea JJ, et al. The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines [J]. Clin Exp Metastasis， 2000; 18(6)∶519.
5. Kauffman EC, Robinson VL, Stadler WM, et al. Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site [J]. J Urol， 2003; 169(3)∶1122.
6. 张殊，林其德，狄文. BRMS1和fascin基因在卵巢上皮癌中的表达及其意义 [J]. 现代妇产科进展， 2003； 12(3)∶167.
7. Samant RS, Seraj MJ, Saunders MM, et al. Analysis of mechanisms underlying BRMS1 suppression of metastasis [J]. Clin Exp Metastasis， 2000; 18(8)∶683.
8. Saunders MM, Seraj MJ, Li Z, et al. Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication [J]. Cancer Res， 2001; 61(5)∶1765.
9. Meehan WJ, Samant RS, Hopper JE, et al. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription [J]. J Biol Chem， 2004; 279(2)∶1562.
10. Meehan WJ, Welch DR. Breast cancer metastasis suppressor 1: update [J]. Clin Exp Metastasis， 2003; 20(1)∶45.
11. Samant RS, Debies MT, Hurst DR, et al. Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1) [J]. Cancer Lett， 2006; 235(2)∶260.
12. DeWald DB, Torabinejad J, Samant RS, et al. Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells [J]. Cancer Res， 2005; 65(3)∶713.
13. Cicek M, Samant RS, Kinter M, et al. Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells [J]. Clin Exp Metastasis， 2004; 21(2)∶149.
14. Ahn SH, Sawada H, Ro JY, et al. Differential expression of annexin Ⅰ in human mammary ductal epithelial cells in normal and benign and malignant breast tissues [J]. Clin Exp Metastasis， 1997; 15(2)∶151.
15. Wulfkuhle JD, Sgroi DC, Krutzsch H, et al. Proteomics of human breast ductal carcinoma in situ [J]. Cancer Res， 2002; 62(22)∶6740.
16. Yokota S, Yamamoto Y, Shimizu K, et al. Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma [J]. Cell Stress Chaperones， 2001; 6(4)∶345.
17. Cicek M, Fukuyama R, Welch DR, et al. Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity [J]. Cancer Res， 2005; 65(9)∶3586.
18. Baek SH, Ohqi KA, Rose DW, et al. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappa B and beta-amyloid precursor protien [J]. Cell, 2002; 110(10)∶55.
19. Kleer CG, Griffith KA, Sabel MS, et al.RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast [J]. Breast Cancer Res Treat， 2005; 93(2)∶101.
20. Stark AM, Tongers K, Maass N, et al. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases [J]. J Cancer Res Clin Oncol， 2005; 131(3)∶191.
21. 唐鲁兵，高海东，刘焕涛，等. BRMS1 mRNA在乳腺癌中的表达与腋淋巴结转移的关系 [J]. 山东大学学报（医学版）， 2005； 43(12)∶1163.
22. Kelly LM, Buggy Y, Hill A, et al. Expression of the breast cancer metastasis suppressor gene, BRMS1, in human breast carcinoma: lack of correlation with metastasis to axillary lymph nodes [J]. Tumour Biol， 2005; 26(4)∶213.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Suppressing Function of Breast Cancer Metastasis Suppressor 1 in Breast Cancer Metastasis

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